The association between the angiotensin converter enzyme (ACE), AT1R and AT2R receptor gene polymorphisms and breast cancer: a case control study
DOI:
https://doi.org/10.18597/rcog.229Keywords:
cancer, angiotensin converter enzyme (ACE), angiotensin receptor, genetic polymorphismAbstract
Introduction: breast cancer is the second most common type of cancer and the fifth cause of death due to cancer around the world. The components of the renin-angiotensin system are potential candidates for chemoprevention therapy: the angiotensin converter enzyme (ACE) and type 1 and 2 angiotensin II receptors (AT1R and AT2R).
Objective: establishing an association between ACE gene polymorphisms, AT1R and AT2R receptors and breast cancer.
Materials and methods: 50 cases and 50 controls were included and their genetic polymorphisms genotyped.
Results: genotype II occurred with greater frequency in controls than in the cases whilst the ID genotype had greater frequency in the cases (without having statistically significant differences). No type of additive effect of genotypes was found with the risk of breast cancer in the population being studied.
Conclusions: susceptibility to breast cancer has been described as being a complex phenomenon in which many genes may play an important role. In the case of the population studied here, the polymorphisms evaluated were not associated with breast cancer. Further studies having greater methodological rigor regarding this topic are required before changes in clinical practice can be proposed.
Author Biographies
Andrés Felipe Castro
Nelsy Loango
Bayron Ruíz
Patricia Landázuri
References
Perera NM, Gui GP. Multi-ethnic differences in breast cancer: current concepts and future directions. Int J Cancer 2003;106:463-7.
Prichard RS, Hill AD, Dijkstra B, McDermott EW, O'Higgins NJ. The prevention of breast cancer. Br J Surg 2003;90:772-83.
Instituto Nacional de cancerología. Cáncer en Cifras. Mortalidad por cáncer según primeras causas y sexo, Colombia 2000-2006. Visitado 2011 Ene 15. Disponible en: http://www.cancer.gov.co/contenido/contenido.aspx?catID=437&conID=790&pagID=774
Kenrick J. Gene Polymorphisms in the Renin-Angiotensin-Aldosterone System and Breast Carcinogenesis: Is there a Connection? TSMJ 2008;9:48-51.
Nathanson KL, Wooster R, Weber BL. Breast cancer genetics: What we know and what we need. Nat Med 2001;7:552-6.
Van der Knaap R, Siemes C, Coebergh JW, Van Dujin C, Hofman A, Stricker B. Renin-angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism, and cancer: the Rotterdam Study. Cancer 2008;112:748-57.
Fujita M, Hayashi I, yamashina S, Itoman M, Majima M. Blockade of angiotensin AT1a receptor signaling reduces tumor growth, angiogenesis, and metastasis. Biochem Biophys Res Commun 2002;294:441-7.
Alves Corrêa SA, Ribeiro de Noronha SM, Nogueirade-Souza NC, Valleta de Carvalho C, Massad Costa AM, Juvenal Linhares J, et al. Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptors (A1166C) polymorphisms and breast cancer among Brazilian women. J Renin Angiotensin Aldosterone Syst 2009;10:51-8.
Schmieder RE, Erdmann J, Delles C, Jacobi J, Fleck E, Hilgers K, et al. Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans. J Am Coll Cardiol 2001;37:175-82.
Humphries SE. Cooper, JA, Talmud PJ, Miller GJ. Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK Men. Clin Chem 2007;53:8-16.
Mendizábal-Ruiz AP, Morales JA, Castro Martinez X, Gutierrez Rubio SA, Valdez L, Vásquez-Camacho JG, et al. RAS polymorphisms in cancerous and benign breast tissue. J Renin Angiotensin Aldosterone Syst 2010. En prensa.
Lindpainter K, Pfeffer M, Kreutz R, Stampfer M, Grodstein F, LaMotte F, et al. A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med 1995;332:706-11.
Rigoli L, Chimenz R, di Bella C, Cavallaro E, Caruso R, Briuglia S, et al. Angiotensin-converting enzyme and angiotensin type 2 receptor gene genotype distributions in Italian children with congenital uropathies. Pediatr Res 2004;56:988-93.
Haiman CA, Henderson SO, Bretsky P, Kolonel LN, Henderson BE. Genetic variation in angiotensin I-converting enzyme (ACE) and breast cancer risk: the multiethnic cohort. Cancer Res 2003;63:6984-7.
Koh WP, yuan JM, Sun CL, van den Berg D, Seow A, Lee HP, et al. Angiotensin I-converting enzyme (ACE) gene polymorphism and breast cancer risk among Chinese women in Singapore. Cancer Res 2003;63:573-8.
González-Zuloeta AM, Arias-Vásquez A, Siemes C, yazdanpanah M, Coebergh JW, Hofman A, et al. Differential roles of Angiotensinogen and Angiotensin Receptor type 1 polymorphisms in breast cancer risk. Breast Cancer Res Treat 2007;101:299-304.
González-Zuloeta AM, Arias Vásquez A, Sayed-Tabatabaei FA, Coebergh JW, Hofman A, Njajou O, et al. Angiotensin-converting enzyme gene insertion/ deletion polymorphism and breast cancer risk. Cancer Epidemiol Biomarkers 2005;14:2143-6.
Koh WP, yuan JM, Van Den Berg D, Lee HP, yu MC. Polymorphisms in angiotensin II type 1 receptor and angiotensin I-converting enzyme genes and breast cancer risk among Chinese women in Singapore. Carcinogenesis 2005;26:459-64.
Imai N, Hashimoto T, Kihara M, yoshida S, Kawana I, yazawa T, et al. Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis. Lab Invest 2007;87:189-98.
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