Metronidazole use during the first trimester of pregnancy: a review
DOI:
https://doi.org/10.18597/rcog.631Keywords:
metronidazole, pregnancy, teratogenicityAbstract
Background: Metronidazole is used extensively in the obstetric patient due to the obstetric complications associated to bacterial vaginosis and trichomoniasis. However, physicians and patients alike hesitate to use metronidazole, especially during the first months of pregnancy fearing possible teratogenic effects.
Objective: To evaluate teratogenic risk of metronidazole during the first trimester of pregnancy.
Method: Review of medical literature on metronidazole use during the first trimester of pregnancy and its teratogenic effects.
Conclusion: Metronidazole exposure during the first trimester of pregnancy does not appear to increase the risk of overall birth defect occurrence.
Author Biography
Ralph Parrado
References
Schwebke JR. Metronidazole: utilization in the obstetric and gynecologic patient. Sex Transm Dis 1995;22(6):370-6.
Lossick JG, Kent HL. Trichomoniasis: trends in diagnosis and management. Am J Obstet Gynecol 1991;165:1217-22.
Joesoef MR, Schmid GP, Hillier SL. Bacterial vaginosis: review of treatment options and potential clinical indications for therapy. Clin Infect Dis 1999;28 Suppl 1:357-65.
AMA Drug Evaluations, Annual 1994, AMA. Philadelphia: WB Saunders Company. 1994.
Heisterberg L. Placental transfer of metronidazole in the first trimester of pregnancy. J Perinat Med 1984;12:43-5.
Burtin P, Taddio A, Aribumu O, Einarson TR, Koren G. Safety of metronidazole in pregnancy: a meta-analysis. Am J Obstet Gynecol 1995;172:525-29.
Beard CM,Noller KL, O´Fallon M, Kurland LT, Dockerty MB. Lack of evidence for cancer due to use of metronidazole. N Engl J Med 1979;301:519-22.
Caro-Paton T, Carvajal A, Martín de Diego I, Martín-Arias LH, Alvarez Requejo A, Rodríguez Pinilla E. Is metronidazole teratogenic? A meta-analysis. Br J Clin Pharmacol 1997;44(2):179.
Scott-Gray M. Metronidazole in obstetric practice. Obstet Gynecol 1964;71:82-5.
Piper JM, Mitchel EF, Ray WA. Prenatal use of metronidazole and birth defects: no association. Obstet Gynecol 1993;82:348-52.
Czeizel AE, Rockenbauer M. A population based case-control teratologic study of oral metronidazole treatment during pregnancy. Br J Obstet Gynaecol 1998;105:322-327.
Sorensen HT, Larsen H, Jensen ES, Thulstrup AM, Schonheyder HC, Nielsen GL, Czeizel A. Safety of metronidazole during pregnancy: a cohort study of risk of congenital abnormalities, preterm delivery and low birth weight in 124 women. J Antimicrob Chemother 1999;44:854-855.
Diav-Citrin O, Shechtman S, Gotteiner T, Arnon J, Ornoy A. Pregnancy outcome after gestational exposure to metronidazole: a prospective controlled cohort study. Teratology 2001;63(5):186-192.
Cantu JM, García-Cruz D. Midline facial defect as a teratogenic effect of metronidazole. Birth Defects 1982;18:85-8
Greenberg F. Possible metronidazole teratogenicity and clefting. Am J Med Genet 1985;22:825.
Schwebke JR. Metronidazole: Utilization in the Obstetric and Gynecologic Patient. Sexually Transm Diseases 1995;22:370-376.
Alper MM, Barwin BN, McLean WM, McGilveray IJ, Sved S. Systemic absorption of metronidazole by the vaginal route. Obstet Gynecol 1985;65:781-784.
How to Cite
Downloads
Downloads
Published
Issue
Section
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
