Uterine carcinosarcoma with extension to the pelvis: Case presentation and review of the literature
DOI:
https://doi.org/10.18597/rcog.40Keywords:
Carcinosarcoma, uterine neoplasms, uterusAbstract
Objective: Presentation of a case of uterine carcinosarcoma and review of the literature on the epidemiology, diagnosis, treatment and prognosis of this neoplasm.
Materials and methods: A 73 year-old female patient presenting with vaginal bleeding, weight loss and a pelvic mass to a referral centre for gynaecological and obstetrical care in Cartagena, Colombia. The microscopic examination revealed a mixed malignant endometrial carcinosarcoma/ müllerian tumor. A systematic search was conducted in the Medline via PubMed, Hinari, Imbiomed, ScienceDirect and Ebsco databases, using the terms "carcinosarcoma", "uterine neoplasms", "uterus". The search included case reports, topic reviews or other studies published within the past 10 years, both in English and Spanish.
Results: Overall, 350 titles were found, 20 of which were directly related to the topic. Of these, 18 were selected, including 8 case reports, 7 topic reviews, 2 retrospective cohorts, and 1 clinical trial. Uterine carcinosarcoma is an infrequent neoplasm affecting post-menopausal women in particular. The histopathology shows a combination of carcinomatous and sarcomatous changes. The standard treatment is surgery. It has been suggested that the depth of invasion into de myometrium is a very important prognostic factor, and extra-uterine extension is found in 50% of cases. It is generally associated with very poor survival.
Conclusions: Carcinosarcoma is an infrequent neoplasm characterized by biphasic cell population and poor prognosis.
Author Biographies
César Redondo-Bermúdez
Liney Mendoza-Suárez
Karina Ruiz-Cáez
Jorge Gómez-Villa
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