Agentes farmacológicos que afectan al feto

Alberto Duarte Contreras, José G. Coronel Becerra, Luis F. Luzardo M.

Resumen


Oímos a uno de nuestros maestros en alguna oportunidad la siguiente máxima: "no olvidemos que el Obstetra es el pediatra de! feto" (1). Ello nos hizo reflexionar muy seriamente en los riesgos a que está expuesto el feto con el cúmulo inagotable de agentes farmacológicos que se administran a la madre, muchas veces de manera indiscriminada. Nos detendremos a estudiar únicamente aquellos factores que son de uso corriente en nuestro medio.


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Referencias


GONZALEZ-RAMOS, M. Curso internacional de Genética Médica dictado en Lima. Sept. 22 a 26, 1968.

CASTELAZO-AYALA, L. y DOMINGUEZ-RO-BLES, H. Factores físicos y farmacológicos que afectan al feto. Ginec. Obstet. Méx. 20: 425, 1965.

CHASSAGNE, P. Risques thérapeltiques chez la femme en ceinte. La Rev. du Prat. 7: 12, 1966.

CHASSAGNE, P. Précautions thérapeutiques chez la femme en ceinte. Press. Méd. Paris. 71: 1075, 1963.

USANDIZAGA, J. A. Debemos vacunar contra la poliomielitis a las embarazadas? Medicamenta. 374: 341, 1960.

COBRINIK, R. W. The effect of maternal narcotic addiction on the newborn. Review of literature and report of 22 cases. Pediatrics. 24: 228, 1959.

GOODFRIEND, M. J.; SHEY, I. A. and KLEIN, M. D. The effects of maternal narcotic addiction on the newborn. Am. J. Obst. and Gynec. 71 : 29. 1956.

APGAR, V. and BRODIE, B. B. Am. J. Obst. Gynec. 64: 1368, 1952.

ECKENHOFF, J. E.; HOFFMAN, G. L. and FUNDENBURG, L. W. N-allylnormorphine: an antagonist to neonatal narcosis producet by sedation of the parturient. Am. J. Obst. and Gynec. 65: 1269, 1953.

FRIEND, D. G. Farmacodinamla en el feto. Clin. Pharmacol. Ther. 4: 141, 1963.

DOREY, H. H. Médlcaments donnés durant la gestation et aprés la nalssance. Effets néfastes por le foetuc et le nouveau-né. L'Unlon Méd. du Canada. 93: 555, 1964.

VAN S. MAECK, J. and STRAUSFELD, K. Analgesia y anestesia en el parto prematuro. Clin. Obst. y Gin. 707, 1964.

GILLESPIE, L. Tabaquismo y peso bajo del recién nacido. Clin. Obst. y Gin. 658, 1964.

CORONEL, J. G.; BUSTAMANTE, G. y URI-BE-BOTERO, G. Prematuridad en nuestro medio. Rev. Col. Pediatría. 10: 275, 1968.

ZABRISKIC, J. R. Effect of cigaret smoking during pregnancy. Obst. and Gynec. 21: 405, 1963.

O'LANE, J. M. Some effects of maternal cigaret smoking. Obst. and Gynec. 22: 181,1963.

SIMPSON, W. J. Preliminary report of cigarrette smoking and the incidence of prematurity. Am. J. Obst. and Gynec. 73: 808, 1957.

BUDNICK, I.; LEIKIN, S. and HOECK, L. Effects on the newborn infant of the Reser-pine administered ante partum. J.A.M.A. 90 : 286, 1955.

BOGGS, T. R. Jr.; LUCINE, A. A. and NEEDLEMAN, H. L. Promethazine hydrochlorhide and neonatal bilirubin concentration. Jr. Pediatric. 67: 160, 1963.

SOBEL, D. Fetal damage due to E. C. T. insulin coma, clorpromazine or reserpine. Am. Arch. Gen. Psychiat. 2: 606, 1960.

ALTIRIBA, J. E. y col. Causas yatrógenas del sufrimiento fetal. En el libro Sufrimiento Fetal en el parto. Ed. Balmes. 197, 1967.

CORNER, B. D. Congenital malformations. Méd. J. Southwest. 77: 46, 1962.

COHEN, Y. Le passage transplacentaire des médicaments. Thérapie. 16: 509. 1961.

