Molecular aspects of human papillomavirus and cervical cancer
DOI:
https://doi.org/10.18597/rcog.395Keywords:
human papillomavirus, cervical cancer, cell cycle, pathogenesis, oncogenesis p53, pRb, E6, E7Abstract
Objective: reviewing the mechanisms involved in pathogenesis and oncogenesis associated with human papillomavirus in cervical epithelium.
Method: an electronic search was made for identifying relevant literature in Medline, in English or Spanish, from 2000 to 2007. All original cancer studies assessing the oncogenesis and pathogenesis of human papillomavirus in cervical epithelium were chosen; recognised medical books were also searched for information regarding this topic.
Results: human papillomavirus is the most prevalent infection affecting the sexually-active population and its relationship with cervical cancer is well known. Molecular biology and cancer's genetics are useful tools in understanding carcinogenesis.
Conclusions: only the deepest knowledge regarding human papillomavirus infection will provide better and early diagnosis methods at a time leading to the appearance of newer therapeutical targets in the fight against cancer.
Author Biographies
Carlos Fernando Grillo-Ardila
Mercy Yolima Martínez-Velásquez
Buenaventura Morales-López
References
Hacker NF. Cáncer cervical. En: Berek JS, Hacker NF, editores. Ginecología oncológica práctica. 4a. ed. México D.F.: McGraw Hill Interamericana; 2006. p. 337-95.
Aragón ME. Cáncer de cuello uterino. En: Texto de ginecología. 1a. edición. Bogotá: NET Educativa Editorial; 2007. p. 389-400.
Castro MA, Vera LM, Posso HJ. Epidemiología del cáncer de cuello uterino: estado del arte. Rev Colomb Obstet Ginecol 2006;57:182-9.
Lewin B. Cell cycle and growth regulation. En: Lewin B. Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall; 2004. p. 843-88.
Jo H, Kim JW. Implications of HPV infection in uterine cervical cancer. Cancer Ther 2005,3:419-34.
Clarke B, Chetty R. Cell cycle aberrations in the patogénesis of squamous cell carcinoma of the uterine cervix. Gynecol Oncol 2001;82:238-46.
Wolf JK, Franco EL, Arbeit JM, Shroyer KR, Wu T, Runowicz CD, et al. Innovations in understanding the biology of cervical cancer. Cancer 2003;98:2064-9.
Sanseverino F, Torricelli M, Petraglia F, Giordano A. Role of the retinoblastoma family in gynecological cancer. Cancer Biol Ther 2003;2:636-41.
Gasco M, Shami S, Crook T. The p53 pathway in breast cancer. Breast Cancer Res 2002;4:70-6.
Kim YT, Zhao M. Aberrant cell cycle regulation in cervical carcinoma. Yonsei Med J 2005;46:597-613.
Lewin B. Oncogenes and cancer. En: Lewin B. Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall; 2004. p. 889-937.
Elqui de Oliveira DE. DNA viruses in human cancer: an integrated overview on fundamental mechanisms of viral carcinogenesis. Cancer Lett 2007;247:182-96.
Janicek MF, Averette HE. Cervical cancer: prevention, diagnosis, and therapeutics. CA Cancer J Clin 2001;51:92-114.
de Villiers EM, Fauquet C, Broker TR, Bernard HU, zur Hausen TR. Classification of papillomaviruses. Virology 2004;324:17-27.
Boulet G, Hor vath C, Broeck DV, Sahebali S, Vanden Bogers J. Human papillomavirus: E6 and E7 oncogenes. Int J Biochem Cell Biol 2007;39:2006-11.
Stanley MA.Human papillomavirus and cervical carcinogenesis. Best Pract Res Clin Obstet Gynaecol 2001;15:663-76.
Longworth MS, Laimins LA. Pathogenesis of human papillomaviruses in differentiating epithelia. Microbiol Mol Biol Rev 2004;68:362-72.
Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T. The role of human papilloma virus in the molecular biology of cervical carcinogenesis. Kobe J Med Sci 2004;50:9-19.
Man S, Fiander A. Immunology of human papillomavirus infection in lower genital tract neoplasia. Best Pract Res Clin Obstet Gynaecol 2001;15:701-14.
Narisawa-Saito M, Kiyono T. Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins. Cancer Sci 2007;98:1505-11.
Yoshida T, Sano T, Kanuma T, Owada N, Sakurai S, Fukuda T, et al. Quantitative real-time polymerase chain reaction analysis of the type distribution, viral load, and physical status of human papillomavirus in liquid-based cytology samples from cervical lesions. Int J Gynecol Cancer 2008;18:121-7.
Sima N, Wang S, Wang W, Kong D, Xu Q, Tian X, et al. Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cells. Gynecol Oncol 2007;106:294-304.
Wentzensen N, Vinokurova S, von Knebel Doeberitz M. Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract. Cancer Res 2004;64:3878-84.
Scheffner M, Whitaker NJ. Human papillomavirus induced carcinogenesis and the ubiquitin-proteasome system. Semin Cancer Biol 2003;13:59-67.
Lee C, Laimins LA. Role of the PDZ domain-binding motif of the oncoprotein E6 in the patogénesis of human papillomavirus type 31. J Virol 2004;78:12366-77.
NguyenML, Nguyen MM, Lee D, Griep AE, Lambert PF. The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivo. J Virol 2003;77:6957-64.
Wisman GB, deJong S, Meersma GJ, Helder MN, Hollema H, de Vries EG, et al. Telomerasa in (pre)neoplastic cervical disease. Hum Pathol 2000;31:1304-12.
Lewin B. Chromosomes. En: Lewin B. Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall; 2004. p. 545-69.
Zimmermann S, Martens UM.Telomeres and telomerase as targets for cancer therapy. Cell Mol Life Sci 2007;64:906-21.
Talora C, Sgroi DC, Crum CP, Dotto GP. Specific down-modulation of notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev 2002;16:2252-63.
Yao J, Duan L, Fan M, Yuan J, Wu X.Notch1 induces cell cycle arrest and apoptosis in human cervical cancer cells: involvement of nuclear factor kappa B inhibition. Int J Gynecol Cancer 2007;17:502-10.
Wang L, Qin H, Chen B, Xin X, Li J, Han H. Overexpressed active Notch1 induces cell growth arrest of HeLa cervical carcinoma cells. Int J Gynecol Cancer 2007;17:1283-92.
Kuner R, Vogt M, Sultmann H, Buness A, Dymalla S, Bulkescher J, et al. Identification of cellular targets for the human papillomavirus E6 and E7 oncogenes by RNA interference and transcriptome analyses. J Mol Med 2007;85:1253-62.
How to Cite
Downloads
Downloads
Published
Issue
Section
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
