Embrioscopy in missed abortion

Authors

  • Jesús Alberto Ruíz-Ruíz
  • Eugenia Corredor-Sánchez
  • Carlos Julio García-Perlaza
  • José Ignacio Madero-Cervera
  • Claudia Rocío López
  • María Fernanda León
  • Magally Escobar

DOI:

https://doi.org/10.18597/rcog.493

Keywords:

embrioscopy, missed abortion, embryo, foetus, karyotype, chromosomal abnormality, chorionic villus

Abstract

Objective: showing the early experience and the findings in six patients suffering missed miscarriage having different weeks of gestation, who received transcervical embrioscopy before obstetric curettage whilst receiving the same anesthesia.

Institution: Medifértil, Bogotá, Colombia.

Type of Study: descriptive series of cases.

Materials and methods: kariotyping and trans-cervical embrioscopy was carried out on each of the six patients having a previous diagnosis of missed miscarriage, confirmed by transvaginal ultrasonography during the first three months.

Results: transcervical embrioscopy was successfully done on all the patients; four of them (66%) exhibited phenotype abnormalities, every case displayed a normal kariotype (analysis of 30 methaphases). One of the cases expressed a trisomy 21 and the other corresponded to hydropic degeneration related to partial mole.

Conclusion: We suggest applying transcervical embrioscopy before obstetric curettage in patients diagnosed as having early and recurrent loss as a complementary tool for identifying genetic abnormalities. It is also a procedure having low morbidity and uses the same hysteroscopy infrastructure.

Author Biographies

Jesús Alberto Ruíz-Ruíz

Director General. Medifertil Programa de Medicina Reproductiva. Bogotá, Colombia. Correo electrónico: medifertil@yahoo.com

Eugenia Corredor-Sánchez

Residente de 3er año de Ginecología y Obstetricia. Hospital la Samaritana. Bogotá, Colombia.

Carlos Julio García-Perlaza

Residente de 3er año de Ginecología y Obstetricia. Hospital la Samaritana. Bogotá, Colombia.

José Ignacio Madero-Cervera

Director Científico. Medifertil Programa de Medicina Reproductiva. Bogotá, Colombia.

Claudia Rocío López

Bacterióloga, Embrióloga. Laboratorio de Reproducción Asistida. Medifertil. Bogotá, Colombia.

María Fernanda León

Bacterióloga, Embrióloga. Laboratorio de Reproducción Asistida. Medifertil. Bogotá, Colombia.

Magally Escobar

Bacterióloga. Inmunóloga. Centro de Referencia en Infertilidad y Autoinmunidad. CERIA.

References

Speroff L, Fritz MA. Recurrent Early Pregnancy Loss. En: Clinical Gynecologic Endocrinology and Infertility. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2004. p. 1069-101.

Cullen MT, Reece A, Whetham JD, Hobbins JC. Embr yoscopy: description and utility of a new technique. Am J Obstet Gynecol 1990;162:82-6.

Philipp T, Philipp K, Reiner A, Beer F, Kalousek DK. Embryoscopic and cytogenetic analysis of 233 missed abortions: factors involved in the pathogenesis of developmental defects of early failed pregnancies. Hum Reprod 2003;18:1724-32.

Laing FC, Frapes MC. Evaluación ecográfica durante el primer trimestre del embarazo. En: Callen PW. Ecografía en Obstetricia y Ginecología. 4a. edición. Buenos Aires: Editorial Médica Panamericana; 2002. p. 126-34.

Lomax B, Tang S, Separovic E, Phillips D, Hillard E, Thomson T, et al. Comparative genomic hybridization in combination with flow cytometry improves results of cytogenetic analysis of spontaneous abortions. Am J Hum Genet 2000;66:1516-21.

Philipp T, Kalousek DK. Generalized abnormal embryonic development in missed abortion: embryoscopic and cytogenetic findings. Am J Med Genet 2002;111:43-7.

Ferro J, Martinez MC, Lara C, Pellicer A, Remohi J, Serra V. Improved accuracy of hysteroembryoscopic biopsies for karyotyping early missed abortions. Fertil Steril 2003;80:1260-4.

How to Cite

1.
Ruíz-Ruíz JA, Corredor-Sánchez E, García-Perlaza CJ, Madero-Cervera JI, López CR, León MF, et al. Embrioscopy in missed abortion. Rev. colomb. obstet. ginecol. [Internet]. 2006 Sep. 30 [cited 2024 May 11];57(3):207-10. Available from: https://revista.fecolsog.org/index.php/rcog/article/view/493

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Published

2006-09-30
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