Visión actual de la terapia de sustitución hormonal en la mujer posmenopáusica

Autores/as

  • John Jairo Zuleta

DOI:

https://doi.org/10.18597/rcog.558

Resumen

Durante casi una década se esperaron los resultados del estudio WHI (Women’s Health Initiative) que se suponía, brindarían información definitiva respecto al empleo de la terapia de reemplazo hormonal en la mujer menopáusica. Para sorpresa de la mayoría, a partir de julio de 2002 han aparecido informes de este estudio, que en general son contrarios a lo que se esperaba y a las creencias que se tenían previamente con respecto a los beneficios y a los riesgos de estas terapias. Las críticas y las posibles explicaciones a estos resultados no se hicieron esperar, y hoy existe bastante confusión al respecto, no sólo para los profesionales de la salud sino especialmente para las mujeres. En el presente artículo se hace una revisión de los aspectos metodológicos más relevantes del estudio WHI y se hace un análisis de las posibles explicaciones para la resistencia a aceptar sus resultados. Se concluye que el estudio tiene validez interna, sus resultados son importantes y la posibilidad de extrapolarlos es bastante alta; también, que en el momento, la única indicación aceptable para la terapia de sustitución hormonal es el control de la sintomatología vasomotora. Es necesario esperar otros reportes antes de aceptar como terapia de reemplazo otros preparados similares.

Biografía del autor/a

John Jairo Zuleta

Ginecoobstetra. Magister en Epidemiología Clínica. Profesor asistente del Departamento de Obstetricia y Ginecología y de la Escuela de Investigaciones Médicas de la Facultad de Medicina, Universidad de Antioquia.

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Cómo citar

1.
Zuleta JJ. Visión actual de la terapia de sustitución hormonal en la mujer posmenopáusica. Rev. Colomb. Obstet. Ginecol. [Internet]. 30 de marzo de 2005 [citado 2 de julio de 2022];56(1):46-58. Disponible en: https://revista.fecolsog.org/index.php/rcog/article/view/558

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Publicado

2005-03-30

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