VAN CLEVELD, S. Coagulation disorders in the newborn period. Jr. of Pediat. 54: 633, 1959.

WARKANY, J. and FRASER, F. C. Prenatal factors in diseases of children. En Nelson, W. E. Textbook of pediatrics. 7 ed. W. B. Saunders Co. edit. Philadelphia, pág. 242, 1959.

MAUER, F. M.; DE VAUX and WAND LAHEY, M. E. Neonatal and maternal thrombocytopenic purpura due to quinine. Pediatrics. 19: 84, 1957.

The Médica! Letter. Vol. 9 N9 222, 1967.

SOLCISKI, A. y col. Malformación fetal y quinina. Instantanes Médicaux. 4: 297, 1966.

CHARLES, D. J. Obst. and Gynec. Britl. Emp. 61: 750, 1954.

CHASSAGNE P,. et GEORGES-JANET, L. Influence sur le fétus de certains traitements appliqués á la femme enceinte. Ann. Pediat. 37: 365, 1961.

SANCHEZ-CARVAJAL, A. M. Efectos adversos de las drogas y otros agentes sobre el feto. Rev. Obst. Gin. Venezuela. 28: 197, 1968.

KLINC, A. H.; BLATTNER, R. J. and LUNIN, M. Efecto transplacentario de las te-traciclínas sobre los dientes. J.A.M.A. 188: 178, 1964.

COHLAN, S. Q.; BEVELANDER, G. and TIAMSIG, T. Growth inhibition of prematures receiving tetracycline. Am. J. Dis. Child. 105: 453, 1963.

WALLMAN, I. S. and HILTON, H. B. Teeth pigmented by tetracycline. Lancet. 1 : 827, 1962.

SURHERLAND, J. M. and KELLER, W. H. Novobiocin and neonatal hyperbilirrubinemia investigation of relationship in epidemic of neonatal hyperbilirrubinemia. Am. J. Dis. of Child. 101: 447, 1961.

SILVERMAN, W. A.; ANDERSON, D. H.; BLANC, W. A. and CROZIER, D. N. Difference in mortality rates and incidence of ker-nicterus among premature infants allotted to 2 prophylactic antibacterial programs. Pediat. 18: 614, 1956.

TUCKMANN-DUPLES1ES, H. and MERCIER-PAROTL. The teratogenic action of the antibiotic actinomycin din congenital. Ed. G. E. W. Wolsten Holme and C. M. O'Connor, Boston, Little Brown, pág. 115, 1960.

VAN CREVELD, S. Coagulation disorders in the newborn period. Jr. of Pediat. 54:633, 1959.

SUGAR, S. J. Use of the sulfonylureas in diabetes mellitus. Ann. New York Acad.

Sc. 71 : 256, 1957.

LARSONY and STERKY, C. Possible teratogenic effect of tolbutamide in a pregnant prediabetic. The Lancet. 2: 1424, 1960.

GHANEM, M. H. The management of pregnant diabetes with sylponyl-urea compounds. Alexandria M. J. 6: 14, 1960.

The Médical Letter. Nº 238, 1968.

WICKES, I. G. Foetal defects following insulin coma therapy in early pregnancy. Brit. J. 2: 1029, 1954.

LAPLANE, R. y GEORGES-JANET. El riesgo fetal en los tratamientos endocrinos. La Presse Médical. 76: 785, 1968.

MELLIN, G. W. y KATZENSTEIN, M. Meclizine and fetal abnormalities. Lancet. 1 : 222, 1963.

YERUSHALMY, J. and MILKOVICH, L. Evaluation of the teratogenic effect of meclizine in man. Amer. J. Obstet. Gynec. 93: 553, 1965.

DUARTE-CONTRERAS, A. y ZUÑIGA, R. Progestógenos. Rev. Col. Obst. Gin. 14: 569, 1963.

APGAR, V. Problema de los fármacos en la gestación. Clin. Obstet. y Ginec. 623, 1966.

SMITH, R. Control de la respiración. En Anestesia para niños. Ed. Morvi Com. New York 48, 1959.

DUCHARME, J. R. Endocrine problems of the newborn infant. Ped. Clinics. N. A. 8: 565, 1961.

WILKINS, L. Masculinization of female fetus due to use of orally given progestins. J.A.M.A. 172: 1028, 1960.

