Placental site tumour associated with IgA nephropathy as paraneoplastic manifestation: case report
DOI:
https://doi.org/10.18597/rcog.3132Keywords:
IgA glomerulonephritis, nephrotic syndrome, placental site trophoblastic tumourAbstract
bjective: To report the case of a placental site tumour which presented clinically in the form of a nephrotic syndrome secondary to IgA nephropathy.
Case presentation: A 24-year-old woman, primigravida, referred to a Level IV complexity institution in Bogotá (Colombia), where she was diagnosed with IgA nephropathy as a paraneoplastic manifestation of a placental site trophoblastic tumour. After total hysterectomy as treatment, the patient evolved well, with oedema resolution and a drop in proteinuria. The patient completed one year of medical follow-up and with no evidence of disease.
Discussion: Placental site trophoblastic tumour is rare, is part of the differential diagnosis for gestational trophoblastic disease and may present as a renal paraneoplastic manifestation which usually resolves once the tumour is treated. IgA nephropathy may be secondary to chronic inflammatory diseases and neoplastic diseases, as in this case.Author Biographies
Kateir Mariel Contreras-Villamizar
Médica internista y nefróloga, Servicio de Medicina Interna, Unidad de Nefrología, Hospital Universitario San Ignacio, Bogotá (Colombia). kcontreras@husi.org.co
Luis Orlando Puentes-Puentes
Médico ginecooncólogo, Servicio de Ginecología y Obstetricia, Hospital Universitario San Ignacio, Bogotá (Colombia).
Jorge Luis Rodríguez-Sarmiento
Médico patólogo, Departamento de Patología, Hospital Universitario San Ignacio, Bogotá (Colombia).
Samuel Morales-Naranjo
Médico patólogo, Departamento de Patología, Hospital Universitario San Ignacio, Bogotá (Colombia).
Angélica María Parra-Linares
Médica residente de Ginecoobstetricia, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá (Colombia).
Juan David Botero-Bahamón
Médico residente de Medicina Interna, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá (Colombia).
References
Tempfer C, Horn LC, Ackermann S, Beckmann MW, Dittrich R, Einenkel J, et al. Gestational and non-gestational trophoblastic disease guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry No. 032/049, December 2015). Geburtshilfe Frauenheilkd. 2016;76:134-44. https://doi.org/10.1055/s-0041-111788
Horowitz NS, Goldstein DP, Berkowitz RS. Placental site trophoblastic tumors and epithelioid trophoblastic tumors: Biology, natural history, and treatment modalities. Gynecol Oncol. 2017;144:208-14. https://doi.org/10.1016/j.ygyno.2016.10.024
Brown J, Naumann RW, Seckl MJ SJ. 15 years of progress in gestational trophoblastic disease: Scoring, standardization, and salvage. Gynecol Oncol. 2017;144:200-7. https://doi.org/10.1016/j.ygyno.2016.08.330
Zhao J, Lv WG, Feng FZ, Wan XR, Liu JH, Yi XF, et al. Placental site trophoblastic tumor: A review of 108 cases and their implications for prognosis and treatment. Gynecol Oncol. 2016;142:102-8. https://doi.org/10.1016/j.ygyno.2016.05.006
Komatsuda A, Nakamoto Y, Asakura K, Yasuda T, Imai H, Miura AB. Case report: nephrotic syndrome associated with a total hydatidiform mole. Am J Med Sci. 1992;303:309-12. https://doi.org/10.1097/00000441-199205000-00007
Alvarez L, Ortega E, Rocamora N, Tormo A, Gil CM, Trigueros MRF. An unusual cause of nephrotic syndrome and hypertension in a young woman. Nephrol Dial Transplant. 2002;17:2026-9. https://doi.org/10.1093/ndt/17.11.2026
Teh HS, Halim AG, Soehardy Z, Fauzi AR KC. Molar pregnancy and glomerulonephritis. Med J Malaysa. 2006;61:361-2.
