Molecular aspects and mechanism of action regarding the use of fibrin sealants in laparoscopic gynecology: a literature review

Authors

  • Hernando Navarro-Newball
  • William García-Gutiérrez
  • Eliana Paredes-Becerra

DOI:

https://doi.org/10.18597/rcog.172

Keywords:

fibrin sealant, haemostatic, adhesive, gynecology, laparoscopy

Abstract

Objective: reviewing fibrin sealants’ biological activity and mechanism of action related to laparoscopic gynecology.

Materials and methods: a search was made of the literature published in both English and Spanish via PubMed/Medline, OVID and Cochrane from 1993 to 2010. Articles involving the use of sealants in laparoscopic gynecology were analyzed and grouped by topic, such as background, biological activity, composition, administration and biophysical characteristics.

Results: 200 articles were found which had been published from 1993 to 2010, 49 of them complied with the established analysis criteria. Fibrin sealants contributed towards achieving hemostasis, increasing plasminogen activator and inhibitor expression in peritoneal cells, thereby affecting curing, which could be beneficial in reducing post-operative adhesion.

Conclusion: developing fibrin sealants emerges as a practical alternative for reducing hemorrhage and controlling hemostasia, as well as reducing postoperative adhesion in surgery involving laparoscopic gynecology.

Author Biographies

Hernando Navarro-Newball

Ginecólogo Laparoscopista. Docente Universidad Libre, Cali (Colombia).

William García-Gutiérrez

Residente de IV año Ginecología y Obstetricia Universidad Libre. Cali, (Colombia)

Eliana Paredes-Becerra

Residente de IV año Ginecología y Obstetricia Universidad Libre. Cali, (Colombia)

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How to Cite

1.
Navarro-Newball H, García-Gutiérrez W, Paredes-Becerra E. Molecular aspects and mechanism of action regarding the use of fibrin sealants in laparoscopic gynecology: a literature review. Rev. colomb. obstet. ginecol. [Internet]. 2011 Dec. 20 [cited 2024 May 13];62(4):321-5. Available from: https://revista.fecolsog.org/index.php/rcog/article/view/172

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2011-12-20
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