WILKINS, L. Masculinization of the female foetus associated with the administration of oral and intramuscular progestins during gestation: non adrenal pseudohermafrodi-tism. J. Clin. Endocr. 18: 559, 1958.

LANGMAN, J. Medical Embriology. Williams and Wilkins, Baltimore, 1963.

BONGIOVANNI, A. M.; Dl GEORGE, A. M. and GRUMBACH, M. M. Masculinization of the famale infant associated with estrogenic therapy alone during gestation: four cases. J. Clin. Endocrinol and Metab. 19: 1004, 1959.

GRUMBACH, M. M. and col. J. Clin. Endo-crin. 19: 1369, 1959.

Aspectos clínicos del empleo de gestágenos orales. Resumen del informe N? 326 de la OMS. Rev. Col. Obst. Gin. 18: 353, 1968.

BONGIOVANNI, A. M. and McPODDEN, A. J. Steroids during pregnancy and possible fetal consequences. Fertility and Sterility. 11: 181, 1960.

HARRIS, J. W. S. and ROSS, I. P. Cor-tisone therapy in early pregnancy. Lancet. 1: 1045, 1956.

DOIG, R. K. and COLTMAN, O. M. Cleft palate following cortisone therapy in early pregnancy. Lancet 2: 730, 1956.

LEYSSAC, P. P. Suprarrenal steroids and pregnancy. Ugeskrift Laeger. 121 : 33, 1959.

HCTTINGER, A. Insuffisance cortico-surréna-lienne chez le nouveau-né de mére traité par la cortisone. Ann. Pediat. 37: 2469, 1961.

RAY, E. W.; STERLING, K. and GARDNER, L. I. Congenital cretinism associated with 1131 therapy of the mother, (abstract). A.M.A. Jr. Dis. Child. 90: 506, 1959.

BONGIOVANNY, A. M.; EBERLEIN, W. R. ; THOMAS, P. Z. and ANDERSON, W. B. Sporaid goiter of the newborn. J. Clin. Endocrinol and Metab. 16: 146, 1956.

RODRIGUEZ DE LA FUENTE, F.; CARDENAS-VARELA, S.; AREVALO-RODRIGUEZ, J.; MORA-AREVALO, S. y NASSAR-CONTRERAS,

M. Consideraciones hemodinámicas en el manejo analgésico y anestésico de la embarazada en trabajo de parto con diagnóstico de toxemia. Gin. Obstet. Méx. 153: 1, 1969.

FISHER, W. D.; WOORHESS, AA. L. and GARDNER, L. I. Congenital Hypothiroidism in infant following maternal I 131 Therapy (Clinical pathological conference). Jr. Pe-diatr. 62: 132, 1963.

ADAMS, A. E. The effect of antithiroid drug. Anat. Rec. 104: 421, 1949.

JULIEN-MARIE, A.; HENNEQUET, A.; LYON, C.; DEBRIS, P. et LE BELLE, J. C. Dépendence á la pyridoxine: une maladie métaboüque. Rev. Neurol. 105: 406, 1961.

Comunicación personal de Laboratorios Glaxo, el 10 de septiembre de 1969.

LUCEY, J. F. and DOLAN, R. G. Hyperbili-rrubinemia of new horn infants associated with the parenteral administration of a vitamin K analogue to the mothers. Pediatrics 23: 553, 1959.

GORDON, R. R. and DEAN, T. Fetal deaths from antenatal anticoagulant therapy. Brit. M. J. 2: 719, 1955.

JOSEPH, R. Fetal haemorrhages induced by the administration of anticoagulants to the pregnant woman. Sem. Ther. 38:115,1962.

SOKAL, J. E. and LESSMAN, E. M. Effect of cancer chemotherapeutic agents on the human fetus. J.A.M.A. 172: 1765, 1960.

MELTZER. H. J. Congenital anomalies due to attempted abortion with 4-aminopteroglutamic acid. J. Amer. Med. Ass. 161 : 1253, 1956.

SMITH, R. B. W., SHEEHY, T. W. and ROTHBERG, H. Hodgkings disease and pregnancy. Arch. Inst. Med. 102: 777, 1958.

SBOTTON, D. and MONIE, I. W.: Possible teratogenic effect of chlorambucil of a human foetus. J.A.M.A. 186: 174, 1963.

