Induction of the labor with Misoprostol vs. Oxytocin

Authors

  • Orlando Borré Arrieta
  • Benjamín Rodríguez Yances
  • César Mendivil Ciodaro
  • William Angarita Peñaranda
  • José Borré Aguilera

DOI:

https://doi.org/10.18597/rcog.707

Keywords:

Misoprostol, Oxytocin, induction of labor

Abstract

INTRODUCTION: The induction of the labor consists in the artificial initiation of the uterine activity. At the present time, three principal methods of induction exist: the Oxytocin, prostaglandins, and the amniotomy.

OBJECTIVE: The purpose of the present prospective and randomized study is to compare the efficacy and security of upward dose of Misoprostol, with an infusion of Oxytocin, for the induction of the labor.

MATERIAL AND METHODS: The patients in this study with any indication for induction of labor, to the Rafael Calvo Maternity Clinic, in Cartagena-Colombia, from September 8, 1998 to February 4, 1999.

From 136 patient, only 100 completed the selection criteria; 50 patient were treated with Misoprostol and 50 with Oxytocin.

RESULTS: There wasn’t statistical difference in the complications with the use of both drugs, but we observed less time with Misoprostol than with Oxytocin for induction of the labor, which was statistically significant, in spite of greater number of patients with an index of Bishop <3.

CONCLUSION: The Misoprostol is an effective and sure drug in the induction of labor.

Author Biographies

Orlando Borré Arrieta

Profesor Asociado

Benjamín Rodríguez Yances

Profesor Asistente

César Mendivil Ciodaro

Profesor Asistente

William Angarita Peñaranda

Residente III

References

Magann EF, Perry KG, Dockry JR, Bass JD, Chauhan SP, Morrison IC. Cervical ripening before medical induction of labor: a comparison of prostaglandin E2 estradiol, and oxytocin. Am J Obstet Gynecol 1995; 172 1702-8.

Theobal D, GW Graham A, Campbell J, Gange PO. Driscoll WD the use of postpituitary extract in physiological amounts in obstetrics. A preliminary report. BMJ 1948; 2: 123-7.

Du Vigneaud V, Ressler C, Swan JM, et al. The synthesis of an octapeptide amide with the hormonal activity of oxytocin. J Am Chem Soc 1953; 75: 4879-80.

Ralph L Kramer, George L Gilson, David S Morrison, Dibe Martin, et al. A randomized trial of Misoprostol and Oxytocin for induction of labor. Safety and efficacy. Obstet and Ginecol 1997; 2: 3.

Sánchez-Ramos L, Kaunitz A, Wears R, Delke Isaac, Gaudier F. Misoprostol for cervical ripening and labor induction. A metaanalysis. Obstet Gynecol 1997; 89: 633-642.

Wing DA, et al. A comparison of misoprostol and prostaglandin E2 gel for preinduction cervical ripening and labor induction. Am J Obstet Gynecol 1995; 172: 1804-1810.

Jaye M. Petrie R. Oxytocin for the induction or augmentation of labor. Clin Obstet Gynecol 1995; 2: 225-236.

American College of Obstetricians and Gynecologists. Induction and augmentation of labor. ACOG Technical bulletin No. 157 Washington, DC: American College of Obstetricians and Gynecologists 1991.

Bishop EH. Pelvic scoring for elective induction. Obstet Gynecol 1964; 24: 266-268.

Gordon-Wright AP, Elder MG. Prostaglandin E2 tablets used intravaginally for the induction of labor. Br J Obstet Gynecol 1979; 96: 32-36.

Sánchez-Ramos L, Kaunitz Am, Del Valle GO, Delke, Scrhoeder PA, Briones DK. Labor induction with the prostaglandin El Methyl Analogue Misoprostol Vs. Oxitocin: A randomized trail. Obstet Gynecol 1993; 81: 332-6.

Wing DA, Rahall A, Jones MM, Goodwin TM, Paul RH. Misoprostol an effective agent for cervical ripening and labor induction. Am J Obstet Gynecol 1995; 172: 1811-6.

Prins RP, Bolton RN, Mark C, et al. Cervical ripening with intravaginal prostaglandin E2 gel. Obstet Gynecol 1983; 61: 459- 462.

How to Cite

1.
Borré Arrieta O, Rodríguez Yances B, Mendivil Ciodaro C, Angarita Peñaranda W, Borré Aguilera J. Induction of the labor with Misoprostol vs. Oxytocin. Rev. colomb. obstet. ginecol. [Internet]. 2000 Mar. 30 [cited 2024 May 12];51(1):8-11. Available from: https://revista.fecolsog.org/index.php/rcog/article/view/707

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Published

2000-03-30
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