Ovarian sex cord tumor with annular tubules: case report and review of the literature
DOI:
https://doi.org/10.18597/rcog.3888Keywords:
Gonadal sex cord and stromal tumors, ovarian cancer, Peutz-Jeghers syndromeAbstract
Objectives: To report a case of ovarian sex cord tumor with annular tubules (SCTAT) and conduct a literature review on diagnosis, treatment and prognosis of this condition.
Material and methods: Case report of a woman with a final diagnosis of advanced SCTAT seen at the National Cancer Institute in Bogota (Colombia) who received surgical treatment and chemotherapy with a satisfactory course after 6 months. A literature search was conducted in the Medline via PubMed, LILACS and Scielo databases, including case reports and series of women diagnosed with SCTAT published since 1990, not using age ranges. Information about diagnosis, treatment and reported prognosis was retrieved. A narrative summary of the findings was prepared.
Results: Fourteen publications with 26 patients were included. Mean age at diagnosis was 22.5 years. The main symptoms were menstruation abnormalities and pelvic pain. Computed tomography (CT) was the imaging technology most frequently used. Surgical treatment was used in all cases, together with chemotherapy in 29 %; 2 patients received radiotherapy. Recurrence occurred in 20 % of cases. Mortality was 12.5 %, with all deaths occurring within the first year.
Conclusions: There is a paucity of information about the diagnostic utility of imaging, tumor markers and histochemical studies, as well as prognosis of this disease condition. Surgery is the treatment of choice, taking into consideration the patient’s wishes regarding fertility, as well as the stage of the tumor. Further studies are needed to provide more detailed information about this condition.
Author Biographies
Franco Rafael Ruiz-Echeverría, Instituto Nacional de Cancerología, Bogotá (Colombia).
Fellow de Ginecología Oncológica. Universidad Militar Nueva Granada, Bogotá (Colombia). Instituto Nacional de Cancerología, Bogotá (Colombia).
María Islena Beltrán-Salazar, Instituto Nacional de Cancerología, Bogotá (Colombia).
Instituto Nacional de Cancerología, Bogotá (Colombia).
Pedro Hernando Calderón-Quiroz, Instituto Nacional de Cancerología, Bogotá (Colombia).
Instituto Nacional de Cancerología, Bogotá (Colombia).
Juan David Lalinde-Triviño, Instituto Nacional de Cancerología, Bogotá (Colombia).
Fellow de Ginecología Oncológica. Universidad Militar Nueva Granada, Bogotá (Colombia). Instituto Nacional de Cancerología, Bogotá (Colombia).
Maribel Palencia-Palacios, Universidad del Cauca, Popayán (Colombia).
Residente de Anatomía Patológica. Universidad del Cauca, Popayán (Colombia).
Oscar Suescún-Garay, Universidad Militar Nueva Granada, Bogotá (Colombia).
Fellow de Ginecología Oncológica. Universidad Militar Nueva Granada, Bogotá (Colombia).
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