Estudio de la eficacia de misoprostol comparado con oxitocina, en la inducción del parto en la amenorrea prolongada
DOI:
https://doi.org/10.18597/rcog.779Keywords:
Efficacy, misoprostol, oxitocyn, induction of labor, RCTAbstract
A randomized clinical trial was done, in order to compare the effectiviness and safety of misoprostol. Intravaginal doses of 50 micrograms (mcg) were applied to the patients randomly allocatcd to experimental groups. Control patients recelved conventional doses of oxytocin, administered by continuous intravcnous infusion. The primary output measure was the time interval between the begining of the induction procedure and the expulsion of the fetus (11 - P). Secondary output measures are described in the full paper.
The 89 patiens studied were distributed as follows: 47 received misoprostol and 42 received oxytocin. Four patients allocated to the misoprostol group were excluded: one received oxytocin plus misoprostol by dccision ofthe attcnding obstetrician and three abandoned the trial for personal decision. The II-P time interval was 15.38 ± 1.53 hours for misoprostol and 18.56 ± 1.95 hours for oxytocin. Neither the differences between the two gr·oups rcgarding thc pdmary outcome meassure, nor thc diffcr·cnces in any of all the secÍÍndary output measures, were statistically significant. Accordingly, thc use ofmisoprostol is rccommcndcd for· induction of labor in cases ofprolonged amenorrhea, considering that it is less expensive, easier to apply and safe.
Author Biographies
Jorge Mosquera
Profesor hora cátedra. Depto. de Obstetricia y Ginecología. Escuela de Medicina, Universidad del Valle.
Julio César Mora
Hernando Navarro
Edgar Cobo
Profesor Emérito de Obstetricia y Ginecología, Escuda de Medicina. Universidad del Valle. Jefe del Depto. de Obstetricia y Ginecología. Fundación Clínica Valle del Lili.
César Neíra
Instructor de Ecografía. Depto. de Obstetricia y Ginecología.
Escuela de Medicina, Universidad del Valle.
Jhonny Zúñiga
References
Arias F. Preclictability of complications associated with prolonged pregnancy. Obstet Ginecol 1987; 70: 101-105.
Clifford HS. Postmaturity with placental dysfunction. Clinical syndrome and pathologic fíndings. J Pediat 1954; 1: 44-49.
Harris BA .. Huddeston JF. , Sutiiff G., Pedis HW.The unfavorable cervix in prolonged pregnancy. Obstet Gynecol. 1983: 62: 171-173.
Garris RE., Kirwood CF. Misoprostol: A prostaglandin E-1 analogue. Clin Pharmacokinet 1989: 98: 627- 644.
Soutag SJ., Mazure PA .. Poutes JF et al. Misoprostol in the treatment of duodenal peptic ulcer. A multicenter double-blind placebocontrolled study. Dig Dis Sci 1985; 30: 159s -163s.
Bugalho A., Bique C.. Almeida L., Bergstrom S. Aplication of vaginal misoprostol befare cervical dilatation to facilite first-trimester pregnancy interruption. Obstet Gynecol 1994; 83: 729-731.
Norman JE .. Thong KJ .. Baird DT. Uterine contraction and induction of abortion in early pregnancy by misoprostol and mifepristone. Lancet 1991 ; 338: 1233-1236.
Schaff EA .. Worthman M .. Eisinger S., Franks P. Methotrexate and misoprostol when surgical abortion fail. Obstetric Gynecol 1996-87- 450-452.
Sánchez L., Kaunitz A., Del Valle G ., Delke I., Schroder P., Briones D. Labor induction with the prostaglandin E - 1 Methyl analogue misoprostol versus oxytocin: Arandomized trial. Obstet Ginecol 1993; 81: 332-336.
Campos GA., Margulies M., Voto LS .. Rodriguez A .. Guzman S. Misoprostol un análogo de Pg E- 1 para la inducción de parto a término-. Estudio comparativo y ramdomizado con oxitocina. Obst Ginec Lat Americ 1994; 52: 158-165.
Buser D., Mora G .. Arias F. A Randomized comparition between misoprostol an dinoprostone for cervical ripening and labor induction in patien with unfavorable cervices. Obstet Gynecol 1987; 89: 581-585.
Wing D., Jones M .. Rebail A.. Godwin M .. Paul R. A comparison of misoprostol and prostaglandin E-2 gel for preinduction cervical ripening and labor induction. Am J Obstet Gynecol 1995; 1: 804-810.
Wingal S .. Kee W .. Lao T .. Chung ho P. Cervical priming oral misoprostol in prelabor rupture of membranas at term. Obstet Gynecol 1996; 87: 927-936.
Norman M., Ekman G., Malmstrom A. Prostaglandin E2-induced opening of the human cervix involves changes in proteoglycan metabolism. Obstet Gynecol 1993; 82: 1013-1020.
Gottschal D.. Borgida A .. Mijalek J., Sauer F. A randomized clinical trial comparing misoprostol with prostaglandin E2 gel for preinduction cervical ripening. Am J Obstet Gynecol 1997; 1177: 1067-1070.
Kramer RL. A randomized trial of misoprostol and oxytocin for induction of labor: safety and efficacy . Obstet Gynecol 1977 ;89:387-391.
Feingold M. A randomized trial of misoprostol an oxytocin for induction of labor: safety and eficac (Letter) . Obstet Gynecol. 1997 Jul.
Kandanalí S., Kucukoskan T., Zor N et al. Comparison of labor induction with misoprostol vs. oxytocin prostaglandin E-2 in term pregnancy. Int J Gynaecol Obst 1996; -55(2): 99-104.
Bugalho A .. Bique C., Machungo F., Faúndes A. Vaginal misoprostol as an alternative to oxytocin for induction of labor in women with late fetal death. Am J Obstet Gynecol 1994; 171 : 538-541.
Echavarría E .. Rocha M. Estudio comparativo randomizado de inducción de parto con oxitocina y mi soprostol en embarazos en vías de prolongación . Rev Chil Obstet Ginecol 1995; 60: 108- 111 .
Escudero F., Contreras H. A comparative trial of induction with misoprostol versus oxytocin. Int J Gynaecol Obstet 1997: 57: 139-143.
Kierse MJNC. Prostaglandins in preinduction cervical ripening: meta-analysis of worldwide clinical experience. J Reprod Med 1993; 38: 89-100.
Farah L., Ramos L ., Rosa C., Delvalle G., Gaudier F., Deike L. , Kaunitz A. Randomized trial of two doses of the prostaglandin E-1 analogue misoprostol for labor induction. Am J Obstet Gynecol 1997; 177: 3(J4-371.
American College of Obstetrics and Gynecology. Induction of labor. Washington: 1995. AGOG Technical Bulletin No. 217.
Windrim R. , Benett K., Mundie W et al. Oral administration of misoprostol for labor induction: a randomized controlled trial. Obstet Gynecol 1997; R9: 392-397.
Friedman EA., Sachtienben MR. Dysfuntional labor Prolonged latent phase in the nullipara. Obstet Gynecol 1961; 17: 135-140.
Altman DG. Practical stadistics for medical research. Chapman B.hall, London 1992; 455-458.
How to Cite
Downloads
Downloads
Published
Issue
Section
License
Copyright (c) 2016 Revista Colombiana de Obstetricia y Ginecología
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
