A case report and literature review of steroid cell tumours, not otherwise specified
DOI:
https://doi.org/10.18597/rcog.308Keywords:
ovarian steroid cell tumour, ovarian neoplasia, virilisationAbstract
Introduction: ovarian steroid cell tumours, not otherwise specified (NOS), is a not very frequently occurring ovarian sex chord neoplasia. It is characterised by becoming presented at any age and producing different endocrine manifestations due to the hormonal influx of patients suffering it. It has 50% potential malignancy.
Objective: reporting the case of a 50 yearold patient diagnosed by histology and immunohistochemistry studies as having malign steroid cell tumour NOS. Carrying out a literature review for the clinical presentation, genetics, diagnosis and treatment of this not very frequently occurring type of neoplasia.
Methodology: an electronic search of the literature we carried out using the following databases: MEDLINE, Embase, HINARI, Ovid, SciELO y BIREME. The search was limited to include the most outstanding original research and review articles from 1987 to 2008.
Results: 74 pertinent case reports were found. Clinical manifestations were variable and nonspecific according to the production of hormones such as testosterone, oestrogen or progestagen. Abdominal pain, severe ascites and Cushing’s syndrome were also presented. Differential diagnosis included other steroid tumours such as luteinizing thecoma, luteoma during pregnancy, primary clear cell carcinoma, metastatic renal cell carcinoma and hilar and non-hilar Leydig cell tumours. Treatment is by surgery accompanied by gonadotropin-releasing hormone (GnRH) agonist treatment.
Conclusion: steroid cell tumours occur infrequently and are associated with endocrine syndromes. Their management has not been standardised and must be individualised according to tumour histology, surgical state and the desire to become fertile. Studies are required for making advances in gaining knowledge about these tumours.
Author Biographies
Javier Andrés Ramírez
Óscar Suescún
María Cristina Palomino
References
Guppy AE, Nathan PD, Rustin GJ. Epithelial ovarian cancer: a review of current management. Clin Oncol 2005;17:399-411.
Stephens JW, Fielding A, Verdaguer R, Freites O. A steroid-cell tumor of the ovary resulting in massive androgen excess early in the gonadol steroidogenic pathway. Gynecol Endocrinol 2008;24:151-3.
Hayes MC, Scully RE. Ovarian steroid cell tumors (not otherwise specified). A clinicopathological analysis of 63 cases. Am J Surg Pathol 1987;11:835-45.
Wang PH, Chao HT, Lee RC, Lai CR, Lee WL, Kwok CF, et al. Steroid cell tumors of the ovary: clinical, ultrasonic, and MRI diagnosis-case report. Eur J Radiol 1998;26:269-73.
Kim YT, Kim SW, Yoon BS, Kim SH, Kim JH, Kim JW, et al. Ovarian steroid cell tumor causing virilization and ascites. Yonsei Med J 2007;48:142-6.
Pathology and genetics of tumours of the breast and female genital organs. En: Tavassoli F, Devilee P, editors. World Health Organization Classification of Tumours. Tumours of the breast and female genital organs 2003. Chapter 2. p.160-61.
Lin CJ, Jorge AA, Latronico AC, Marui S, Fragoso MC, Martin RM, et al. Origin of an ovarian steroid cell tumor causing isosexual pseudoprecocious puberty demonstrated by the expression of adrenal steroidogenic enzymes and adrenocorticotropin receptor. J Clin Endocrinol Metab 1999;85:1211-4.
Haji AG, Sharma S, Babu M, Vijaykumar D, Chitrathara K. Androgen secreting steroid cell tumor of the ovary in a young lactating women with acute onset of severe hyperandrogenism: a case report and review of literature. J Med Case Reports 2007;1:182.
Deavers MT, Malpica A, Ordonez NG, Silva EG. Ovarian steroid cell tumors: an immunohistochemical study including a comparison of calretinin with inhibin. Int J Gynecol Pathol 2003;22:162-7.
Vulink AJ, Vermes I, Kuijper P, ten Cate LN, Schutter EM. Steroid cell tumor not otherwise specified during pregnancy: a case report in a pregnant patient. Eur J Obstet Gynecol Reprod Biol 2004;112:221-7.
Roth LM. Recent advances in the pathology of ovarian sex cord-stromal tumors. Int J Gynecol Pathol 2006;25:199-215.
Geisler JP, Geisler HE, Manahan KJ, Miller GA, Linnemeier G. Genetics of steroid cell tumors of the ovary. CME J Gynecol Oncol 2003;8:167-9.
Reedy MB, Richards WE, Ueland F, Uy K, Lee EY, Bryant C, et al. Ovariansteroid tumors,not otherwise specified: a case report and literature review. Gynecol Oncol 1999;75:293-7.
Liu AX, Sun J, Shao WQ, Jin HM, Song WQ. Steroid cell tumors, not otherwise specified (NOS), in an accessory ovary: a case report and literature review. Gynecol Oncol 2005;97:260-2.
Vadillo-Buenfil M, Ramírez-Mendoza P, Cárdenas-Cornejo I, González-Bárcena D. Tumor ovárico de células esteroideas: informe de caso. Ginecol Obstet Mex 2000;68:259-65.
Luque-Cuba E, García-Ramos F, Rechkemmer-Prieto A, Solis-Villanueva J, Rosas-Vargas L, Castillo-Sayan O, et al. Tumor de células esteroideas del ovario: reporte de caso. Rev Med Her 2005;16:80-6.
Wang PH, Chao HT, Lee WL. Use of a long-acting gonadotropin-releasing hormone agonist for treatment of steroid cell tumors of the ovary. Fertil Steril 1998;69:353-5.
Mironov S, Akin O, Pandit-Taskar N, Hann LE. Ovarian cancer. Radiol Clin North Am 2007;45:149-66.
Dowdy SC, O'Kane DJ, Keeney GL, Boyd J, Podratz KC. Telomerase activity in sex cord-stromal tumors of the ovary. Gynecol Oncol 2001;82:257-60.
Baker PM, Olive C. Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors: an update. Int J Gynecol Pathol 2004;24:39-55.
McCluggage WG, McKenna M, McBride HA. CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors. Int J Gynecol Pathol 2007;26:322-7.
Tanaka YO, Saida TS, Minami R, Yagi T, Tsunoda H, Yoshikawa H, et al. MR findings of ovarian tumors with hormonal activity, with emphasis on tumors other than sex cord-stromal tumors. Eur J Radiol 2007;62:317-27.
Brewer CA, Shevlin D. Encouraging response of an advanced steroid-cell tumor to GnRH agonist therapy. Obstet Gynecol 1998;92:661-3.
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