The prevalence of squamous intraepithelial lesions amongst patients having atypical glandular cells. Colposcopic and histopathological findings from a reference institution in Bogotá, Colombia
DOI:
https://doi.org/10.18597/rcog.417Keywords:
atypical glandular cells, squamous intraepithelial lesions, endocervical curettage, colposcopyAbstract
Objectives: determining the prevalence of intraepithelial squamous lesions and the diagnostic validity of endocervical curettage in patients having cytology reporting atypical glandular cells.
Methods: a cross-sectional study was carried out from January 2000 to June 2006 at La Samaritana teaching hospital, this institution being classified as a third-level hospital in Bogotá, Colombia. Selection criteria consisted of complete information being available regarding the patients’ cytology concerning having atypical glandular cells, colposcopy and endocervical curettage. SPSS statistical software (version 15) was used for processing the data.
Results: the records of 105 women having had a positive cytology for atypical glandular cells were analysed. Cervical intraepithelial lesion prevalence was 53% in women having atypical glandular cells, 7% of them having high grade intraepithelial squamous lesions and 46.5% low grade lesions. Endocervical curettage revealed that 86.7% were negative for lesions and 13.3% had low grade intraepithelial lesions. 22 samples provided insufficient data. Histopathological exocervical epithelium results proved negative in 46.5% of cases; a similar 46.5% had low grade intraepithelial lesions and 7% high grade lesions. Agreement between exocervical biopsy and endocervical curettage resulted in a 0.07 Kappa score.
Conclusion: There was a high prevalence of intraepithelial cervical lesion, being found in 53% of women having atypical cells. None of these women had positive result for squamocellular carcinoma or adenocarcinoma.
Author Biographies
Eugenia Corredor-Sánchez
Marcos Castillo
References
Lawson HW, Hensen RM, Bobo JK, Kaeser MK. Implementing recommendations for the early detection of breast and cervical cancer among low income women. MMWR Recomm Re 2000;49:37-55.
República de Colombia. Ministerio de Salud. Resolución 412 del 2000. Norma técnica para la detección temprana del cáncer de cuello uterino y guía de atención de lesiones preneoplásicas de cuello uterino.
Lee KR, Darragh TM, Joste NE, Krane JF, Sherman ME, Hurley LB, et al. Atypical glandular cells of undetermined significance (AGUS). Interobserver reproducibility in cervical smears and corresponding thin-layer preparations. Am J Clin Pathol 2002;117:96-102.
Geier CS, Wilson M, Creasman W. Clinical evaluation of atypical glandular cells of undetermined significance. Am J Obstet Gynecol 2001;184:64-9.
Kaferle JE, Malouin JM. Evaluation and management of the AGUS Papanicolaou smear. Am Fam Physician 2001;63;2239-44.
Chin AB, Bristow RE, Korst LM, Walts A, Lagasse LD. The significance of atypical glandular cells on routine cervical cytologic testing in a community-based population. Am J Obstet Gynecol 2000;182:1278-83.
Irvin W, Evans SR, Andersen W, Jazaeri A, Taylor P, Stoler M, et al. The utility of HPV DNA triage in the management of cytological AGC. Am J Obstet Gynecol 2005;193:559-67.
Tam KF, Cheung AN, Liu KL, Ng TY, Pun TC, Chan YM, et al. A retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classification. Gynecol Oncol 2003;91:603-7.
Levine L, Lucci JA 3rd, Dinh TV. Atypical glandular cells: new Bethesda terminology and management guidelines. Obstet Gynecol Surv 2003;58:399-406.
Sharpless KE, Schnatz PF, Mandavilli S, Greene JF, Sorosky JI. Dysplasia associated with atypical glandular cells on cervical cytology. Obstet Gynecol 2005;105:494-500.
Mattosinho de Castro Ferraz Mda G, Focchi J, Stavale JN, Nicolau SM, Rodrigues de Lima G, Baracat EC. Atypical glandular cells of undetermined significance: cytologic predictive value for glandular involvement in high grade squamous intraepithelial lesions. Acta Cytologic 2003;47:154-8.
Kennedy AW, Salmieri SS, Wirth SL, Biscotti CV, Tuason LJ, Travarca MJ. Results of the clinical evaluation of atypical glandular cells of undetermined significance (AGCUS) detected on cervical cytology screening. Gynecol Oncol 1996;63:14-8.
Meath AJ, Carley ME, Wilson TO. Atypical glandular cells of undetermined significance: review of final histologic diagnoses. J Reprod Med 2002;47:249-52.
Mood NI, Eftekhar Z, Haratian A, Saeedi L, Rahimi-Moghaddam P, Yarandi F. A cytohistologic study of atypical glandular cells detected in cervical smears during cervical screening tests in Iran. Int J Gynecol Cancer 2006;16:257-61.
Sharpless KE, Schnatz PF, Mandavilli S, Greene JF, Sorosky JI. Lack of adherence to practice guidelines for women with atypical glandular cells on cervical cytology. Obstet Gynecol 2005;105:501-6.
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