Acción del Acetato de 6 alfa-metil 17 alfa hidroxy progesterona sobre las Contracciones de Braxton-Hicks en el Embarazo Avanzado y algunos estudios sobre su Metabolismo

Fernando Del Corral, Robert E. Stempfel, E. C. Hamhlen, N. Durhan

Resumen


La mayor parte de los estudios clínicos practicados con la Progesterona y sus esteroides derivados e híbridos, han estado enfocados la mayor parte de las veces sobre la acción en el endometrio y sus diversas causas de hemorragia.

 


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Referencias


ALLEN, W. M. and CORNER, G. W.: Physiology of corpus luteum. III. Normal growth and implantation of embryos after very early ablation of the ovaries, under the influence of extracts of the corpus luteum, Am. J. Physiol. 88:340-346 (March) 1929.

BENGTSSON L. P.: The effect of pitocin on the placenta, Am. J. Obst. & Gynec. 74:518-520 (Sep.) 1957.

BONGIOVANNI, A. M. and EBERLEIN, W. R.: Critical analysis of methods for measurement of pregnane-3-alpha, 17-alpha, 20-alpha-triol in human urine, Analytical Chem. 30:388-393, 1958.

BONGIOVANNI, A. M.; EBERLEIN, W. R., and CARA. J.: Studies on the metabolism of adrenal steroids in the adrenogenital syndrome,J. Clin. Endocrinol & Metab. 14:409-422 (April) 1954.

BROUHA, L. and SIMMONNET, H.: Action du liquide folliculaire sur la contractilite uterine, Comp. Rend. Soc. de Biol. 96:96-97 (Jan.) 1927.

CORNER, G. W.: Cyclic variation in uterine and tubal contraction waves, Am. J. Anat. 32:345-351 (Nov.) 1923.

CSAPO, A.: Actomyosin formation by estrogen action. Am. J. Physiol. 162 406-410. (Aug.) 1950.

CSAPO, A.: Progesterone “block”, Am. J. Ant. 98:273-291 (March) 1956.

CSAPO, A.: The relation of threshold to the K gradient in the myometrium, J. Physiol. 133:145-158 (July 27) 1956.

DAVIS, M. E. and PLOTZ, E. J.: Hormones in human reproduction. II. Further investigation of steroid metabolism in human pregnancy. Am. J. Obst. & Gynec. 76:939-954 (Nov.) 1958.

ENGELHARDT, W. A. and LJUBIMOWA, M. N.: Myosine and adenosinetri-phosphatase, Nature. 144:668-669 (Oct. 14) 1939.

FALLS, F. H.; LACKNER, J. B., and KRONH, L.: Effect of progestin and estrogenic substance on human uterine contraction. J. A. M. A. 106:271-275 (Jan. 25) 1936.

GLENN, E. M., and NELSON, D. H.: Chemical method for the determination of 17-hidroxy-corticosteroids and 17-ketosteroid in urine following hydrolysis with beta-glucuronidase, J. Clin. Endocrinol. & Metab. 13:911-921 (Aug.) 1953.

HAMBLEN, B. C. et al.: Unpublished data.

HEUSSER, H.; ENGEL, CH. R.; HERZIG, P. The. and PLATTNER, PI. A.: Uber steroide und sexualhormone. Uber 17-methyl-progesterone A, ein hoch aktives gestagen, und seine bereitung aús 21-bzw. 17-halogen-pregnenolon. Helv. Chim. Acta. 33:2229-2236, 1950.

HOLTORFF, A. F. and KOCH, F. C.: The colorimetric estimation of 17-ketosteroids and their application to urine extracts. J. Biol. Chem. 135:377-392 (Sep.) 1940.

HORVATH, B.: Ovarian hormones and the ionic balance of uterine muscle, Proc. Nat. Acad. Science. 40:515-521, 1954.

KEYE, J. D.: Periodic variations in spontaneous contractions of uterine muscle, in relation to the oestrous cycle and early pregnancy, Bull. Johns Hopkins Hospital 34: 60-63 (Feb.) 1923.

