Early detection of cervical intraepithelial lesions in women from Caldas, Colombia, by electrical impedance spectroscopy

Authors

  • Germán Olarte-Echeverri
  • William Aristizábal-Botero
  • Paula Andrea Gallego-Sánchez
  • Jerónimo Rojas-Díaz
  • Beatriz Eugenia Botero
  • Gloria Fátima Osorio

DOI:

https://doi.org/10.18597/rcog.487

Keywords:

impedance spectroscopy, cervical intraepithelial lesion

Abstract

Objective: testing electrical impedance spectroscopy’s diagnostic precision in detecting cervical intraepithelial lesions.

Methodology: this was a diagnostic validity test using a cross-sectional study. 285 patients were evaluated; 118 from this group were selected who were non-menopausic and had abnormal cytology, without biopsies or previous treatment of the cervix. Curves were obtained of resistance magnitude (Ω -m) cf frequency (kHz). This led to differentiating tissue types and the degrees of lesion.

Results: it was found from the so obtained parameters that extracellular liquid R resistance was the best discriminator of healthy squamous epithelium and tissue affected by CIN-1 and CIN-2/3 type lesions. Average R value for healthy squamous tissue was 24.31 Ω-m (11.26 standard deviation, 46.3%variation coefficient), 9.76 Ω-m average value for tissue having CIN-1 lesions (6.52 standard deviation, 66.8% variation coefficient) and 6.12 Ω-m average value for tissues having CIN-2/3 lesions (4.32 standard deviation, 70.6% variation coefficient). This diagnostic technique’s precision was measured by receiver-operating characteristic (ROC) curves, differentiating normal squamous tissues from CIN-1 (79.3% sensitivity and 79.1% specificity). Sensitivity was 88.4% and specificity 87.1% between normal squamous tissues and CIN-2/3 and 63.8% sensitivity and 63.6% specificity between CIN-I and CIN-2 and –3.

Author Biographies

Germán Olarte-Echeverri

Médico Ginecólogo - oncólogo. Universidad de Caldas. Programa cáncer de cuello uterino y cáncer de mama - Facultad de Ciencias para la Salud, Universidad de Caldas.

William Aristizábal-Botero

Ingeniero electricista, candidato a Ph. D. en Bioingeniería. Universidad de Caldas. Laboratorio de instrumentación biofísica –Departamento de Física -Facultad de Ciencias Exactas y Naturales, Universidad de Caldas.

Paula Andrea Gallego-Sánchez

Médica y cirujana. Universidad de Caldas. Programa cáncer de cuello uterino y cáncer de mama - Facultad de Ciencias para la Salud, Universidad de Caldas.

Jerónimo Rojas-Díaz

 Ingeniero electrónico. Universidad de Caldas. Laboratorio de instrumentación biofísica - Departamento de Física - Facultad de Ciencias Exactas y Naturales, Universidad de Caldas.

Beatriz Eugenia Botero

 Enfermera superior. MSc en Salud Pública. Universidad de Caldas. Programa cáncer de cuello uterino y cáncer de mama - Facultad de Ciencias para la Salud, Universidad de Caldas.

Gloria Fátima Osorio

Médica y cirujana especialista en patología humana. MSc en Educación. Programa Universidad de Caldas. Programa cáncer de cuello uterino y cáncer de mama - Facultad de Ciencias para la Salud, Universidad de Caldas.

References

Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 1999;80:827-41.

Parkin DM, Whelan SL, Ferlay J, Teppo L, Thomas DB (eds). Cancer incidence in five continents. Vol. V3, IARC Scientific Publications Nº 155. Lyon: IARC; 2003.

Vizcaino AP, Moreno V, Bosch FX, Munoz N, Barros-Dios XM, Borras J, et al. International trends in incidence of cervical cancer: 2. Squamous-cell carcinoma. Int J Cancer 2000;86:429-35.

Piñeros M, Ferlay J, Murillo R. Incidencia estimada y mortalidad por cáncer en Colombia, 1995-1999. Instituto Nacional de Cancerología, International Agency for Research on Cancer, Ministerio de la Protección Social; 2005.

López G, Arango G, Marin A, Vanegas ML, Agudelo LM, Escobar AM, et al. Registro Poblacional de Manizales-Caldas. Año 2003. Gobernación de Caldas, Alcaldía de Manizales, Universidad de Caldas, Instituto Nacional de Cancerología; 2005.

Nanda K, McCrory DC, Myers ER, Bastian L A, Hasselblad V, Hickey JD, et al. Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review. Ann Intern Med 2000;132:810-9.

Brown BH, Tidy JA, Boston K, Blackett AD, Smallwood RH, Sharp F. Relation between tissue structure and imposed electrical current flow in cervical neoplasia. Lancet 2000;355:892-5.

Jones DM, Smallwood RH, Hose DR, Brown BH, Walker DC. Modelling of epithelial tissue impedance measured using three different designs of probe. Physiol Meas 2003;24:605-23.

Abdul S, Brown BH, Milnes P, Tidy JA. A clinical study of the use of impedance spectroscopy in the detection of cervical intraepithelial neoplasia (CIN). Gynecol Oncol 2005;99(3 suppl 1):S64-6.

Cole KS, Cole RH. Dispersion and absorption in dielectrics. I. Alternating current characteristics. J Chem Phys 1941;9:341-51.

Dominguez E, González R. Análisis de las curvas Receiver-Operating characteristic: un método útil para evaluar procedimientos diagnósticos. Rev Cubana Endocrinol 2002;13:169-76.

How to Cite

1.
Olarte-Echeverri G, Aristizábal-Botero W, Gallego-Sánchez PA, Rojas-Díaz J, Botero BE, Osorio GF. Early detection of cervical intraepithelial lesions in women from Caldas, Colombia, by electrical impedance spectroscopy. Rev. colomb. obstet. ginecol. [Internet]. 2007 Mar. 30 [cited 2024 May 16];58(1):13-20. Available from: https://revista.fecolsog.org/index.php/rcog/article/view/487

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Published

2007-03-30

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Original Research
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