Measurement of myocardial oxygen consumption in normal postpartum: example of physiological efficiency
DOI:
https://doi.org/10.18597/rcog.517Keywords:
puerperium, oxygen consumption, myocardium, cardiovascular physiology, ventricular function, ColombiaAbstract
Objective: to determine the myocardial oxygen consumption (MVO2) in patients during early postpartum period, as a parameter of myocardial efficiency and to compare the results with the MVO2 values in healthy adult patients from other studies.
Methods: MVO2 was measured on 120 women in early postpartum without any pathology. Training set and test set groups were obtained in a retrospective and prospective manner respectively; subgroups were analyzed according to age, type of delivery and parity. EDOR formula was used for measurement of the MVO2. The measurements were compared with other studies on healthy patients.
Results: the average MVO2 on postpartum patients of our study was 6.58 ml/min-1/100 g-1 of tissue, with a maximum value of 7.33 ml/min-1/100 g-1 of tissue. Our study patients had statistically significant lower results of MVO2 when compared with healthy patients from other studies. There were not statistically significant MVO2 differences between the age, parity and type of delivery subgroups.
Conclusion: myocardial efficiency is evident during the postpartum period, with a high cardiac output associated with a low MVO2.
Author Biographies
Alejandro Castro
Adriana Paola Barriga
Omar Perdomo
References
Strauer BE. Myocardial oxygen consumption in chronic heart disease: role of wall stress, hypertrophy and coronary reserve. Am J Cardiol 1979;44:730-40.
Gómez A, Gómez H. Consumo de oxígeno del miocardio, una variable sofisticada, medida desde la cabecera del paciente, Protocolo de investigación. Universidad Nacional de Colombia, Facultad de Medicina; 2001.
Baller D, Breschneider HJ, Hellige G. A critical look at currently used indirect indices of myocardial oxygen consumption. Basic Res Cardiol 1981;76:163-81.
Katz R, Karliner JS, Resnik R. Effects of a natural volume overload state (pregnancy) on left ventricular performance in normal human subjects. Circulation 1978;58:434-41.
Shinke T, Takaoka H, Takeuchi M, Hata K, Kawai H, Okubo H, et al. Nitric oxide spares myocardial oxygen consumption through attenuation contractile response to beta-adrenergic stimulation in patients with idiopatic dilated cardiomyopathy. Circulation 2000;101:1925-30.
Sun KT, Yeatman LA, Buxton DB, Chen K, Johnson JA, Huang SC, et al. Simultaneous measurement of myocardial oxygen consumption and blood flow using (1-Carbon-11) acetate. J Nuc Med 1998;39:272-80.
Kameyama T, Asanoi H, Ishizaka S, Yamanishi K, Fujita M, Sasayama S. Energy conversion efficiency in human left ventricle. Circulation 1992;85:988-96.
Guyton A, Hall JE. Tratado de Fisiología Médica, 9a edición. Mexico: McGraw Hill-Interamericana; 1997.
Mak S, Newton GE. The oxidative stress hypothesis of congestive heart failure. Chest 2001;120:2035-46.
Zhang X, Xie YW, Nasjletti A, Xu X, Wolin MS, Hintze TH. ACE inhibitors promote nitric oxide accumulation to modulate myocardial oxygen consumption. Circulation 1997;95:176-82.
Sonntag H, Larsen R , Hilfiker O, Kettler D, Brockschnieder B. Myocardial blood flow and oxygen consumption during high-dose fentanyl anesthesia in patients with coronary artery disease. Anesthesiology 1982;56:417-22.
Beanlands RS, Nahmias C, Gordon E, Coates G, deKemp R, Firnau G, et al. The effects of beta(1)-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction. Circulation 2000;102:2070-5.
Kaye DM, Johnston L, Vaddadi B, Brunner-LaRoca H, Jennings GL, Esler MD. Mechanism of carvedilol action in human congestive heart failure. Hypertension 2001;37;1216-21.
Michaels AD, Klein A, Madden JA, Chatterjee K. Effects of intravenous nesiritide in human coronary vasomotor regulation and myocardial oxygen uptake. Circulation 2003;107:2697-701.
Braunwald E, Zipes DP, Libby P, eds. Braunwald’s Heart Disease. A Textbook of Cardiovascular Medicine. 6th edition; 2001.
Sun KT, Chen K, Huang SC, Buxton DB, Hansen HW, Kim AS, et al. Compartment model for measuring myocardial oxygen consumption using(1-11C) acetate. J Nuc Med 1997;38:459-66.
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