Inmunological profile and outcome of pregnancy at the first three-month period
DOI:
https://doi.org/10.18597/rcog.744Keywords:
Antiphospholipid antibodies, alloimmunity, autoimmunity, lymphocyte immunotherapyAbstract
The objective of this study was compare if the number and gestational age of previous abortions influenced the immunological diagnosis and the treatment of recurrently aborting patients. For this purpose, two groups of patients attending our Reproduction Program at The University of Antioquia were considered a) Those with only first-trimester recurrent spontaneous abortions and b) others with abortion occurring in different trimesters. Autoantibodies (antiphospholipid antibodies, lupus anticoagulant and antinuclear antibodies), alloimmunity (lack of mixed lymphocyte blocking factors) and the gestational outcome of the first pregnancy after joining to the program were compared. The history of two and three or more abortions was also analyzed. The immunological profile and the gestational outcome were similar in all groups.Author Biographies
Jorge Humberto Botero G.
Ángela P. Cadavid
Ruth Beatriz Peña A.
References
The recurrent miscarriage immunotherapy trialist group. Worldwide collaborative observational study and meta-analysis on allogenic immunotherapy for recurrent spontaneous abortion. Am J Reprod Immunol 1994; 32: 55-72.
Daya S, Gunby J. and the recurrent miscarriage immunotherapy trialist group. The effectiveness of allogenic leukocyte immunization in unexplained primary recurrent spontaneous abortion. Am J Reprod Immunol 1994; 32: 294-302.
McConnachie P. and McIntyre J. Maternal antipaternal immunity in couples predisposed to repeated pregnancy losses. Am J Reprod Immunol 1984; 5: 145-150.
Coulam C. Alternative treatment to lymphocyte immunization for treatment of recurrent spontaneous abortion. Immunotherapy with intravenous immunoglobulin of recurrent pregnancy loss: American experience. Am J Reprod Immunol 1994; 32: 286-289.
Espinel F, Mendoza JC, Cubillos J, Botero E. Autoinmunidad en pacientes con pérdida recurrente del embarazo. Rev Col Obstet Ginecol 1994; 45(2): 109-113.
Cadavid AP, Peña RB, Sánchez F, Botero J, Castañeda A, Ossa JE. Diagnóstico inmunológico y terapia del aborto recurrente espontáneo. Rev Colomb Obstet Ginecol 1996; 47 (3): 159-162.
Castañeda A, Cadavid AP, Peña RB, Sánchez F, Ossa J. Resultados de una segunda gestación en pacientes con aborto recurrente espontáneo, aloinmunizadas para su primera gestación. Medicina Reproductiva 1999; 2: 46-50.
Cadavid AP, Peña RB, García GP, Botero JH, Sánchez F, Ossa JE, Beer AE. Heparin plus aspirin as a "single" therapy for recurrent spontaneous abortion associated with both alloimmunity and autoimmunity. Am J Reprod Immunol 1999; 41: 271-278.
Kwak JY, Gilman-Sachs A, Beaman KD et al. Autoantibodies in women with primary recurrent spontaneous abortion of unknown etiology. J Reprod Immunol 1992; 22: 15-31.
Bahar AM, Kwak JY, Beer AE., et al. Antibodies to phospholipids and nuclear antigens in non-pregnant women with unexplained spontaneous recurrent abortions. J Reprod Immunol 1993; 24: 213-222.
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