Association between anticardiolipins and anti B2 glycoprotein 1 and preclampsia before 35 gestational weeks
DOI:
https://doi.org/10.18597/rcog.745Keywords:
Preeclampsia, Anticardiolipin, b2 Glycoprotein I, AntiphospholipidsAbstract
Objective: To explore association between Inmunoglobulins G Anticardiolipina and Anti b2 Glycoprotein I with Preeclampsia and related complications before 35 weeks of pregnancy.
Methodology: Case control prospective descriptive study with 55 preeclamptics and 55 non preeclamptics pregnant patients before 35 weeks of gestational age at The Hospital Universitario San Vicente de Paúl and Hospital General de Medellín, between September 1° -1999 and September 1° -2000.
Results: Over a one year period we studied 55 preeclamptic patients (90,9% severe) for ACA and Ab2GP I and its relation with attributable complications; comparison was made with 54 non-preeclamptic pregnant patients. There were no significative differences in the general characteristics of the patients.1/55 case has Ab2GP I vs. 5/54 control (P=0.09 ns ). 7/55 cases had positive titles for AC vs. 11/54 controls (P=0.47 ns ). (Interpretation by house factoring recommendation). 24/55 cases resulted positives for AC vs. 30/54 controls (P=0,48 ns) Interpretation by international guide) (AC1). 25/55 cases of Fetal Growth Restriction were not associated to the antibodies AC,AC1 nor Ab2GP I. From fourteen cases with severe complications (Hellp, abruptio, pulmonary edema, etc.) none were related to the studied antibodies.
None of the controls presented PE; one of positives was complicated by pulmonary embolism but related to mitral estenosis.
Conclusion: There is not an association between preeclampsia before 35 weeks and related complications and Ab2GP I or AC.
Author Biographies
Jorge Mario Gómez Jiménez
Héctor Iván García García
Jáder Gómez Gallego
Alejandro Quintero Galeano
Clara María Mesa Restrepo
Natalia Aguirre
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