Prolactina en pacientes con trastornos endocrinos y de fertilidad


  • Ariel Iván Ruiz
  • Catalina Acevedo
  • William Onatra H.



La prolactina (PRL) es una hormona polipeptídica secretpor los lactotropos de la hipófisis.

Biografía del autor/a

Ariel Iván Ruiz

lnstructor Asistente.

Catalina Acevedo

R3 de Ginecología y Obslelricia.

William Onatra H.

Profesor Asistente. Departamento de Obstetricia y Ginecología. Universidad Nacional de Colombia. lnstituto Malerno lnfantil Bogotá.

Referencias bibliográficas

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KEIFER. K.A. ; MALARKEY, W.B. Size heterogeneity of human prolactin in CSF and serum: experimental conditions that alter gel filtration patterns. J Clin Endocrinol Metab 46: 119. 1978.

YEN, S .S.C. Prolactin in human reproduction in YEN SSC. JAFFE RB, Reproductive Endocrinology. Physiology, Pathophysiology and Clinical management. 2 Ed. WB. Saunders Ca. Philadelphia 1986, Pp 237.

FARKOUH. N.H.; PACKER, M.G.; FRANTZ, A.G. Large Molecular PRL with reduced receptor activity in human serum: High proportion in basal state and reduced after TRH. J Clin Endocrinol Metab 48: 1026, 1979.

ARCHER. D.F. Fisiología de la prolactina. Clin Obstet Ginecol 2: 321, 1980.

TYSON, J.E.; HWANG, P.; GUYDA, H. et aL Studies of prolactin secretion in human pregnancy, Am J Obstet Gynecol 113: 14, 1972.

BEN-JONATHAN, N. Dopamine: a prolactin-inhibiting homone, Endocrin Revíer 6: 564, 1985.

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JOSIMOVICH, J.B. ; ARCHER, D.F. The rol of lactogenic homones in the woman and the fetus . Am J Obstet Gynecol 129: 777, 1977.

MASLAR, LA.; RIDDICK, D.H. Prolactin Production by human endometrium during the normal menstrual cicle. Am J Obstet Gynecol 135: 751 , 1979.

HAMMOND, C.B. Prolactin syndromes. Clinical advances in reproductive endocrinology and infertility. The American Fertility Society and Serono Symposia. USA 50. 1983.

KORDON, C.; BLAKE. C.A.; TERKEL. J . et aL Participation of serotonincontaining neurons in the suckling-induced rise in plasma prolactin leves in lactating rats. Neuroendocrinology 13: 213. 1974.

WEST, B.; DANNIES, P .S . Effects of estradiol on prolactin production and dihydroergoc riptine- induced inhibition and prolactin production by primary cultures of rat pituitary cells. Endocrinology 106: 1108. 1980.

PRIOR, J .C. ; COX, T.A. ; FAIRHOLM, D. et aL Testosterone related exacerbation of a prolactin producing macroadenoma: possible role for estrogen. J Clin Endocrinol Metab 64: 391, 1987.

MALARKEY, W.B. Prolactin and the diagnosis of pituitary tumors. Ann Rev Med 30: 249, 1979.

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BARBIERI, R.L.; RYAN , K.J . Bromocriptine: endocrine pharmacology and therapeutic applications. Fertil Steril 39: 727, 1983.

McCARTY, K.S.; DOBSON 11 CE. Patologia Hipofisiaria asociada con anormalidades de la secreción de PRL. Clin Obstet Gynecol 2: 365, 1980.

WIEBE, R.H. Valoración endocrina de hiperprolactinemia. Clin Obstet Gynecol 2: 347, 1980.

MULCHAHEY, JJ.; JAFFE, R.B. Detection of a potential progenitor cell in the human fetal pituitary that secretes both growth hormone and prolactin. J Clin Endocrinol Metab 66: 24, 1987.

LUNDBERG, P.O.; OSTERDAM, P.O.; WIDEL, L. Serum prolactin in patients with hypothalamus and pituitary disorders. J Neurosurg 55: 194, 1981.

THOMAS, R. ; REID, L. Thyroid disease and reproductive dysfunction: a review. Obstet Gynecol 70: 789, 1987.

GRUBB, M.R. ; CHAKERES, D.; MALARKEY, W.B. Patients with primary hypothytoidism presenting as prolactinomas. Am J Med 83: 765, 1987.

ROTH,J.; GRUNFELD, C. Mechanism of action of peptide hormones and catecholamines. In Wilson JO, Foster DW (Eds): Williams Textbook of Endocrinology. Philadelphia WB Saunders Pp 76, 1985.

FRADKIN, J.E.; EASTMAN, R.C.; LESNIAK, M.A. et al.Specificity Spillover at the hormone receptor- Exploring its role in human disease. New Engl J Med 320: 640, 1989.

QUIGLEY, M.M.; HANEY, A.F. Valoración de hiperprolactinemia, Perfiles Clínicos. Clin Obstet Gynecol2: 333,1980.

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SHEARMAN, R.P. Secondary amenorrhoea. In SHEARMAN RP Clinical Reproductive Endocrinology. Churchill Livingstone. Endinburgh Pp 493, 1985.

GUITELMAN, A. Use of bromocriptine as a diagnostic and therapeutic tool in hyperprolactinemic states. Recent advances in infertility research: developments in reproductive endocrinology. Alan R Liss lnc. New York Pp 255, 1982.

