Aplicaciones en ginecología de los antagonistas de lh-rh

Autores/as

  • José Ignacio Madero
  • Óscar Eduardo Guerra
  • Gabriel Barbosa
  • Carlos Morán
  • Pilar Gaitán
  • Mabel Ávila
  • Jesús Alberto Ruiz

DOI:

https://doi.org/10.18597/rcog.746

Palabras clave:

LHRH, GnRH, Antagonistas de GnRH, Estimulación ovárica, gonadotropinas, tratamiento del cáncer, miomatosis uterina

Resumen

Las modificaciones a la LH-RH nativa produjeron la aparición de los análogos: agonistas cuyas aplicaciones en la medicina reproductiva han sido ampliamente estudiadas y los antagonistas de reciente estudio y aparición. Existen ciertas situaciones clínicas en las cuales lo que se necesita es una rápida supresión de la producción de las gonadotropinas endógenas, y por el efecto estimulador inicial del análogo no se logra. Los antagonistas causan una supresión inmediata de la producción de FSH y LH por un bloqueo competitivo de los receptores lo cual hace que su uso sea óptimo en los casos de inducción de ovulación mas técnicas de reproducción asistida. Otras de la indicaciones potenciales serían los casos en los que se requiere una supresión de la producción endógena de esteroides sexuales como el caso de la hiperplasia benigna de próstata, el cáncer de próstata y el cáncer de ovario, en los cuales ha demostrado una promisoria utilidad.

Biografía del autor/a

José Ignacio Madero

Director Científico Medifertil,MEDIFERTIL, Programa de Reproducción Asistida.Profesores Departamento de Ginecología y Obstetricia, Universidad Javeriana.

Óscar Eduardo Guerra

Profesores Departamento de Ginecología y Obstetricia, Universidad Javeriana.

Gabriel Barbosa

Profesores Departamento de Ginecología y Obstetricia, Universidad Javeriana.

Carlos Morán

Reproductive Biology and Endocrinology, Department of Obstetrics and Gynecology. The University of Alabama at Birmingham

Pilar Gaitán

MEDIFERTIL, Programa de Reproducción Asistida.Profesores Departamento de Ginecología y Obstetricia, Universidad Javeriana.

Mabel Ávila

MEDIFERTIL, Programa de Reproducción Asistida.Profesores Departamento de Ginecología y Obstetricia, Universidad Javeriana.

Jesús Alberto Ruiz

MEDIFERTIL, Programa de Reproducción Asistida.Profesores Departamento de Ginecología y Obstetricia, Universidad Javeriana.

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Cómo citar

1.
Madero JI, Guerra Óscar E, Barbosa G, Morán C, Gaitán P, Ávila M, et al. Aplicaciones en ginecología de los antagonistas de lh-rh. Rev. colomb. obstet. ginecol. [Internet]. 30 de marzo de 2001 [citado 28 de marzo de 2024];52(1):69-76. Disponible en: https://revista.fecolsog.org/index.php/rcog/article/view/746

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2001-03-30

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