Clinical characteristics and prognosis of patients with cervical cancer treated in three healthcare centres in Barranquilla, Colombia, between 2005 and 2011

Authors

  • Robinson Fernández-Mercado
  • Jairo Amaya-Guío
  • Álvaro González-Rubio
  • Rafael Pineda-Vega
  • Elbert Riveros-Torrado
  • Angélica Álvarez-González
  • Jose M. Corro-Melgarejo

DOI:

https://doi.org/10.18597/rcog.60

Keywords:

Cervical cancer, squamous cell, adenocarcinoma, clinical stage, prognosis

Abstract

Objective: To describe the clinical characteristics and the prognosis of patients with cervical cancer treated in three healthcare centres in Barranquilla, Colombia.

Materials and methods: Descriptive retrospective cohort study. The databases of the three participating centres where reviewed to identify the cases with a diagnosis of CIE 10: malignant endocervical tumour, malignant exocervical tumour, malignant uterine cervical tumour, and malignant tumours of the uterine isthmus. Patients referred due to tumour relapse were excluded. Death certificates were used to confirm mortality cases. Absolute mortality is described by clinical stage. To establish prognosis, probability of disease-free survival at 1, 3 and 5 years of following was estimated.

Results: Overall, 375 patients diagnosed with cervical carcinoma were identified. Of them, 27 were lost to follow-up, for a total of 348 patients assessed. A rate of complications of approximately 19% was found, complications being more frequent among patients receiving radiotherapy (94%) than among those receiving surgical treatment (6%). The 5-year survival probability is 92% and the probability of being disease-free after five years is 89%.

Conclusions: Results in terms of complications and survival after treatment were similar to those reported in the literature. More studies and with a better methodological quality are required in order to characterize the prognosis for patients with cervical cancer in our population.

Author Biographies

Robinson Fernández-Mercado

Ginecólogo oncólogo. Docente de posgrado, Universidad Libre y Universidad Metropolitana de Barranquilla, Colombia

Jairo Amaya-Guío

Ginecoobstetra. Epidemiólogo Clínico. Profesor Asociado, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia

Álvaro González-Rubio

Ginecólogo-Oncólogo, Docente postgrado Universidad libre y Universidad Metropolitana de Barranquilla, Colombia

Rafael Pineda-Vega

Médico Epidemiólogo, Universidad Corpas, Bogotá, Colombia

Elbert Riveros-Torrado

Residente de ginecoobstetricia, tercer año, Universidad Metropolitana de Barranquilla, Colombia

Angélica Álvarez-González

Residente de ginecoobstetricia, tercer año, Universidad Metropolitana de Barranquilla, Colombia

Jose M. Corro-Melgarejo

Residente de ginecoobstetricia, tercer año, Universidad Metropolitana de Barranquilla, Colombia

References

Perkin DM, Bray F, Ferloy J, Pisani P. Eshmeting the world cancer burden globocan 2000. Int J Cancer. 2001:153-6.

Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA: A Cancer Journal for Clinicians. 2012; 62: 10-29. doi: 10.3322/caac.20138

Departamento Administrativo Nacional de Estadística de Colombia (DANE). Estadísticas Vitales 2010 [visitado 2013 enero 13]. Disponible en http://formularios.dane.gov.co/Anda_4_1/index.php/catalog/131.

Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Globocan 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. Lyon, France: International Agency for Research on Cancer; 2010. (Visitado 2013 enero 13). Disponible en: http://globocan.iarc.fr/.

Muñoz N, Franceschi S, Bosetti C, Moreno V, Herrero R, Smith JS et al. Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control study. Lancet. 2002;359:1093-101.

Cogliano V, Grosse Y, Baan R, Straif K, Secretan B, El Ghissassi F. Carcinogenicity of combined oestrogenprogestagen contraceptives and menopausal treatment. Lancet Oncol. 2005;6:552-3.

De San José, Palacio V, Tafur LA, Vásquez S, Espitia VE, Vázquez F, et al. Prostitution, HIV, and cervical neoplasia: a survey in Spain and Colombia. Cancer Epidemiol Biomarkers Prev. 1993;2:531-5.

Thun MJ, Apicella LF, Henley SJ. Smoking vs other risk factors as the cause of smoking-attributable deaths: confounding in the courtroom. JAMA. 2000;284: 706-1.

Suprasert P, Srisomboon J, Kasamutsu T, Radical Histerectomy for stage IIB cervical cancer; a review. Int Gynecol Cancer. 2005;15:995-1001.

Marin F, Pleşca M, Bordea CI, Voinea SC, Burlãnescu I, Ichim E, et al Postoperative surgical complications of lymphadenohysterocolpectomy. J Med Life. 2014;7:60-6.

Wang X, Liu R, Ma B, Yang K, Tian J, Jiang L, et al. High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer. Cochrane Database of Systematic Reviews 2010, Issue 7. Art. No.: CD007563. doi: 10.1002/14651858.CD007563.pub2.

Zobec-Logar HB, Segedin B, Hudej R. Definitive radiotherapy for uterine cervix cancer: Long term results for patients treated in the period from 1998 till 2002 at the Institute of oncology Ljubljana. Radiot Oncol. 2013;47:280-8.

Green JA, Kirwan JJ, Tierney J, Vale CL, Symonds PR, Fresco LL, et al. Concomitant chemotherapy and radiation therapy for cancer of the uterine cervix (review). The Cochrane Library 2012. Issue 2012.

The International Collaboration of Epidemiological Studies of Cervical Cancer (2007). Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies. Int J Cancer. 2006;120:885-91.

Parkin DM, Whelan SL, Ferlay J, Teppo L, Tomas DB, et al. Cancer incidence in five continents, vol. VIII. Lyon: IARC Press; 2002.

Lagasse LD, Creasman WT, Shingleton HM, Blessing JA. Results and complications of operative staging in cervical cancer: experience of the Gynecology Oncology Group. Gynecol Oncol. 1980;9:90-8.

Hockel M, Horn L-C, Fritsch H. Association between the management compartment of uterovaginal organogenesis and local tumor spread in stage IB – IIB cervical cancer: a prospective study. Lancet Oncol. 2005;6:751-6.

Chen Y, Xu H, Zhang Q, Li Y, Wang D, liang Z. A fertility-preserving option in early cervical carcinoma: laparoscopy-assisted vaginal radical trachelectomy and pelvic lynphadenectomy. Eur J Obstet Gynecol Reprod Biol. 2008;108:90-93.

Trimble EL, Harlan LC, Gius D, Stevens J, Schawartz SM. Patterns of care for women with cervical cancer in the United States. Cancer. 2008;113:743-9.

Neoadjuvant Chemotherapy for Cervical Cancer Metaanalysis Collaboration. Neoadjuvant chemotherapy for locally advanced cervical cancer: a systematic review and metaanalysis of individual patient data from 21 randomized trials. Euro J Cancer. 2003;39:2470-86.

How to Cite

1.
Fernández-Mercado R, Amaya-Guío J, González-Rubio Álvaro, Pineda-Vega R, Riveros-Torrado E, Álvarez-González A, et al. Clinical characteristics and prognosis of patients with cervical cancer treated in three healthcare centres in Barranquilla, Colombia, between 2005 and 2011. Rev. colomb. obstet. ginecol. [Internet]. 2014 Jun. 30 [cited 2024 May 17];65(2):120-8. Available from: https://revista.fecolsog.org/index.php/rcog/article/view/60

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Published

2014-06-30

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Original Research
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