Efecto del hábito de fumar sobre los resultados de laboratorio de la fertilización in vitro
DOI:
https://doi.org/10.18597/rcog.574Palabras clave:
tabaco, tabaquismo, nicotina, infertilidad, FIVResumen
Objetivo: evaluar la influencia del tabaquismo femenino, activo y pasivo, sobre los resultados de la fertilización in vitro (FIV) de mujeres fumadoras.
Diseño: estudio de cohorte.
Materiales y métodos: ciento diecinueve (119) parejas fueron sometidas a FIV, en primerintento, cuya indicación fue el factor tubario, fueron divididos en 3 grupos: mujeres no fumadoras (n=81), mujeres fumadoras pasivas (n=15) y mujeres fumadoras verdaderas (n=23). Los resultados de laboratorio de la FIV fueron analizados en separado.
Resultados: las mujeres fumadoras tuvieron un bajo índice de fertilización (40,7%) y mala calidad embrionaria (70,6%) en comparación con las no fumadoras (59,1% y 82,5%) y las fumadoras pasivas (67,4% y 87,9%) (p<0,05). No se ha encontrado diferencia en el numero de oocitos obtenidos y de embriones clivados entre los grupos.
Conclusiones: los resultados indican que el éxito de la FIV puede estar afectado negativamente en las fumadoras, donde el índice de fertilización es menor y la calidad embrionaria peor.
Biografía del autor/a
Adriana Arent
Mariangela Badalotti
Julia Machado
Rafaella Petracco
Alvaro Petracco
Referencias bibliográficas
Yach D, Bettcher D. Globalisation of tobacco industry influence and new global responses. Tob Control 2000;9:206-16.
The National Public Health Institute. Smoking Prevalence and Tobacco Policies in the Member States of the European Union. Helsinki: The Institute; 1997.
Ministério da Saúde. Instituto Nacional do Câncer. Prevalência de Tabagismo no Brasil. Dados dos inquéritos epidemiológicos em capitais brasileiras.Rio de Janeiro: O Instituto; 2004.
Hughes EG, Brennan BG. Does cigarette smoking impair natural or assisted fecundity? Fertl Steril 1996;66:679-89.
MacMahon B, Trichopoulus D, Cole P. Cigarette smoking and urinar y estrogens. N Engl J Med 1982;307:1062-5.
Sterzik K, Strehler E, De Santo M, Trumpp N, Abt M, Rosenbusch B, et al. Influence of smoking on fertility in women attending an in vitro fertilization program. Fertil Steril 1996;65:810-4.
Barbieri RL, McShane PM, Ryan KJ. Constituents of cigarette smoke inhibit human granulosa cell aromatase. Fertil Steril 1986;46:232-6.
Elenbogen A, Lipitz S, Mashiach S, Dor J, Levran D, Ben-Rafael Z. The effect of smoking on the outcome of in-vitro fertilization—embr yo transfer. Hum Reprod 1991;6:242-4.
Fredricsson B, Gilljam H. Smoking and reproduction. Short and long term effects and benefits of smoking cessation. Acta Obstet Gynecol Scand 1992;71:580-92.
Pattinson HA, Taylor PJ, Pattinson MH. The effect of cigarette smoking on ovarian function and early pregnancy outcome of in vitro fertilization treatment. Fertil Steril 1991;55:780-3.
Sharara FI, Beatse SN, Leonardi MR, Navot D, Scott RT Jr. Cigarette smoking acelarates the development of diminished ovarian reserve as evidenced by the clomiphene citrate challenge test. Fertil Steril 1994;62:257-62.
Jick H, Porter J. Relation between smoking and age of natural menopause. Report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. Lancet 1977;1:1354-5.
Neri A, Marcus SL. Effects of nicotine on the motility of the oviducts in the rhesus monkey: a preliminary report. J Reprod Fertil 1972;31:91-7.
Phipps WR, Cramer DW, Schiff I, Belisle S, Stillman R, Albrecht B, et al. The association between smoking and female infertility as influenced by cause of the infertility. Fertil Steril 1987;48:377-82.
Sasson JM, Haley NJ, Hoffman D, Wynder EL, Hellberg D, Nilsson S. Cigarette smoking and neoplasia of the uterine cervix:smoke constituents in cervical mucus. N Engl J Med 1985;312:315-6.
Klonoff-Cohen HK, Natarajan L, Marss R, Yee B. Effects of female and male smoking on success rates of IVF and gamete intra-Fallopian transfer. Hum Reprod 2001;16:1382-90.
Hughes EG, Yeo J, Claman P, YoungLai EV, Sagle MA, Daya S, et al. Cigarette smoking and the outcome of in vitro fertilization: measurement of effect size and levels of action. Fertil Steril 1994;62:807-14.
Rosevear SK, Holt DW, Lee TD, Ford WC, Wardle PG, Hull MG. Smoking and decreased fertilization rates in vitro. Lancet 1992;340:1195-6.
Neveu S, Hedon B, Bringer J, Chinchole JM, Arnal F, Humeau C, et al. Ovarian stimulation by combination of gonadotropin-releasing hormone agonist and gonadotropins for in vitro fertilization. Fertil Steril 1987;47:639-43.
Scott RT Jr, Rosenwaks Z. Ovulation induction for assisted reproduction. J reprod Med 1989;34:108-14.
Flood JT, Muasher SJ, Simonetti S, Kreiner D, Acosta AA, Rosenwaks Z. Comparison between laparoscopically and ultrasonographically guided transvaginal follicular aspiration methods in an in vitro fertilization program in the same patients using the same stimulation. J In Vitro Fert Embryo Transf 1989;6:180-5.
Rede Latino-americana de Reprodução Assistida. Manual de Procedimentos Laboratório de Reprodução Assistida. Santiago do Chile; 1998.
Weigert M, Hofstetter G, Kaipl D, Gottlich H, Krischker U, Bichler K, et al. The effect of smoking on oocyte quality and hormonal parameters of patients undergoing in vitro fertilization-embryo transfer. J Assist Reprod Genet 1999;16:287-93.
El-Nemr AL, Al-Shawaf T, Sabatini L, Wilson C, Lower AM, Grudzinskas JG. Effect of smoking on ovarian reserve and ovarian stimulation in in-vitro fertilization and embryo transfer. Hum Reprod 1998;13:2192-8.
Harrison KL, Breen TM, Hennessey JF. The effect of patient smoking habit on the outcome of IVF and GIFT treatment. Aust N Z J Obstet Gynaecol 1990;30:340-2.
Van Voorhis BJ, Syrop CH, Hammitt DG, Dunn MS, Snyder GD. Effects of smoking on ovulation induction for assisted reproductive techniques. Fertil Steril 1992;58:981-5.
Hughes EG, YoungLai EV, Ward SM. Cigarette smoking and outcomes of in-vitro fertilization and embryo transfer: a prospective cohort study. Hum Reprod 1992;7:358-61.
James VH. An hypothesis on the association between maternal smoking and dizygotic twinning. Hum Reprod 1997;12:1391-2.
Cómo citar
Descargas
Descargas
Publicado
Número
Sección
Estadísticas de artículo | |
---|---|
Vistas de resúmenes | |
Vistas de PDF | |
Descargas de PDF | |
Vistas de HTML | |
Otras vistas |