HARDY, M,; O'CONNELL, J .; GILBERTSON, N. et al. Precocious puberty associated with hyperprolactinemia in a male patient. J Pediatrics 113: 508, 1988.

HIGUCHI, K. ; NAWATA, H.; MAKI, T. et al. Prolactin has a direct effect on adrenal androgen secretion. J Clin Endocrinol Metab 59: 714, 1984.

VAUGHN, T.C.; HAMMOND, C.B. Tumores hipofisiarios productores de prolactina: terapéutica médica. Clin Obstet Gynecol 2 : 403, 1980.

MacLEDD. R.M.; LEHMEYER, J .E. Supression of pituitary tumor growth and function by ergot alkaloids. Cancer Res 33: 849. 1973.

GOLDMAN, M.; STEINBERGER, GANTI, S. Hyperprolactinemia with prolonged amenorrhea reversed with bromocriptine in a menopausal woman Am J Obstet Gynecol 158: 117. 1988.

SPARK, R.F.; BAKER, R.; BIENFANG, D.C. et al. Bromocriptine reduces pituitary tumor size and hypersecretion : requiem for pituitary surgery. JAMA 247: 3 11, 1982.

GEORGE, S.R.; BURROW, G.N. ; ZINMAN, B. et al. Regression of pituitary tumors a possible effect of broergocryptine. Am J Med 66: 697, 1979.

MOLITCH, M.E.; ELTON, R.L.; BLACKWELL, R.E. et al. Bromocriptine as primary therapy for prolacting macroadenomas: results a prospective multicenter study. J Clin Endocrinol Metab 60: 698, 1985.

VELENTZAS, C.; CARRAS, D.; VASSILOUTHIS, J. Regression of pituitary prolactinoma with bromocriptine asministration JAMA 245: 1149, 1981.

JOHNSTON, D.G.; PRESCOTT, R.W.G.; KENDALL, T.P. et al. Hyperprolactinemia. Long-term effects of bromocriptine. Am J Med 2: 700, 1983.

WASS, J.A.H.; WILLIAMS, J .; CHARLESWORTH, M. et al. Bromocriptine management of large pituitary tumors. Br Med J 284: 1908, 1982.

MORIONDO, P.; TRVAGLINI, P.; NISSIM, M. et al. Bromocriptine treatment of microprolactinomas: evidence of stable prolactin decrease after drug withdrawal. J Clin Endocrinol Metab 60: 764, 1985.

McGREOR A.M.; SCANLOM, M.F.; HALL, R. et al. Bromocriptine on pituitary tumor size. Br Med J 2 : 700, 1979.

THORNER, M.O.; MARTIN, W.H.; ROGOL,A.D. et al. Rapid regression of pituitary prolactinomas during bromocriptine treatment. J Clin Endocrin Metab 51: 436, 1980.

THORNER, M.O.; PERRYMAN, R. ; ROGOL, A.D. et al. Rapid Changes of prolactinomas volumen after withdrawal and reinstitution of bromocriptine Journal Clinic Endocrinologic and Metabolism 53: 480, 1981.

KENAN, P.D. Accesos Quirúrgicos para tumores hipofisiarios Clin Obstet Ginecol 2: 413, 1980.

DOMINGUE, J.N .; RICHMOND, I.L.; WILSON, C.B. Results of surgery in 114 patients with prolactin secreting pituitary adenomas. Am J Obstet Gynecol 137: 102, 1980.

POST, K. D.; DILLER, B.J. ADELMAN, L.S. et al. Selective transphenoidal adenomectomy in women with galactorrea amenorrhea JAMA 242: 158, 1979.

SCHLENCHTE, J .; VANGILDER, J.; SHERMAN, B. Predictors of the outcome of transphenoidal surgery for prolactin- secreting prolactin-secreting pituitary adenoma. J Clin endocrinol Metab 52: 785, 1981.

SERRI, 0 .; RASIO, E .; BEAUREGARD, H. et al. Recurrence of hyperprolactinemia after selective transphenoidal adenomectomy in women with prolactinoma. N Engl J Med 209: 280, 1983.

TUCKER, G.; LANKFORD, H.V.; GARDNER, D.F. et al. Persistent defect in regulation of prolactin secretion after successful pituitary-tumor renmoval in women with galactorrhea-amenorrhea syndrome. J Clin Endocrinol Metab 51: 968, 1980.

NOELL, K.T. Tumores hipofisiarios productores de prolactina y de otras hormonas: Terapéutica por radiación. Clin Obstet Gynecol 2: 443, 1980.

MARSHALL, J.R. Embarazo en pacientes con tumores hipofisiarios productores de prolactina. Clin Obstet Gynecol 2:457, 1980.

GRIFFITH, R.W. ; TURKALY,I.; BRAUNN, P. Outocome of pregnancy in mother given bromocriptine. Br J Clin Pharmacol 5: 227. 1978.

Cómo citar

Ruiz AI, Acevedo C, Onatra H. W. Prolactina en pacientes con trastornos endocrinos y de fertilidad. Rev. colomb. obstet. ginecol. [Internet]. 27 de marzo de 1991 [citado 12 de julio de 2024];42(1):25-33. Disponible en:


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