Aletos HLA DQ alfa maternos, pérdida recurrente del embarazo y síndrome de anticuerpos antifosfolípidos

Autores/as

  • A. E. Beer Escuela Médica de Chicago
  • J. Y. Kwak Escuela Médica de Chicago
  • J. Cubillos
  • P. Sandoval
  • J. C. Mendoza Colegio Mayor del Rosario
  • F. Espinel

DOI:

https://doi.org/10.18597/rcog.3003

Palabras clave:

Antiphospholipids antibodies, RSA recurrent spontaneous abortion, HLA DQ alfa 4.1

Resumen

Anticuerpos antifosfo lípidos (AAP) son documentados en muchos casos de aborto recurrente espontáneo (ARE) de causa inexplicada. Los anticuerpos antifosfolípidos interfieren con la producción de prostaciclina causando un incremento en la agregación plaquetaria, vasoconstricción, trombosis e infartos placentarios (5-6).

Biografía del autor/a

A. E. Beer, Escuela Médica de Chicago

Profesor en Microbiología e Inmunología. Profesor en Obstetricia y Ginecología, Universidad de Ciencias de la Salud. Escuela Médica de Chicago.

J. Y. Kwak, Escuela Médica de Chicago

Universidad de Ciencias de la Salud. Escuela Médica de Chicago.

J. Cubillos

Coordinadora Laboratorio. Unidad Inmunología y Genética
HIULYS.

P. Sandoval

Residente III Año Ginecología y Obstetricia HIULYS .

J. C. Mendoza, Colegio Mayor del Rosario

Instructor Asistente. Colegio Mayor del Rosario.

F. Espinel

Coordinador Unidad Inmunobiología y Genética HIULYS.

Referencias bibliográficas

Cowchock FS., Smith JB. and Glocial B. Antibodies lo phospholipids and nuclear antigens in patients with repeated abonions. A m. J. Obstet. Gynecol. 1986; 15 5: 1002- 1010.

Unander AM., Norberg R., Hahn L. and Arfors L. Anticardiolipin antibodies and complemenl in ninety nine women with habitual abortion. A m. J. Obstet. Gynecol. 1987; 156: 114-119.

Barbui T., Radici. , Cortelazzo S., Rossi E., Calli M. , Finazzi G. and Parzzini F. Antiphospholipid antibodies in early repeated abortions: a case controlled study. Fertil. Steril. 1988; 50: 589-592.

Kwak J .. Gilman-Sachs A., Beaman K. and Beer AE. Autoantibodies in women wilh primary recurrent spontaneous abonion of unknown etiology. J. Reprod. lnmunol. 1992; 22: 15-31.

De WolfF., Carreras LO., Moerman R., Van AsscheA. and RenaerM. (1982). Decidual vasculopathy and extensive placenta! infarcti on in a palient with repeated lhromboembolic accidents, recurrent fetall oss and lupus anticoagul ant. Am. J. Obstel. Gynecol. 1982; 142: 829-834.

Ferro D., Saliola M., Quintarelli C.. Basili S., Grandilli A. and Bonavita MS. Methods for de tecting lupus anticoagulants and their relation LO thrombosis and mi scarriage in patients with systemic lupuserythematosus. J. Clin. Pathol. 1992; 45: 332-338.

Session A. and Horowitz A. Differentiation related differences in the lasma membrane phospholipid asymmetry of mytogenic and fibrogenic cells. Biochem Biophys Acta. 1983; 728: 103-111.

Hasegawa I., Takakuwa S. and Kanazawa K. Cy totox ic antibody against trophoblast and lymphocytes present in pregnancy with intrauteri ne growth retardation and its relation to anti- phospholipid antibody. J. Reprod . lmmunol. 1990; 17: 127-139.

Kwak J., Gilmn-Sachs A., Beaman K. and Beer AE. Reproductive ou tcome in women with recurren! spontaneous abortions of

alloimmune and autoimmune etiologies; pre vs post conception Lreatment. Am. J. Obstet. Gynecol. 1992; 166: 1975-1987.

Molkentin J., Baxter-Lowe LA. Detectionof 14 HLADQB1 al le les by oli gotyping. Human. lmmunol. 3 1: 114-122.

Kwak J .. Barini R., Gilman-Sachs A., Be aman K. and Beer AE. Down regulation of maternal au toimmune response may determine pregnancy outcome. Am. J. Reprod. Immunol. 1992: 27: 24.

Kwak J .. Barini R., Gilman-Sachs A., Beaman K. and Beer AE. Down regulation of maternal antiphospholipid antibodies during early pregnancy and pregnancy ou tcome. Society of Ginecologic lnvesligation 40th Annualmeeting 1993 ; 107.

Beer AE., Zhu X., Semprini AE. and Quebbeman JF. Pregnancy outcome in human couples wit h idiopathi c recurrent abortions: the role of female serum mixed lymphocyte culture blocking factors, potentiating factors and local uterine immunity before and after paternalleukocyte immunization. In Beer AE., Zhu X., Semprini AE. and Quebbeman JF. (eds). Immun o logical Approaches to Contraception and Promotion of Fertility, pp. Pages. Plenum Publishing.l986.

Smith J. and Cowchock F. lmmunological studies in recurrent spontan eus aborti on: effects of immunization of women with paternal mononuclea r cells on lymphocytotoxic amn mixed lymphocytercaction blocking antibodies and correlation wi th sharing of HLA and pregnancy outcome. J. Reprod. lmmunol. 1988; 14: 99.

Zuricr. R.B. Sytemic lupus erythematosus and pregnancy. Clin . Rheum. Dis. 1975 ; 1: 613.

Kwak J ., Ober C., Barini R. and Beer AE. Maternal autoimmune abnonnal ities and fetal HLA-DQAl alleles in women with recurrent spontaneous abortion . Society for Gynecologi c In vestigation . San Antonio 992; 363.

Nclson J .. Hughes KA .. Smith A. , Nisperos BB., Branchaud AM. and Han se n JA. Maternal-fetal disparity in HLA c lass 11 alloantigens and the pregnancy induced amelioration and rheumatoid arthritis. N. England. J. Med. 1993; 329: 446-47 J.

Gleicher N., Harlow L. and Zilberstein M. Regulatory effect of antiphospholipid antibodies on signal transd uction: A possibl e model for autoantibody induced reproduclive failure. A m. J . Obste l. Gynecol. 1992; 167: 637-642.

Hand werger S., Barret J., Markoff BF., Zeitler P., Cwikel B. and Sicgel M. Stimulation of human placenta! lactogen release by araquidonic asc id. Mol. Pharmacol. 198 1; 20:609-613.

Cómo citar

1.
Beer AE, Kwak JY, Cubillos J, Sandoval P, Mendoza JC, Espinel F. Aletos HLA DQ alfa maternos, pérdida recurrente del embarazo y síndrome de anticuerpos antifosfolípidos. Rev. colomb. obstet. ginecol. [Internet]. 19 de diciembre de 2023 [citado 29 de marzo de 2024];45(2):123-6. Disponible en: https://revista.fecolsog.org/index.php/rcog/article/view/3003

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2023-12-19

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