Neo-adjuvant chemotherapy as treatment for fertility preservation in patients with stage IB cervical cancer: Case presentation and review of the literature
DOI:
https://doi.org/10.18597/rcog.15Keywords:
Retroperitoneal, haematoma, vaginal hysterectomy, haemorrhageAbstract
Objective: To present the case of a patient with stage IB1 cervical cancer larger than 2 centimetres who received neo-adjuvant chemotherapy followed by laparoscopic radical cervicectomy and pelvic lymphadenectomy for fertility preservation; and to review the literature for case reports emphasizing obstetric and oncologic outcomes.
Materials and methods: Case presentation and search of the literature in Medline through PubMed of articles published in English, French and Spanish between January 2000 and August 2014 on the topic of neo-adjuvant chemotherapy and fertility preservation surgery in patients with stage IB cervical cancer.
Results: Overall, 12 relevant articles were selected totalling 55 patients. Over follow-up period ranging between 14 and 69 months there were 4 relapses and only one death attributable to the disease. Obstetric outcomes included 30 pregnancies, 24 births, 3 miscarriages, 1 ectopic pregnancy, and 2 on going pregnancies.
Conclusion: Neo-adjuvant chemotherapy followed by conservative, fertility preservation surgery may be an option for the management of selected patients with stage IB cervical cancer involving large tumours sizes, who wish to preserve their fertility.
Author Biographies
Mónica Isabel Vásquez-Arenas
Lina Echeverri-Álvarez
Gabriel Rendón-Pereira
René Pareja-Franco
References
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012. Estimated cancer incidence, mortality and prevalence in 2012 Worldwide France: International Agency for Research on Cancer; 2012 [visitado 2015 May 18]. Disponible en: http://globocan.iarc.fr.
Watson M, Saraiya M, Benard V, Coughlin SS, Flowers L, Cokkinides V, et al. Burden of cervical cancer in the United States, 1998-2003. Cancer. 2008;113(10 Suppl):2855-64.
Kardakis S. Fertility-preserving surgery in patients with early stage cervical carcinoma. ISRN Oncol. 2012;2012:817065.
National Comprehensive Cancer Network. The National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology. Cervical Cancer. CERV-2-3 [visitado 2015 May 22]. Disponible en: http://www.nccn.org/professionals
Andrade JM, Marana HR, Mangieri LF, Matthes AC, Cunha SP, Bighetti S. Successful preservation of fertility subsequent to a complete pathologic response of a squamous cell carcinoma of the uterine cervix treated with primary systemic chemotherapy. Gynecol Oncol. 2000;77:213-5.
Kobayashi Y, Akiyama F, Hasumi K. A case of successful pregnancy after treatment of invasive cervical cancer with systemic chemotherapy and conization. Gynecol Oncol. 2006;100:213-5.
Plante M, Lau S, Brydon L, Swenerton K, LeBlanc R, Roy M. Neoadjuvant chemotherapy followed by vaginal radical trachelectomy in bulky stage IB1 cervical cancer: case report. Gynecol Oncol. 2006;101:367-70.
Wang D, Yang J, Shen K, Xiang Y. Neoadjuvant chemotherapy followed by fertility-sparing surgery for women with stage IB1 cervical cancer. J Gynecol Oncol. 2013;24:287-90.
Kim HS, Sardi JE, Katsumata N, Ryu HS, Nam JH, Chung HH, et al. Efficacy of neoadjuvant chemotherapy in patients with FIGO stage IB1 to IIA cervical cancer: An international collaborative meta-analysis. Eur J Surg Oncol. 2013;39:115-24.
Maneo A, Chiari S, Bonazzi C, Mangioni C. Neoadjuvant chemotherapy and conservative surgery for stage IB1 cervical cancer. Gynecol Oncol. 2008;111:438-43.
Marchiole P, Tigaud JD, Costantini S, Mammoliti S, Buenerd A, Moran E, et al. Neoadjuvant chemotherapy and vaginal radical trachelectomy for fertility-sparing treatment in women affected by cervical cancer (FIGO stage IB-IIA1). Gynecol Oncol. 2011;122:484-90.
Liu H, Peng ZL, Lou JY, Ping W. Pregnancy after neoadjuvant chemotherapy followed by pelvic lymphadenectomy and radical trachelectomy in bulky stage IB1 cervical cancer: a case report. Aust N Z J Obstet Gynaecol. 2008;48:517-8.
Singh P, Nicklin J, Hassall T. Neoadjuvant chemotherapy followed by radical vaginal trachelectomy and adjuvant chemotherapy for clear cell cancer of the cervix: a feasible approach and review. Int J Gynecol Cancer. 2011;21:137-40.
Hamed AH, Shepard MK, Maglinte DD, Ding S, Del Priore G. Neoadjuvant chemotherapy followed by simultaneous robotic radical trachelectomy and reversal of tubal sterilization in stage IB2 cervical cancer. JSLS. 2012;16:650-3.
Palaia I, Musella A, Loprete E, Achilli C, Perniola G, Panici PB. Neoadjuvant chemotherapy plus fertility-sparing surgery in locally advanced cervical cancer: case report. J Minim Invasive Gynecol. 2011;18:121-2.
Lanowska M, Mangler M, Speiser D, Bockholdt C, Schneider A, Kohler C, et al. Radical vaginal trachelectomy after laparoscopic staging and neoadjuvant chemotherapy in women with early-stage cervical cancer over 2 cm: oncologic, fertility, and neonatal outcome in a series of 20 patients. Int J Gynecol Cancer. 2014;24:586-93.
Robova H, Halaska M, Pluta M, Skapa P, Strnad P, Lisy J, et al. The role of neoadjuvant chemotherapy and surgery in cervical cancer. Int J Gynecol Cancer. 2010;20:S42-6.
Landoni F, Parma G, Peiretti M, Zanagnolo V, Sideri M, Colombo N, et al. Chemo-conization in early cervical cancer. Gynecol Oncol. 2007;107:S125-6.
How to Cite
Downloads
Downloads
Published
Issue
Section
License
Copyright (c) 2015 Revista Colombiana de Obstetricia y Ginecología
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |
