The effect of age on the male factor and its outcome regarding couples' fertility
DOI:
https://doi.org/10.18597/rcog.341Keywords:
spermogram, astenozoospermy, infertility, teratozoospermyAbstract
Objective: analysing abnormalities in seminal parameters and their correlation with age through spermograms of patients admitted to the GESTAMOS Reproductive Medicine Unit for infertility.
Methods and materials: this was a descriptive cross-sectional study of 226 spermogramscollected between January 2005 and January 2008. They were examined by standard analysis according to WHO guidelines and CECOLFES Fertility and Sterility Centre's Andrology Laboratory protocol. BioStat® 2007 statistical analysis software was used for analysing Pearson correlation Indices.
Results: a total of 226 spermograms presented 73,5% significant changes in all their parameters. Decreased rapidly progressive mobility (astenozoospermy) was observed in 65% and such downward trend was related to age (0,04% per year). Abnormalities in sperm morphology (teratozoospermy) were presented in 52,2%, having an upward trend (0,02% per year). Decreased sperm concentration was observed in 28% (0,01 x 106/mL per year decrease).
Conclusions: there was a significant decrease in the study population's sperm quality which was greater than that reported in the literature. This was more relevant in the sense that as patients' age increased then the rapidly progressive mobility and morphology of their sperm became most affected, this being closely related to patients' fertilising capacity.
Author Biographies
Diana Fontanilla
Jenny Ramírez
Armando Dávila
Juan Rodríguez
Carolina Arenas
Elkin Lucena
References
Baird DT, Collins J, Egozcue J, Evers LH, Gianaroli L, Leridon H, et al. Fertility and ageing. Hum Reprod Update 2005;11:261-76.
Barroso G, Chaya M, Bolaños M, Rosado Y, García-León F, Ibarrola E. Valor pronóstico en las tasas de recuperación para la aplicación de técnicas de preparación seminal y su evaluación en la función espermática. Ginecol Obstet Mex 2005;73:221-8.
Bishop MW. Ageing and reproduction in the male. J Reprod Fertil Suppl 1970;12:65-87.
Brugo Olmedo S, Chillik C, Kopelman S. Definición y causas de la infertilidad. Rev Colomb Obstet Ginecol 2003;54:227-48.
Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for decreasing quality of semen during the past 50 years. BMJ 1992;305:609-13.
CocuzzaM,AtheydeKS,AgarwalA,SharmaR,Pagani R, Lucon AM, et al. Age-related increase of reactive oxygen species in neat semen in healthy fertile men. Urology 2008;71:490-4.
Coetzee K, Kruger T, Lombard CJ. Predictive value of normal sperm morphology: a structured literature review. Hum Reprod Update 1998;4:73-82.
Dávila A, Saa A. Factor masculino en infertilidad. En: Texto de Obstetricia y Ginecología. Primera edición. Bogotá: Sociedad Colombiana de Obstetricia y Ginecología; 2004. p. 751-58.
De Los Ríos J, Arenas A, Ochoa C, Giraldo A. Análisis de la infertilidad masculina de los pacientes que consultaron al servicio de urología de Profamilia -Medellín. Medellín (Colombia): Universidad de Antioquia, Profamilia; 2006.
Delgadillo LF, Laverde E. Infertilidad masculina. Bogotá: Universidad El Bosque. Tesis Doctoral; 1995.
Eskenazi B, Wyrobek AJ, Sloter E, Kidd SA, Moore L, Young S, et al. The association of age and semen quality in healthy men. Hum Reprod 2008;18:447-54.
Gallardo E, Simón C, Levy M, Guanes PP, Remohí J, Pellicer A. Effect of age on sperm fertility potential: oocyte donation as a model. Fertil Steril 1996;36:146-66.
Gao J, Gao ES, Yang Q, Walker M, Wu JQ, Zhou WJ, et al. Semen quality in a residential, geographic and age representative sample of healthy Chinese men. Hum Reprod 2007;22:477-84.
Irvine DS.Epidemiology and aetiology of male infertility. Hum Reprod 1998;13:33-44.
Nallella KP, Sharma RK, Aziz N, Agarwal A. Significance of sperm characteristics in the evaluation of male infertility. Fertil Steril 2006;85:629-34.
Organización Mundial de la Salud. Manual de laboratorio de la OMS para el examen del semen humano y de la interacción entre el semen y el moco cervical. Editorial Médica Panamericana; 2001.
BioStat® 2007. Disponible en: http://www.analystsoft.com/en/products/biostat
Patton PE, Bataglia DE. Contemporary endocrinology: Office andrology. New Jersey: Humana Press Inc; 2005.
Lowe X, Eskenazi B, Nelson DO, Kidd S, Alme A, Wyrobek AJ. Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome. Am J Hum Genet 2001;69:1046-54.
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