Quarterly lipid profiles in a populationof pregnant Colombian women
DOI:
https://doi.org/10.18597/rcog.462Keywords:
pregnancy, lipid metabolism, dyslipidemias, metabolism, hypertriglyceridemiaAbstract
Introduction: pregnancy is accompanied by changes in maternal lipoprotein metabolism which may serve for satisfying a foetus' nutritional demands.
Objective : studying quarterly lipid profile patterns in pregnant Colombian women.
Methods: total cholesterol, triglycerides and lipoproteins were investigated in this study in 422 healthy women during normal pregnancy in the first, second and third trimesters. Enzymatic methods were used for measuring cholesterol, triglycerides and lipoprotein concentrations in serum.
Results: triglycerides (128.2 ± 85.8; 238.6 ± 130.2; 305.1 ± 168.7 mg/dL), cholesterol (180.3 ± 70.8; 235.8 ± 72.5; 269.9 ± 107.5 mg/dL), very low density (25.6 ± 17.2; 47.5 ± 25.8; 59.9 ± 31.7 mg/dL) and low density lipoprotein (123.8 ± 69.2; 158.3 ± 77.6; 185.0 ± 102.6 mg/dL), increased from trimester by trimester. High density lipoprotein decreased (31.0 ± 13.4; 30.0 ± 12.8; 25.8 ± 10.3 mg/dL); this difference was significant (p values <0,001).
Conclusions: these results revealed metabolic changes in lipid profiles during pregnancy. This data will be used by physicians in following-up pregnant Colombian women who have an altered lipid profile, gestational diabetes, hypertension or other related diseases.
Author Biographies
Patricia Landázuri
Beatriz Restrepo
Juanita Trejos
Martha Lucía Gallego
Nelsy Loango Chamorro
Rodrigo Ocampo
References
Winkler K, Wetzka B, Hoffmann MM, Friedrich I, Kinner M, Baumstark MW, et al. Low density lipoprotein (LDL) subfractions during pregnancy: accumulation of buoyant LDL with advancing gestation. J Clin Endocrinol Metab 2000;85:4543-50.
Stock MJ, Metcalfe J. Maternal physiology during gestation. En: Knobil E, Neill JD, eds. The physiology of reproduction. New York: Raven Press; 1994. p. 947-83.
Rached De Paoli I, Azuaje A, Henriquez G. Cambios en las variables hematológicas y bioquímicas durante la gestación en mujeres eutróficas. An Venez Nutr 2002;15:11-7.
Osorio JH. Metabolismo de los lípidos durante el embarazo. Rev Colomb Obstet Ginecol 2000;51:113- 7.
Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). J Am Med Assoc 1986;256:2823-8.
Anderson KM, Wilson PW, Garrison RJ, Castelli WP. Longitudinal and secular trends in lipoprotein cholesterol measurements in a general population sample. The Framingham Offspring Study. Atherosclerosis 1987;68:59-66.
Castelli WP. Epidemiology of triglycerides: a view from Framingham . Am J Cardiol 1992;70:3H-9H.
Wang XL, McCredie RM, Wilcken DE. Common DNA polymorphisms at the lipoprotein lipase gene. Association with severity of coronary artery disease and diabetes. Circulation 1996;93:1339-45.
Sanduende Y, Figueira A, Rama-Maceiras P, Bautista A, Diéguez M. Pancreatitis hipertrigliceridémica y embarazo. Rev Esp Anestesiol Reanim 2003; 50:477-80.
Enquobahrie DA, Williams MA, Butler CL, Frederick IO, Miller RS, Luthy DA. Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia. Am J Hypertens 2004;17:574-81.
Enquobahrie DA, Williams MA, Qiu C, Luthy DA. Early pregnancy lipid concentrations and the risk of gestational diabetes mellitus. Diabetes Res Clin Pract 2005;70:134-42.
Valdés L, Rodríguez BR, Márquez A, Santana O, Robaina M, Lang J. Hiperlipidemias asociadas al embarazo en diabéticas y no diabéticas. Rev Cubana Endocrinol 2000;11:153-9.
