Osseous metaplasia of the endometrium: case reports and literature review
DOI:
https://doi.org/10.18597/rcog.214Keywords:
osseous metaplasia, endometrial ossification, osseous ectopy, infertility, hysteroscopy, chronic pelvic pain, abnormal uterine hemorrhageAbstract
Objective: presenting two cases and reviewing the pertinent literature concerning the methods used in diagnosing the entity and its etiology.
Clinical cases: the cases were attended in the third-level San José teaching hospital where they had been referred due to infertility and chronic pelvic pain. Their echographies revealed hyperechogenic images in the endometrium. Hysteroscopy was performed, revealing multiple osseous formations floating within the endometrial cavity; these were extracted with grasper tweezers and their histological sections confirmed a diagnosis of osseous metaplasia of the endometrium. The first woman became pregnant 8 months later, delivering a healthy newborn at full-term; the second woman became pregnant twice but her attempts ended in complete early abortions.
Materials and methods: a search was made of MEDLINE databases via PUBMED, SciELO and Ovid, including articles published during the last 15 years.
Conclusion: osseous metaplasia is a cause of infertility involving cellular differentiation of secondary endometrial stromal (stem) cells leading to superoxide dismutase deficiency; this is suspected by transvaginal echography (ultrasound) and should be diagnosed and treated with hysteroscopy.
Author Biographies
Alba Lucía Mondragón-Cedeño
Ángel David Miranda-Cruz
Sergio Augusto Parra-Duarte
Eliana Paredes-Becerra
Ana María Zúñiga-Chávez
References
Peña D, Martínez A. La metaplasia ósea del endometrio como causa de esterilidad. Su manejo histeroscópico. Reporte de un caso. En: Monografias.com. Visitado 2011 May 16. Disponible en: http://www.monografias.com/trabajos33/metaplasia-osea-endometrio/metaplasia-osea-endometrio.shtml
Bahçeci M, Demirel LC. Osseous metaplasia of the endometrium: a rare cause of infertility and its hysteroscopic management. Hum Reprod 1996;11:2537-9.
Corvalán J, Sanhueza P. Metaplasia ósea endometrial: con sospecha diagnóstica ecográfica o histeroscópica. Rev Chil Obstet Ginecol 2002;67:30-3.
Vásquez H, Martínez O, Triana J. Metaplasia ósea como causa de infertilidad secundaria. Rev Obstet Ginecol Venez 2003;63:157-60.
Feyles V, Moyana TN, Pierson RA. Recurrent pregnancy loss associated with endometrial hyperechoic areas (endometrial calcifications): a case report and review of the literature. Clin Exp Obstet Gynecol 2000;27:5-8.
Shimizu M, Nakayama M. Endometrial ossification in a postmenopausal woman. J Clin Pathol 1997;50:171-2.
Gómez P, Beltrán L, Sánchez L. Metaplasia ósea endometrial: reporte de un caso. Rev Colomb Obstet Ginecol 1997;48:199-201.
Demeterco CP, Murata MK, Cequinel MG, Cornel CA, Francisco JF, Beduschi AF. Endometrial osseous metaplasia and primary infertility. Rev Bras Ginicol Obstet 2001;23:119-21.
Bravo E, Haberland J. Metaplasia ósea del endometrio como causa de infertilidad. Rev Chil Obstet Ginecol 2002;67:381-3.
Coccia ME, Becattini C, Bracco GL, Scarselli G. Ultrasound-guided hysteroscopic management of endometrial osseous metaplasia. Ultrasound Obstet Gynecol 1996;8:134-6.
Cayuela E, Perez-Medina T, Vilanova J, Alejo M, Cañadas P. True osseous metaplasia of the endometrium: the bone is not from a fetus. Fertil Steril 2009;91:1293.e1-4.
Tulandi T, Al-Sunaidi M, Arseneau J, Tonin PN, Arcand SL. Calcified tissue of fetal origin in utero. Fertil Steril 2008;89:217-8.
Vizoso F. Celulas madres uterinas. Visitado 2011 May 16. Disponible en: http://unahistoriaclinica.blogspot.com/2009/10/celulas-madre-uterinas-como-cura-de.html.
Aleman L. Principales enzimas antioxidantes. En: Monografias.com. Visitado 2011 May 16. Disponible en: http://www.monografias.com/trabajos24/enzimas-antioxidantes/enzimas-antioxidantes.shtml
Nevarez Bernal R, Vilchis Nava P, Kably Ambe A. Osificación endometrial: comunicación de cuatro casos y revisión bibliográfica. Ginecol Obstet Mex 2007;75:168-71.
Sugino N, Shimamura K, Takiguchi S, Tamura H, Ono M, Nakata M, et al. Changes in activity of superoxide dismutase in the human endometrium throughout the menstrual cycle and in early pregnancy. Hum Reprod 1996;11:1073-8.
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