El síndrome de ovarios poliquísticos y su rol potencial en la patogénesis de la hipertensión inducida por el embarazo

  • Leyla Margarita Kuzmar-Daza
  • Ivonne Díaz-Yamal
  • Luis Ernesto Pérez-Agudelo

Resumen

La hipertensión inducida por el embarazo-HIE (que incluye preeclampsia e hipertensión gestacional) es una complicación común del embarazo, cuya patogénesis se mantiene incierta.

Muchas manifestaciones del síndrome de ovarios poliquísticos (SOP) se han asociado con esta patología. Estas incluyen hipertensión, hiperinsulinemia, intolerancia a la glucosa, obesidad, y anormalidades lipídicas. Otras anormalidades presentes incluyen la elevación en los niveles de leptina, factor de necrosis tumoral (FNT), activador del plasminógeno tisular (APT), inhibidor del plaminógeno tisular-1 (IPT-1) y testosterona. El documentar estos hallazgos antes del inicio de la hipertensión en el embarazo sugiere que la resistencia a la insulina o sus anormalidades asociadas, pueden tener un papel importante en la patogénesis de este desorden. Más aún, el identificar que estas manifestaciones del síndrome de resistencia a la insulina pueden persistir muchos años después de la gestación, indica que estas mujeres tendrían mayor riesgo de desarrollar enfermedades cardiovasculares en el futuro. Estas observaciones sugieren que las intervenciones dirigidas a disminuir la resistencia a la insulina podrían reducir tanto el riesgo de desarrollar hipertensión en el embarazo, como complicaciones cardiovasculares años más tarde.

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Biografía del autor/a

Leyla Margarita Kuzmar-Daza
Residente III nivel Gineco-obstetricia. Universidad Surcolombiana, Neiva, Colombia.
Ivonne Díaz-Yamal
Especialista en Ginecología y Obstetricia. Profesor Asistente, Coordinadora Unidad de Infertilidad y Endocrinología Reproductiva. Sección de Obstetricia y Ginecología, Universidad Nueva Granada, Hospital Militar, Bogotá, Colombia.
Luis Ernesto Pérez-Agudelo
Especialista en Ginecología y Obstetricia. Profesor Titular Infertilidad y Endocrinología Reproductiva. Sección de Obstetricia y Ginecología, Universidad Nueva Granada, Hospital Militar, Bogotá, Colombia .

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Publicado
2007-12-20
Cómo citar
1.
Kuzmar-Daza LM, Díaz-Yamal I, Pérez-Agudelo LE. El síndrome de ovarios poliquísticos y su rol potencial en la patogénesis de la hipertensión inducida por el embarazo. Rev. Colomb. Obstet. Ginecol. [Internet]. 20 de diciembre de 2007 [citado 21 de septiembre de 2021];58(4):309-15. Disponible en: https://revista.fecolsog.org/index.php/rcog/article/view/442
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