Winocour PH, Ishola M, Durrington PN. Validation of the Friedewald formula for the measurement of low density lipoprotein cholesterol in insulin-dependent diabetes mellitus. Clin Chim Acta 1989;179:79-83.
Troisi A, Moles A, Panepuccia L, Lo Russo D, Palla G, Scucchi S. Serum cholesterol levels and mood symptoms in the postpartum period. Psychiatry Res 2002;109:213-9.
King JC. Physiology of pregnancy and nutrient metabolism. Am J Clin Nutr 2000;71(5 Suppl 5):1218S-25S.
Alvarez JJ, Montelongo A, Iglesias A, Lasuncion MA, Herrera E. Longitudinal study on lipoprotein profile, high density lipoprotein subclass, and postheparin lipases during gestation in women. J Lipid Res 1996;37:299-308.
Sattar N, Greer IA, Louden J, Lindsay G, McConnell M, Shepperd J, et al. Lipoprotein subfraction changes in normal pregnancy: threshold effect of plasma triglyceride on appearance of small, dense low density lipoprotein. J Clin Endocrinol Metab 1997;82:2483-91.
Martínez MP, Lozano JG. Hipertrigliceridemia y preeclampsia: papel fisiopatológico y evidencia actual.MedUNAB 2005;8:118-24.
Julius U, Fritsch H, Fritsch W, Rehak E, Fucker K, Leonhardt W, et al. Impact of hormone replacement therapy on postprandial lipoproteins and lipoprotein(a) in normolipidemic postmenopausal women. Clin Investig 1994;72:502-7.
Sánchez FR, Trelles E, Castañedo R, Lugones M. Índice de masa corporal en embarazadas adolescentes. Rev Cubana Med Gen Integr 2003;19(1).
Ramsay JE, Ferrell WR, Crawford I, Wallace AM, Greer IA, Sattar N. Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways. J Clin Endocrinol Metab 2002;87:4231-7.
Rodriguez J, Cediel V. Factores de riesgo cardiovascular en la población de Risaralda. 1a. edición. Pereira: Impresiones Litográficas; 2001.
Wierzbicki AS, Mikhailidis DP. Beyond LDL-c- the importance of raising HDL-C. Curr Med Res Opin 2002;18:36-44.
Hersberger M, von Eckardstein A. Low high-density lipoprotein cholesterol: physiological background, clinical importance and drug treatment. Drugs 2003;63:1907-45.
Sattar N, Petrie JR, Jaap AJ. The atherogenic lipoprotein phenotype and vascular endothelial dysfunction. Atherosclerosis 1998;138:229-35.
Sattar N, Bendomir A, Berry C, Shepherd J, Greer IA, Packard CJ. Lipoprotein subfraction concentrations in preeclampsia: pathogenic parallels to atherosclerosis. Obstet Gynecol 1997;89:403-8.
Hubel CA , Lyall F, Weissfeld L, Gandley RE, Roberts JM. Small low-density lipoproteins and vascular cell adhesion molecule-1 are increased in association with hyperlipidemia in preeclampsia. Metabolism 1998;47:1281-8.
Kaaja R, Tikkanen MJ, Viinikka L, Ylikorkala O. Serum lipoproteins, insulin, and urinary prostanoid metabolites in normal and hypertensive pregnant women. Obstet. Gynecol 1995;85:353-6.
Forest JC, Girouard J, Masse J, Moutquin JM, Kharfi A, Ness RB, et al. Early occurrence of metabolic syndrome after hypertension in pregnancy. Obstet Gynecol 2005;105:1373-80.
McGladdery SH, Frohlich JJ. Lipoprotein lipase and apoE polymorphisms: relationship to hypertriglyceridemia during pregnancy. J Lipid Res 2001;42:1905-12.
Casulari L, Wesgueber M, Silva R, Soares HF, Domingues L. Severe familial hypertriglyceridemia during pregnancy. Rev Bras Ginecol Obstet 2001;23:397-402.
Sattar N, Greer IA, Galloway PJ, Packard CJ, Shepherd J, Kelly T, et al. Lipid and lipoprotein concentrations in pregnancies complicated by intrauterine growth restriction. J Clin Endocrinol Metab 1999;84:128-30.
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