Pre-eclampsia and cardiovascular risk: a follow-up study of the GenPE population in Colombia
DOI:
https://doi.org/10.18597/rcog.177Keywords:
Pre-eclampsia, obesity, dyslipidemia, metabolic syndrome, cardiovascular disease, cardiovascular riskAbstract
Introduction: Females having a background of pre-eclampsia (PE) are at greater risk of developing cardiovascular disease. The GenPE study has captured pregnant females with and without PE in Colombia during the last 10 years, making it possible today to evaluate cardiovascular outcomes in this group.
Objective: Determining the presence of cardiovascular disease in young females who were and were not exposed to preclampsia and who were recruited by the GenPE study carried out in Bucaramanga, Colombia.
Materials and methods: This was a cohort study which included 106 primiparous patients aged less than 26 years old having no background of chronic disease taken from an original cohort of 666 patients (2005-2010). They were physically examined and venopuncture was made for glycemia, lipid profile, uric acid and apolypoprotein A-I and B. The presence of hypertension, obesity, type 2 diabetes mellitus and metabolic syndrome were evaluated. Differences were established by Wilcoxon or Chisquared tests (relative risk and 95% CI) between females who had been exposed to PE and those who had not been so and the change between entering the GenPE study and the first follow-up.
Results: An association was found between exposure to PE and having higher diastolic pressure figures (p = 0.003) and hypercholesterolemia (p = 0.040). Sub-optimal HDL cholesterol and apo A-I levels were found in the whole population. No association with strong outcomes was found during the first follow-up, such as hypertension, obesity, type 2 diabetes mellitus or metabolic syndrome.
Conclusion: Changes in peripheral arterial disease (PAD) and cardiovascular risk-associated biomarkers became evident in a sample of young colombian females who developed PE during the first followup within 2 years after delivery.
Author Biographies
Norma Cecilia Serrano-Díaz
María Carolina Páez-Leal
Mónica Andrea Beltrán-Avendaño
Centro de Investigaciones Biomédicas, Universidad Autónoma de Bucaramanga (UNAB). Bucaramanga, Colombia.
Universidad Industrial de Santander (UIS). Bucaramanga, Colombia.
Claudia Carolina Colmenares-Mejìa
Elizabeth Guio-Mahecha
Paula Bautista-Niño
Colaboradores Lista completa al final del documento
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