Birth following in-vitro fertilization in a natural cycle
DOI:
https://doi.org/10.18597/rcog.509Keywords:
mature oocyte, ICSI, normal menstrual cycle, endometrium, gonadotropinsAbstract
The natural cycle combined with in-vitro fertilization (IVF) and embryo transfer (ET) has been shown to be an option providing great benefits, especially for patients aged more than 35 since treatment costs become reduced as hormones for controlled ovaric stimulation (COH) are not used and the risks of using gonadotropins are also avoided. Another benefit lies in embryos being transferred into an endometrial environment free of COH side effects.
Aim: describing successful pregnancy and the live birth of a healthy baby following IVF without COH in a natural cycle.
Procedure: a follicular ultrasound follow-up was performed on a patient having peritoneal tubal factor until the dominant follicle reached 16 mm and her endometrial thickness was over 14 mm. She then received 10,000 UI hCG and 36 hours later she underwent egg retrieval. A metaphase II (MII) oocyte was recovered from the dominant follicle and fertilized by ICSI. The embryo so obtained was then transferred to the uterus after 48 hours of culture, following previous endometrial preparation.
Results: a MII oocyte was recovered and fertilized by ICSI. It was transferred into the uterus when it reached the 4 blastomere grade I stage 48 hours after being retrieved. A quantitative pregnancy test was performed twelve days after the ET, resulting in a positive hCG. A healthy baby was born nine months later.
Conclusions: obtaining a mature oocyte without hormonal stimulation and then performing an embryo transfer in a natural cycle offers a new alternative for assisted reproductive techniques.
Author Biographies
Elkin Lucena
Carolina Lucena
Alejandro Rojas
Oscar Lombana
Zulma Suárez
Sandra Mojica
Angela María Saa
Diana Bernal
Abby Morán
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