Epidemiological surveillance of cyclopia in the Hospital Universitario del Valle, Cali, Colombia 2004-2008
DOI:
https://doi.org/10.18597/rcog.302Keywords:
cyclopia, holoprosencephaly, endemic, ECLAMCAbstract
Objectives: identifying and analysing cyclopia prevalence in the Hospital Universitario del Valle and searching for the aetiological factors described in the literature in the cases so found.
Methodology: this was a prospective study of cases and controls regarding cases of cyclopia occurring between December 2004 and April 2008 which were detected via HUV's congenital malformation epidemiological surveillance system, using Latin-American Collaborative Study of Congenital Malformations of births and cyclopy prevalence in the HUV were obtained. ECLAMC's interview form was used for searching for factors associated by the literature with cyclopy occurring. Photos were obtained in all cases.
Results: there were 18,224 births in the HUV from between December 2004 and April 2008; 8 of these presented cyclopy, giving a 1 in 2,278 births prevalence (43.8 per 100,000). All cases were classified as being Meyer type I. Three cases suffered from etmocephaly. Exposure to misoprostol, alcohol and marijuana was found in one case; diabetes in another; and marijuana in a third one. A case of trisomy 13 was presented and another case in which findings suggested trisomy 13, the karyotype was not obtained.
Conclusions: cyclopy in Cali and Valle del Cauca are endemic events. A congenital malformation, holoprosencephaly and cyclopy epidemiological surveillance system is needed for Cali and Valle del Cauca area.
Author Biography
Wilmar Saldarriaga
References
Shiota K, Yamada S, Komada M, Ishibashi M. Embryogenesis of holoprosencephaly. Am J Med Genet A 2007;143A:3079-87.
Yamada S. Embryonic holoprosencephaly: pathology and phenotypic variability. Congenit Anom (Kyoto) 2006;46:164-71.
Bianchi D, Crombleholme T, D Alton M. Fetology. New York: McGraw Hill; 2000 p. 493-98.
DeMyer WE. Holoprosencephaly (cyclopiaarhinencephaly). En: Vinken PJ, Bruyn GW, editors. Handbook of clinical neurology. Amsterdam: North Holland Publishing Company.1977. p. 431-78.
DeMyer W, Zeman W, Palmer CG. The face predicts the brain: diagnostic significance of median facial anomalies for holoprosencephaly (arhinencephaly). Pediatrics 1964;34:256-63.
Källén B, Castilla EE, Lancaster PA, Mutchinick O, Knudsen LB, Martínez-Frías ML, et al. The cyclops and the mermaid: an epidemiological study of two types of rare malformation. J Med Genet 1992;29:30-5.
Castilla EE, Orioli IM. ECLAMC: The Latin American collaborative study of congenital malformations. Community Genet 2004;7:76-94.
Kniffin C, McKusick V. Holoprosencephaly, OMIM®. Johns Hopkins University, Baltimore. [en línea] 1986 Mar 06 [Visitado en 2009 Sept 12]. Disponible en: http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=236100
Cohen MM Jr. The hedgehog signaling network. Am J Med Genet A 2003;123A:5-28.
Dubourg C, Bendavid C, Pasquier L, Henry C, Odent S, David V. Holoprosencephaly. Orphanet J Rare Dis 2007;2:8.
Münke M. Clinical, cytogenetic, and molecular approaches to the heterogeneity of holoprosencephaly. Am J Med Genet 1989;34:237-45.
Martínez-Frías ML, Bermejo E, Rodríguez-Pinilla E, Prieto L, Frías JL. Epidemiological analysis of outcomes of pregnancy in gestational diabetic mothers. Am J Med Genet 1998;78:140-5.
Cohen MM Jr, Shiota K. Teratogenesis of holoprosencephaly. Am J Med Genet 2002;109:1-15.
Pachajoa H, Tabares K, Quintero JC, Saldarriaga W, Isaza C. Diagnóstico prenatal de ciclopía asociado con trisomía 13. Colomb Med 2008;39:80-5.
Solano AF, Saldarriaga W, Isaza C, Mastroiacovo P, Castilla EE. Foco epidémico de sirenomelia en Cali, Colombia. Informe de 4 casos en el Hospital Universitario del Valle en 54 días. Colomb Med 2006;37:213-8.
Saldarriaga W, Isaza C, Mastroiacovo P, Castilla EE. Ciclopía en el Hospital Universitario del Valle: reporte de cuatro casos nacidos y revisión de la literatura. Rev Colomb Obstet Ginecol 2007;58:70-7.
Orioli IM, Mastroiacovo P, López-Camelo JS, Saldarriaga W, Isaza C, Aiello H, et al. Clusters of sirenomelia in South America. Birth Defects Res A 2009;85:112-8.
Castilla EE, Mastroiacovo P, López-Camelo JS, Saldarriaga W, Isaza C, Orioli IM. Sirenomelia and cyclopia cluster in Cali, Colombia. Am J Med Genet A 2008;146A:2626-36.
How to Cite
Downloads
Downloads
Published
Issue
Section
License
Copyright (c) 2016 Revista Colombiana de Obstetricia y Ginecología
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
