Concordance study between placental alpha microglobulin-1 (PAMG-1) and insulin-like growth factor-1 (IGFBP-1) tests in patients with uncertain diagnosis of rupture of membranes, Medellín, Colombia

Authors

  • Hernán Cortés-Yepes

DOI:

https://doi.org/10.18597/rcog.1094

Keywords:

Premature rupture of membranes, diagnosis, diagnostic tests, indigo carmine

Abstract

Objective:To assess diagnostic concordance between placental alpha macroglobulin-1 (PAMGDOI 1) and insulin-like growth factor-binding protein 1 (IGFBP-1) tests in patients with uncertain diagnosis of rupture of membranes.

Materials and methods: Diagnostic concordance cross-sectional study in pregnant women with clinical suspicion of rupture of membranes seen at Hospital Universitario San Vicente Fundación de Medellín (HUSVF) between August 2014 and December 2015, in whom two diagnostic tests for the diagnosis of rupture of membranes were compared. Patients in advanced labour were excluded. Concordance of test results was estimated in terms of the presence or not of ruptured membranes, using the Kappa Index.

Results: Of 83 patients, 27.7 % were positive for rupture of membranes when the PAMG-1 (Amnisure) was used and 28.9 % were positive with the IGFBP-1 (Actim-Prom) test; the only case of disparity was positive to amniotic infusion of indigo
carmine. Concordance between both tests was 0.97.

Conclusion: The performance of IGFBP-1 was similar to that of PAMG-1 for diagnosing rupture of membranes.

Author Biography

Hernán Cortés-Yepes

Ginecólogo y Obstetra; especialista en Medicina Fetal. Docente, Universidad de Antioquia, Hospital Universitario de San Vicente Fundación, Medellín (Colombia). hcortes74@hotmail.com

References

ACOG. Premature rupture of membranes. ACOG Practice Bulletin No. 80. American College of Obstetricians and Gynecologists. Obstet Gynecol. 2007;109:1007-19.

Mercer BM. Preterm Premature Rupture of the Membranes. Obstet Gynecol. 2003;101:178-93.

Cortés H. Ruptura prematura de membranas. En: Cortés H, Gómez J, Gutiérrez J. Obstetricia: aspectos claves. CIB; 2013.

Guevara AM, Vergara MI, Gutiérrez JH, Sanín JE. Amnioinfusión con índigo carmín en sospecha de ruptura prematura de membranas ovulares pretérmino. Rev Colomb Obstet Ginecol. 2007;58:237-42.

Fujimoto S, Kishida T, Sagawa T, Negishi H, Okuyama K, Hareyama H, et al. Clinical usefulness of the dyeinjection method for diagnosing premature rupture of the membranes in equivocal cases. J Obstet Gynaecol (Tokyo). 1995;21:215-20.

McEnerney JK, McEnerney LN. Unfavorable neonatal outcome after intraamniotic injection of methylene blue. Obstet Gynecol. 1983;61(3 Suppl):35S-37S.

Smith RP. A technic for the detection of rupture of the membranes. A review and preliminary report. Obstet Gynecol. 1976;48:172-6.

Simhan HN, Canavan TP. Preterm premature rupture of membranes: diagnosis, evaluation and management strategies. BJOG. 2005;112(Suppl 1):32-7.

Di Renzo GC, Roura LC, Facchinetti F, Antsaklis A, Breborowicz G, Gratacos E, et al. Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth. J Maternal Fetal Neonatal Med. 2011;24:659-67. doi:10.3109/14767058.2011.553694.

Rutanen EM, Karkkainen TH, Lehtovirta J, Uotila J, Hinkula MK, Hartikainen AL. Evaluation of a rapid strip test for insulinlike growth factor-binding protein-1 in the diagnosis of ruptured of fetal membrane. Clin Chim Acta. 1996; 253:91-101.

Chen FC, Dudenhausen JW. Comparison of two rapid strip tests based on IGFBP-1 and PAMG-1 for the detection of amniotic fluid. Am J Perinatol. 2008;25:243-6. doi: 10.1055/s-2008-1066876.

Erdemoglu E, Mungan T. Significance of detecting insulinlike growth factor binding protein-1 in cervicovaginal secretions: comparison with nitrazine test and amniotic fluid volume assessment. Acta Obstet Gynecol Scand. 2004;83:622-6.

Jeurgens-Borst AJ, Bekkers RL, Sporken JM, van der Berg PP. Use of insulin like growth factor binding protein-1 in the diagnosis of ruptured fetal membranes. Eur J Obstet Gynecol Reprod Biol. 2002;102:11-4.

Cousins LM, Smok DP, Lovett SM, Poeltler DM. Amnisure placental a microglobulin-1 rapid immunoassay versus standard diagnostic methods for detection of rupture of membranes. Am J Perinatol. 2005;22:317-20.

Lee SE, Park JS, Norwitz ER, Kim KW, Park HS, Jun JK. Measurement of placental a-microglobulin-1 in cervicovaginal discharge to diagnose rupture of membranes. Obstet Gynecol. 2007;109:634-40.

Sosa CG, Herrera E, Restrepo JC, Strauss A, Alonso J. Comparison of placental alpha microglobulin-1 in vaginal fluid with intra-amniotic injection of indigo carmine for the diagnosis of rupture of membranes. J Perinat Med. 2014;42:611-6.

Wilfong L. Effects of maternal blood on the readability and reliability of the amnisure rapid immunoassay. Med Educ Foundation Am Coll Osteopathic Obstet Gynecol Winter Newslett. 2009; 30:11-2.

Cuartas A, Villa J, Cortés H, Tamayo J, Ossa B, Jaramillo A, et al. Diagnosis of preterm rupture of membranes with a rapid test that detects insulin-like growth factor binding protein 1 (IGFBP-1) and a comparison with indigo carmine amnioinfusion (en proceso de publicación).

Cortés-Reyes E, Rubio-Romero JA, Gaitán-Duarte H. Métodos estadísticos de evaluación de la concordancia y la reproducibilidad de pruebas diagnósticas. Rev Colomb Obstet Ginecol. 2010;61:247-55.

Liang DK, Qi HB, Luo X, Xiao XQ, Jia XY. Comparative study of placental X-microglobulin-1, insulin-like growth factor binding protein-1 and nitrazine test to diagnose premature rupture of membranes: a randomized controlled trial. J Obstet Gynaecol Res. 2014;40:1555-60. doi: 10.1111/jog.12381.

Pollet-Villard M, Cartier R, Gaucherand P, Doret M. Detection of Placental Alpha Microglobulin-1 versus Insulin-Like Growth Factor-Binding Protein-1 in Amniotic Fluid at Term: A Comparative Study. Am J Perinatol. 2011;28:489-94.

Tagore S, Kwek K. Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy. J Perinat Med. 2010;38:609-12. doi: 10.1515/JPM.2010.099.

How to Cite

1.
Cortés-Yepes H. Concordance study between placental alpha microglobulin-1 (PAMG-1) and insulin-like growth factor-1 (IGFBP-1) tests in patients with uncertain diagnosis of rupture of membranes, Medellín, Colombia. Rev. colomb. obstet. ginecol. [Internet]. 2016 Dec. 15 [cited 2024 May 18];67(4):299-304. Available from: https://revista.fecolsog.org/index.php/rcog/article/view/1094

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Published

2016-12-15

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Original Research
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