Polycystic ovary syndrome and its potential role in the pathogenesis of pregnancy-induced hypertension
DOI:
https://doi.org/10.18597/rcog.442Keywords:
pregnancy-induced hypertension, preeclampsia, polycystic ovary syndrome, insulin resistanceAbstract
Pregnancy-induced hypertension which includes both gestational hypertension and preeclampsia is a common and morbid pregnancy complication for which the pathogenesis remains unclear.
Many features of polycystic ovary syndrome have been associated with this condition; these would include hypertension, hyper-insulinaemia, glucose intolerance, obesity and lipid abnormalities.
Other accompanying abnormalities may include increased leptin levels, tissue necrosis factor, tissue plasminogen activator, plasminogen activator inhibitor-1 and testosterone.
Documenting these alterations before the onset of hypertension in pregnancy suggests that insulin resistance or associated abnormalities may play a role in this disorder’s pathogenesis.
Furthermore, recognising that insulin resistance syndrome features persist many years after pregnancy, amongst women having this condition, raises the possibility that these women may have an increased risk of future cardiovascular disease.
These observations suggest that interventions to reduce insulin resistance may reduce the risk of hypertension in pregnancy and later-life cardiovascular complications.
Author Biographies
Leyla Margarita Kuzmar-Daza
Ivonne Díaz-Yamal
Luis Ernesto Pérez-Agudelo
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