Antagonistas de receptores de progesterona (PRA) y moduladores selectivos de receptores de progesterona (SPRM): aplicaciones en ginecología y obstetricia

Autores/as

  • Diana Marcela Suárez-Calderón
  • Ivonne Díaz-Yamal

DOI:

https://doi.org/10.18597/rcog.428

Palabras clave:

receptores de progesterona, antiprogestina, mifepristone, asoprisnil, aborto, miomatosis, endometriosis, anticoncepción de emergencia

Resumen

Dos décadas de estudio bioquímico, farmacológico y clínico han permitido la síntesis de antagonistas del receptor de la progesterona (PRA) y moduladores selectivos de receptores de progesterona (SPRM).El receptor de progesterona (PR) comparte la estructura de los receptores esteroideos  que al ser estimulados sufren un cambio conformacional y subsecuentemente activan la transcripción genética en un tejido específico. Dicho proceso depende, particularmente en el PR, del equilibrio existente entre coactivadores y correpresores que ya han sido identificados. El mifepristone ha sido catalogado como PRA, mientras que el asoprisnil es el clásico SPRM agonista-antagonista. Múltiples estudios experimentales y clínicos han evidenciado la utilidad de los PRA y los SPRM en escenarios clínicos tan comunes como la miomatosis uterina, la endometriosis, la terminación del embarazo y la anticoncepción. Sin embargo, aún no existe la molécula ideal y faltan estudios que respalden la seguridad y eficacia de mifepristone y asoprisnil a largo plazo. El objetivo del presente documento es revisar la farmacodinamia y usos clínicos de estos medicamentos en ginecología y obstetricia.

Biografía del autor/a

Diana Marcela Suárez-Calderón

Ginecoobstetra Hospital Militar Central. Bogotá, Colombia.

Ivonne Díaz-Yamal

Coordinadora de la Unidad de Infertilidad Hospital Militar Central. Bogotá, Colombia.

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Cómo citar

1.
Suárez-Calderón DM, Díaz-Yamal I. Antagonistas de receptores de progesterona (PRA) y moduladores selectivos de receptores de progesterona (SPRM): aplicaciones en ginecología y obstetricia. Rev. colomb. obstet. ginecol. [Internet]. 31 de marzo de 2008 [citado 28 de marzo de 2024];59(1):31-7. Disponible en: https://revista.fecolsog.org/index.php/rcog/article/view/428

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2008-03-31

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