KNAUS, H.: Zur frage der standardisation des corpus luteum-extractes. Arch. f. Exp. Path, u Pharmakol. 151: 371-380 (June-July) 1930.

MAKEPEASE, A. W.; CORNER, G. W., and ALLEN, W. M.: The effect of progestin on the in vitro response of the rabbit’s uterus to pituitrin, Am. J. Physiol. 115: 376-385 (April) 1936.

MANZI, L.: Azione inibente degli estratti di corpo lúteo sul travaglio provoca to dagli estratti di lobo posteriore dell, ipofisi, nelle varie epoche della gravidanza, ricerche sperimentali. Arch, di Ostet. e Ginec. 19:220-232 (May) 1932.

MARDONES, E.; IGLESIAS, R., and LIPSCHUTZ, A.: Physiological action of 19-norprogesterone in the guinea pig, Poc. Soc. Exper. Biol. & Med. 86: 451-413 (July) 1914.

MEYSTRE, CH.; TSCHOPP, E., and WETTSTEIN, A.: Uber steroide. Uber 11-dehydroprogesterone, das wirksamste gestagen. Helv. Chim. Acta 31:1463-1469, 1948.

MURPHY, D. P.: Measurements of uterine contractions in late pregnancy. A study of five patients with the Lorand tocograph. Surg. Gynec. & Obst. 70:129-135 (Feb. 1940).

MURPHY, D. P.: Uterine Contractility in Pregnancy. A Study of the Contractions of Pregnancy and Labor Under Normal and Experimental Conditions, J. B. Lippicott Co., Publisher, Philadelphia, 1947.

OLSEN, A. C.; SALHANICK, H. A., and HISAW, F. L.: The inhibitory action of various steroids on the Hooker-Forbes assay for progesterone, Endocrinology. 51:519-523 (Dec.) 1952.

PARKES, A. S. and BELLERBY, C. W.: Studies on the internal secretions of the ovary. II. The effects of injections of the oestrus producing hormone during pregnancy, J. Physiol. 62:145-155 (Dec. 10) 1926.

PLOTZ, B. J. and DAVIS, M. E.: The excretion of neutral steroids in the urine of pregnant women following the administration of large dotes of progesterone, Acta Endocrinol. 21:259-267 (March) 1956.

REYNOLDS, S. R. M. and FRIEDMAN, M. H.: Studies on the uterus. III. Activity of the uterine fistula in unanesthetized rabbits following coitus and during pseudopregnancy, Am. J. Physiol. 94:696-704 (Sep.) 1930.

ROBSON, J. M. and SHARAF, A. A.: Effects of some water soluble steroids on the uterus, J. Endocrinol. 8:133-137 (April) 1952.

STEMPFEL, R. S.: Unpublished data.

STRAUB F. B.: “Actin’’ IN Studies from the Institute of Medical Chemistry, Univ. of Szeged, Hungary, ed. by A. Szent-Gyorgy, vol. II, 1942, pp. 3-15, S. Karger, Publisher, Basel and New York.

SZENT-GYORGY, A.: Studies on muscle. Acta Physiol. Scandinav. vol. 9, Supplementum XXV, Stockholm, 1945.

VENNING, E. H.: Adrenal function in pregnancy. Endocrinology 39: 203-220 (Sep.) 1946.

ZANDER, J.; FORBES, T. R.; VON MUNSTERMANN, A. M., and NEHER, R.: Delta 4-3 ketopregnane-20 alpha-01 and delta 4-3-ke-topregnene-20 beta ol, two naturally ocurring metabolites of progesterone. Isolation, identification, biologic activity and concentration in human tissues. J. Clin. Endocrinol. & Metab. 18:337-353 (April) 1958.

ZARROW, M. X. and NEHER, G. M.: Concentration of progestin in the serum of the rabbit during pregnancy, the puerperium and following castration. Endocrinology. 56:1-8 (Jan.) 1955.

ZONDEK, B. and ASCHHEIM, S.: Ovulation in der graviditat-ausgelost durch hypophysenvonderlappenhormon. Endokrinologie. 1: 10-22 (Jan.) 1928.


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