Altitude as a risk factor for neural tube defects (NTD)
DOI:
https://doi.org/10.18597/rcog.450Keywords:
congenital malformation, neural tube defect, altitudeAbstract
Objective: determining whether altitude is a risk factor for neural tube defects by comparing NTD prevalence amongst hospitals in the ECLAMC network in the cities of Cali and Bogotá in Colombia.
Methodology: this was a cross-sectional study using ECLAMC databases from the Valle Teaching Hospital in Cali and Hospital Simón Bolívar, Clinica Emmanuel, Hospital Universitario San Ignacio. Newborns delivered at these institutions between February 2004 and March 2005 were included in the study. Prevalence ratio was estimated.
Results: 7,201 births were registered at the Valle Teaching Hospital between February 2004 and March 2005 and 21 cases of newborns with NTD were identified (29.2 /10,000 newborn prevalence). 15,239 births were registered for the same period at the four institutions in Bogotá; 9 newborns having NTD were identified (6/10,000 live newborn prevalence). A statistically significant difference was observed for all forms of NTD (RR: 4.94; 95%CI: 2.26-10.78), markedly so for anencephaly (RR: 8.46; 95%CI: 1.80-39.85) and spina bifida (RR: 3.81; 95%CI: 1.28-11.36).
Conclusions: NTD prevalence was greater in cities lower than 2,000 metres above sea level, as previously reported in the literature.
Author Biographies
Wilmar Saldarriaga
Gonzalo Blanco-Tamayo
Diego Fernando Bravo-López
Andrés Manuel Díaz-Hung
Andrés Fandiño-Losada
Carolina Isaza
References
Stinson S. The effect of high altitude on the growth of children of high socioeconomic status in Bolivia. Am J Phys Anthropol 1982;59:61-71.
Wiley AS. Neonatal and maternal anthropometric characteristics in high altitude population of the western Himalaya. Am J Hum Biol 1994;6:499-510.
Wiley AS. Neonatal size and infant mortality at high altitude in the western Himalaya. Am J Phys Anthropol 1994;94:289-305.
Castilla EE, Lopez-Camelo J, Campaña H. Altitude as a risk factor for congenital anomalies. Am J Med Genet 1999;86:9-14.
Beall CM, Baker PT, Baker TS, Haas JD. The effect of high altitude on adolescent growth in Southern Peruvian Amerindians. Hum Biol 1977;49:109-24.
Leonard WR, De-Walt KM, Stansbury JP, McCaston MK. Growth differences between children of highland and coastal Ecuador. Am J Phys Anthropol 1995;98:47-57.
Castilla E, Orioli IM. ECLAMC: The latin-American collaborative study of congenital malformations. Community Genet 2004;7:76-94.
Wilson GN. Pediatric genetics: birth defect and sydromology. En: Clinical Genetics. New York, Chischester: Wiley Liss; 2000. p251-82.
Moore K, Persaud TVN. Embriología clínica. 6ª ed. México DF. Mc-Graw Hill; 2001. p477-517.
Ou CY, Stevenson RE, Brown VK, Schwartz CE, Allen WP, Khoury MJ, et al. 5, 10 methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects. Am J Med Genet 1996;63:610-4.
Gregory F. Genetic after of development. En: Nussbaum R, McInnes R, Willard H. Thompson and Thompson Genetics in medicine. 6th ed. Philadelphia: W.B. Saunders Co; 2001. p. 335-57.
Bianchi D, Crombleholme T, D’Alton M. Management of fetal conditions diagnosed by sonography. Section A: central nervous system. En: Fetology: diagnosis and management of the fetal patient. New York: Mc Graw Hill; 2000. p. 57-190.
Czeizel AE. Folic acid in the prevention of neural tube defects. J Pediatr Gastroenterol Nutr 1995;20:4-16.
Cortés F, Mellado C, Hertrampf E, Alliende A, Castillo S. Frecuencia de los defectos de cierre del tubo neural en las maternidades públicas de Santiago durante el año 1999. Rev Méd Chile 2001;129:277-84.
Castilla EE, Lopez-Camelo JE, Paz JE, Orioli IM. Prevención primaria de los defectos congénitos. Rio de Janeiro: Editora Fiocruz; 1996.
Berry RJ, Li Z, Erickson JD, Li S, Moore CA, Wang H, et al. Prevention of neural-tube defects with folic acid in China. China-U.S. collaborative project for neural tube defect prevention. N Engl J Med 1999;341:1485-90.
How to Cite
Downloads
Downloads
Published
Issue
Section
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
