25-hydroxy vitamin D serum levels in nonmenopausal, menopausal and postmenopausal females
DOI:
https://doi.org/10.18597/rcog.209Keywords:
vitamin D, 25-hydroxy vitamin D, menopauseAbstract
Objective: evaluating 25-hydroxy vitamin D (25OH vitamin D) serum levels in non-menopausal, menopausal and postmenopausal in females and their relationship with dome risk factors.
Materials and methods: this was an analytical, cross-sectional study of 113 females chosen consecutively when attending external consultation at a third-level hospital. Three groups were formed: group A, pre-menopausal aged 20-30 (n=40); group B, menopausal aged 45-55 (n=40); and group C, postmenopausal aged >65 (n=33) The levels of 25-OH vitamin D were compared in serum by ELISA and the relationship with smoking, exposure to the sun and physical activity during the last three months.
Results: 76% of the females had low 25-OH vitamin D (<25 nmol/L) levels; 80% of the females in group A had low levels compared to 77.5% from group B and 69.7% from group C (p=0.57). There were significant differences between the means of group B’s 25-OH vitamin D values compared to those of group A and C. Analysis of risk factors for reducing 25-OH vitamin D serum levels revealed no significant differences.
Conclusions: in spite of our geographical location in the tropics, females from age groups evaluated in this study had low 25-OH vitamin D levels.
Author Biographies
María Patricia Hormaza
Diana Cuesta
Lina María Martínez
Mónica María Massaro
María Nazareth Campo
María del Pilar Vélez
Gabriel Jaime Rendón
Camilo Andrés Agudelo
References
Bikle DD. Role of vitamin D, its metabolites, and analogs in the management of osteoporosis. Rheum Dis Clin North Am 1994;20:759-75.
Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005;293:2257-64.
Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, Staehelin HB, Bazemore MG, Zee Ry, et al. Effect of Vitamin D on falls: a meta-analysis. JAMA 2004;291:1999-2006.
Bischoff HA, Stähelin HB, Dick W, Akos R, Knecht M, Salis C, et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 2003;18:343-51.
Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, et al. Vitamin D and prevention of colorectal cancer. J Steroid Biochem Mol Biol 2005;97:179-94.
Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.
Banerjee P, Chatterjee M. Antiproliferative role of vitamin D and its analogs: a brief overview. Mol Cell Biochem 2003;253:247-54.
Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006;81:353-73.
Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet 1998;351:805-6.
Schneider DL. Vitamin D and Skeletal health. Curr Opin Endocrinol Diabetes 2006;13:483-90.
Rucker D, Allan JA, Fick GH, Hanley DA. Vitamin D insufficiency in a population of healthy western Canadians. CMAJ 2002;166:1517-24.
Kudlacek S, Schneider B, Peterlik M, Leb G, Klaushofer K, Weber K, et al. Assessment of vitamin D and calcium status in healthy adult Austrians. Eur J Clin Invest 2003;33:323-31.
Webb AR, Holick MF. The role of sunlight in the cutaneous production of vitamin D3. Annu Rev Nutr 1988;8:375-99.
Looker AC, Dawson-Hughes B, Calvo MS, Gunter EW, Sahyoun NR. Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone 2002;30:771-7.
Mezquita-Raya P, Muñóz-Torres M, Luna JD, Luna V, López-Rodríguez F, Torres-Vela E, et al. Relation between vitamin D insufficiency, bone density, and bone metabolism in healthy postmenopausal women. J Bone Miner Res 2001;16:1408-15.
González G, Alvarado JN, Rojas A, Navarrete C, Velásquez C, Arteaga E. High prevalence of vitamin D deficiency in Chilean healthy postmenopausal women with normal sun exposure: additional evidence for a worldwide concern. Menopause 2007;14:455-61.
Lamberg-Allardt CJ, Outila TA, Kärkkainen MU, Rita HJ, Valsta LM. Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe? J Bone Miner Res 2001;16:2066-73.
Tangpricha V. Vitamin D deficiency in the Southern United States. South Med J 2007;100:384-5.
Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int 2005;16:713-6.
Lewis S, Gómez A, Jimenez C, Veras L, Ma F, Lai S, et al. Vitamin D deficiency and seasonal variation in an adult south Florida population. J Clin Endocrinol Metab 2005;90:1557-62.
Binkley R, Novotny D, Krueger T, Kawahara Y, Daida YG, Lensmeyer G, et al. Low vitamin D status despite abundant sun exposure. J Clin Endocrinol Metab 2007;92:2130-5.
Matsuoka LY, Wortsman J, Dannenberg MJ, Hollis BW, Lu Z, Holick MF. Clothing prevents ultraviolet-B radiation-dependent photosynthesis of vitamin D3. J Clin Endocrinol Metab 1992;75:1099-103.
Mishal AA. Effects of different dress styles on vitamin D levels in healthy young Jordanian women. Osteoporos Int 2001;12:931-5.
Chen TC, Chimed F, Lu Z, Mathieu J, Person KS, Zhang A, et al. Factors that influence the cutaneous synthesis and dietary sources of vitamin D. Arch Biochem Biophys 2007;460:213-7.
Falch JA, Oftebro H, Haug E. Early postmenopausal bone loss is not associated with a decrease in circulating levels of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, or vitamin D-binding protein. J Clin Endocrinol Metab 1987;64:836-41.
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