Preeclampsia in infertile patients subjected to homologous and heterologous insemination in the Centro de Biomedicina Reproductiva del Valle - Fecundar, Cali, Colombia
DOI:
https://doi.org/10.18597/rcog.203Keywords:
Preeclampsia, intrauterine insemination (IUI), donor semenAbstract
Objective: Determining preeclampsia incidence and risk in infertile patients who have been inseminated with semen from a donor or from their partner.
Materials and methods: This study dealt with historical cohorts of patients who had been subjected to homologous or heterologous intrauterine insemination in the Fecundar infertility centre and who had managed to become pregnant for more than 20 weeks gestation between January 2000 and 31st December 2009. Patients suffering endocrine and metabolic disorders (diabetes mellitus, collagen diseases) or chronic diseases (arterial hypertension, thrombophilia) were excluded. Sample size was 155 patients regarding heterologous insemination and 310 for homologous insemination.The presence of preeclampsia and perinatal result were evaluated and type of insemination, age, ethnicity, educational level, body mass index (BMI in Kg/m²), indication of insemination, number of prior cycles and socioeconomic strata were also measured. Accumulated incidence was estimated and two cohorts were compared by RR with respective confidence intervals. Females were stratified by age.
Results: 428 females fulfilled the selection criteria. There was 6% (24/428) preeclampsia incidence, 4% (11/264) homologous IUI and 7.93% (13/164) heterologous IUI. No differences were found regarding the risk of preeclampsia according to the type of insemination and after being adjusted for age (1.18 RR; 0.54-2.58 95%CI).
Conclusions: Greater preeclampsia incidence was found in heterologous IUI; however, there was no association with the development of preeclampsia.
Author Biographies
Jaime Saavedra-Saavedra
Eliana Paredes-Becerra
Paola Recalde-Losada
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