Hypothyroidism and risk of miscarriage
DOI:
https://doi.org/10.18597/rcog.344Keywords:
pregnancy, hypothyroidism, subclinical hypothyroidism, miscarriage, autoimmunity, thyroid auto antibodies, thyroiditis, thyroxineAbstract
Objective: this article was aimed at searching the literature for an association between hypothyroidism and miscarriage.
Methodology: a search was made on the Medline electronic database, using Pubmed and Ovid for identifying relevant material.
Results: some studies showed an increased risk of miscarriage in patients suffering from overt hypothyroidism and subclinical hypothyroidism, and in euthyroid patients having antithyroid antibodies; a strong association was seen in the latter group. Early diagnosis and treatment of pregnant women having subclinical, overt hypothyroidism and the search for antithyroid antibodies is highly recommended in recurrent miscarriage. Despite some studies having shown a decrease in the risk of miscarriage when levothyroxine treatment was used with patients having antithyroid antibodies, it cannot be recommended yet.
Conclusion: more studies using an increased number of patients have to be carried out to define a true association between miscarriage and thyroid disorders and thus establish suitable treatment.
Author Biographies
Carlos Arturo Vivas
Jenny Soraya Cárdenas
Sandra Milena Cardozo
Katherine Carvajal-Canizales
Juan Camilo Cifuentes
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