Altiparmark MR, Pamuk ON, Pamuk GE, Ozbay G. Membranous glomer ulonephritis in a patient with choriocarcinoma: Case report. South Med J. 2003;96:198-200. https://doi.org/10.1097/01.SMJ.0000051270.27624.48
Geun Han B, Hye Kim M, Ho Karl F, Hong SW, Choi SO. A case of membranoproliferative glomerulonephritis associated with a hydatidiform mole. Yonsei Med J. 2000;41:407-10. https://doi.org/10.3349/ymj.2000.41.3.407
Mazzucco G, Colla L, Monga G. Kidney involvement in a patient affected by placental site trophoblastic tumor. Am J Kidney Dis. 2011;57:516-20. https://doi.org/10.1053/j.ajkd.2010.11.019
Xiao C, Zhao J, Li M, Zhao D, Xiang Y. Lupus nephritis associated with placental site trophoblastic tumor: A case report and review of the literature. Gynecol Oncol Reports. 2014;9:26-8. https://doi.org/10.1016/j.gynor.2014.05.003
Yang JW, Choi SO, Kim BR, Kim YS, Yoo JM, Eom MS, et al. Nephrotic syndrome associated with invasive mole: A case report. Nephrol Dial Transplant. 2010;25:2023-6. https://doi.org/10.1093/ndt/gfq148
Batra V, Kalra OP, Mathur P, Kavita, Dev G. Membranous glomerulopathy associated with placental site trophoblastic tumour: A case report. Nephrol Dial Transplant. 2007;22:1766-8. https://doi.org/10.1093/ndt/gfl786
Feehally J, Floege J, Tonelli M JR. Comprehensive Clinical Nephrology. 6 ed. Elsevier; 2019. p. 184-89.
Blom K, Odutayo A, Bramham K, Hladunewich A. Pregnancy and glomerular disease. Clin J Am Soc Nephrol. 2017;12:1862-72. https://doi.org/10.2215/CJN.00130117
Young RH, Scully RE, McCluskey RT. A distinctive glomerular lesion complicating placental site trophoblastic tumor: Report of two cases. Hum Pathol. 1985;16:35-42. https://doi.org/10.1016/S0046-8177(85)80211-2
Fukunaga M, Ushigome S. Metastasizing placental site trophoblastic tumor. An immunohistochemical and flow cytometric study of two cases. Am J Surg Pathol. 1993;17:1003-10. https://doi.org/10.1097/00000478-199310000-00005
Denny LA, Dehaeck K, Nevin J, Soeters R, van Wijk AL, Megevand E, et al. Placental site trophoblastic tumor: Three case reports and literature review. Gynecol Oncol. 1995;59:300-3. https://doi.org/10.1006/gyno.1995.0026
Mohammadjafari R, Abedi P, Belady S, Hamidehkho T, Razi T. A case of nephrotic syndrome associated with hydatiform mole. Rare Tumors. 2010; 2:174-5. https://doi.org/10.4081/rt.2010.e61
Lien YH, Lain LW. Pathogenesis, diagnosis and management of paraneoplastic glomerulonephritis. Nat Rev Nephrol. 2011;7:85-95. https://doi.org/10.1038/nrneph.2010.171
Bacchetta J, Juillard L, Cochat P. Paraneoplastic glomerular diseases and malignancies. Crit Rev Oncol Hematol. 2009;70:39-58. https://doi.org/10.1016/j.critrevonc.2008.08.003
Viau M, Renaud MC, Grégoire J, Sebastianelli A, Plante M. Paraneoplasic syndromes associated with gynecological cancers: A systematic review. Ginecol Oncol. 2017;146:662-71. https://doi.org/10.1016/j.ygyno.2017.06.025
Rodrigues JC, Haas M, Reich HN. CJASN Glomerular Disease Education Series : IgA Nephropathy. Clin J Am Soc Nephrol. 2017;12:1-10. https://doi.org/10.2215/CJN.07420716
Piccoli GB, Daidola F, Attini R et al. Kidney biopsy in pregnancy: Evidence for counselling? A systemic narrative review. BJOG. 2013;120:412-27. https://doi.org/10.1111/1471-0528.12111
How to Cite
Downloads
Downloads
Published
Issue
Section
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
