Comparación del efecto tocolítico, in vitro, entre un anticálcico (nifedipina) versus un ß-agonista(terbutalina) en útero de rata. Estudio descriptivo. Informe preliminar

Authors

  • Reinaldo Acosta Cajiao
  • Tonny A. Sarquis Saad

DOI:

https://doi.org/10.18597/rcog.891

Keywords:

Estrogenized rat uterus, tocolysis, niedipine, terbutaline

Abstract

En útero de rata, previamente estrogenizado, se comparó el efecto tocolítico, nanomol a nanomol entre Terbutalina (ß agonista) y Nifedipina (anticálcico). El útero se estimuló con nueve dosis de 0,65 milunidades de oxitocina (dosis de contracción 50, previamente titulada en nuestro laboratorio), alternadas con seis diferentes infusiones de tres nanomoles de Terbutalina y tres nanomoles de Nifedipina. Se encontró que utilizando la misma dosis de ambos fármacos, existe un mayor· efecto tocolítico (disminución en el número de contracciones uterinas por minuto) con la Nifedipina que con la Terbutalina. La Nifedipina a pesar de nuevas infusiones de oxitocina, presentó un efecto tocolítico sostenido, no sucediendo lo mismo con la Terbutalina.

Author Biographies

Reinaldo Acosta Cajiao

Interno I Facultad de Medicina. Universidad Javeriana. Monitor del Departamento de Ciencias Fisiológicas. Facultad de Medicina. Universidad Javeriana

Tonny A. Sarquis Saad

Estudiante VII semestre. Facultad de Medicina. Universidad Javeriana. Monitor del Departamento de Ciencias Fisiológicas. Facultad de Medicina. Universidad Javeriana. Santafé de Bogotá. D.C.

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How to Cite

1.
Acosta Cajiao R, Sarquis Saad TA. Comparación del efecto tocolítico, in vitro, entre un anticálcico (nifedipina) versus un ß-agonista(terbutalina) en útero de rata. Estudio descriptivo. Informe preliminar. Rev. colomb. obstet. ginecol. [Internet]. 1992 Sep. 30 [cited 2024 May 16];43(3):214-8. Available from: https://revista.fecolsog.org/index.php/rcog/article/view/891

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1992-09-30
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