Prevalence of high-risk human papilloma virus infection and abnormal cytology of the anal transformation zone in women with cervical dysplasia. Bogotá, Colombia, 2017-2019
DOI:
https://doi.org/10.18597/rcog.3558Abstract
Objective: To determine the prevalence of anal infection caused by high-risk human papilloma virus (HR-HPV) and of abnormal anal cytology in women with confirmed cervical dysplasia. Materials and methods: Cross-sectional study that included patients between 30 and 65 years of age with a new diagnosis of cervical dysplasia by histopathology attended in two lower genital tract colposcopy and pathology units (one public and one private institution), conducted between December 2017 and April 2019. Women with human immunodeficiency virus (HIV) infection, immune compromise (use of steroids, transplant, chemotherapy), pregnancy or anorectal malformations were excluded. Consecutive sampling. Sociodemographic variables, intercourse type, degree of cervical dysplasia, positive results of HR HPV Polymerase Chain Reaction test in anal canal and HR - HPV type indentified (16-18 or others) were evaluated. Descriptive statistics were used. Results: Of 188 candidates, 100 were included in the analysis. A 32 % prevalence of high-risk HPV infection and a 2.8 % prevalence of abnormal cytology in the anal canal (ASCUS) were found. Of the HR-HPV infections in the anal canal, 68.8 % corresponded to HR-HPV genotypes different from 16 or 18. Conclusions: Prevalence of HR HPV infection in women with lower genital tract dysplasia was 32%. It is important to determine the usefulness of screening for anal mucosa compromise by HPV virus associated with a high risk of cancer in women with cervical dysplasia. Studies are needed on the prognosis of anal HR-HPV infection in women with cervical dysplasia.
Author Biographies
Cristhiam David Sánchez-Corredor, Universidad Nacional de Colombia, Bogotá (Colombia).
Especialista en Obstetricia y Ginecología, Universidad Nacional de Colombia, Bogotá (Colombia).
Mónica Guerrero-Machado, Fundación Universitaria de Ciencias de la Salud, Bogotá (Colombia).
Especialista en Obstetricia y Ginecología, Universidad Nacional de Colombia; especialista en Cirugía Endoscópica Ginecológica, Fundación Universitaria de Ciencias de la Salud, Bogotá (Colombia).
Jorge Andrés Rubio-Romero, Universidad Nacional de Colombia, Bogotá (Colombia).
Especialista en Ginecología y Obstetricia; magíster en Epidemiología Clínica. Profesor titular, Departamento de Obstetricia y Ginecología, Universidad Nacional de Colombia, Bogotá (Colombia).
Edith Ángel-Müller, Universidad Nacional de Colombia, Bogotá (Colombia).
Especialista en Ginecología y Obstetricia. Profesora titular, Departamento de Obstetricia y Ginecología, Universidad Nacional de Colombia, Bogotá (Colombia).
Gustavo Rey-Serrano, Universidad Nacional de Colombia, Bogotá (Colombia).
Especialista en Obstetricia y Ginecología, Universidad Nacional de Colombia; magíster en Salud Sexual y Reproductiva, Universidad El Bosque, Bogotá (Colombia).
Luz Amparo Díaz-Cruz, Universidad Nacional de Colombia, Bogotá (Colombia).
Especialista en Ginecología y Obstetricia. Profesora asociada, Departamento de Obstetricia y Ginecología, Universidad Nacional de Colombia, Bogotá (Colombia).
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Dirección de Investigación, Universidad Nacional de Colombia
Grant numbers DIB: 35975
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