THIERSCH, J. B.: Therapeutic abortion with a folic acid antagonist administered by the oral route. Am. J. Obstet, Gynec. 63: 1298, 1952.

REVOL, L, VIALA, J., PELET, J. and CROI-ZAT, P. Hodgkin's disease, linphosarcoma, reticulosarcoma and pregnancy. New Rev. Franc. Hémat. 2: 31 1, 1962.

STUTZMAN, L. y SOKAL, J. E. Uso de anticancerosos durante la gestación. Clínicas Obstét. y Ginecol. 416, 1968.

GREENBERG, H. L. and TANAK, K. R. Congenital anomalies probably induced by ciclophosphamide. J. Amer. Med. Ass. 188: 423, 1964.

LUTWAK-MANN, C. and HAY, M. F. Effect on the early embryc of agents administered to the mother. Brit. Med. J. 2: 944, 1962.

KARNOFSKY, D. A. Late effects of inmunesupressive anticancer drugs. Fed. Proc. 26: 925, 1967.

GREENBERG, M. and col. Effect of Smalpox vaccination during pregnancy on incidence of congenital malformation. Pediatrics. 3: 456, 1949.

McARTHUR, P. Congenital vaccinic and vaccinic gravidarum. Lancet. 2: 1104, 1952. BURNETT, S. G. Monphinism in pregnancy and the newborn. The Med. Herald 27: 161, 1920.

HAGERMANN, D. D. and VILEE, G. A. Transport functions of the placenta. Phys. Reviews 40: 313, I960.

USUBIAGA, J. E. Mesa Redonda sobre Analgesia y Anestesia obstétrica en el IX Congreso Colombiano de Anestesiología. Medellin, agosto 13-16, 1969.

EARLE, R. Congenital salicylate intoxication. Report of a case. New Eng. J. Med. 265 : 1003, 1961.

SNYDER, F. F. Obstetric analgesia and anesthesia. W. B. Saunders Comp. Philadelphia, 1949.

COSMI, E. and MORISHIMA, H, O. Actas Symposium. "Problems of foetal distress. Siene (Italia), sept. 1966.

BOTELLA-LLUSIA, J. y col. Acta Gin. 12: 661, 1961.

DEXEUS, J. M. y GONZALEZ-RUIZ, J. Progres. Obstet. Gin. 6: 11, 1963.

DESMONIL, M. M. Phisical signs accomp-ning transition. In Phisical Diagnosis of the newborn. Aorty sixth Ross Conference on Pediatric research, Columbus, Ohio, Ross Laboratories, 18, 1964.

YOUNG, I. M. Placental transfer of hexa-metonium bromide in rabit and its appe-rance in amniotic fluid. J. Physiol. 166: 4, 1956.

HALLUM, J. and HATCHUEL, W. Congenital paralytic ileus in a premature baby as a complication of hexamethonium bromide therapy for toxemia of pregnancy. Arch. Dis. Child. 29: 354, 1954.

KING, C. T. G. Teratogenic effects of meclizine hydrochlorhide on the rat. Science 14: 353, 1963.

LENZ, W. Malformations caused by drugs in pregnancy. Amer. J. Dis. Child. 112: 99, 1966.

BROWN, A. K. and CEVIK, N. Hemolysis and jaundice in the newborn folowing maternal treatment with sulphamethoxypiridazine. Pediatrics. 36: 742, 1965.

SANCHEZ CONTRERAS, J., KASSEM CAMACHO, J. y MARADIEGUE MENDEZ, E. La toxoplasmosis como factor de infertilidad. Gi-nec. Obste. Méx. 151 : 539, 1969.

SANCHEZ CONTRERAS, J. y RUIZ VELASCO. Algunos factores etíológicos del aborto habitual. Obste. Ginec. Méx. 21 : 677. 1966.

SPNIGAR, L. I. y EDELMAN, M. H. Parasitosis y embarazo. En Complicaciones médicas, quirúrgicas y ginecológicas en el embarazo. De Rovinsky, J. J. Ed. Intera-mericana S. A. 2a. Ed. México. 603, 1964.

BOCQUET, L. Les dangers des anticoagulants au cours de la grossesse. Thérapie. 69: 507, 1961.

WEISS, C. F., GLAZKO, A. J. and WESTON, J. K. Chloranphenicol in the newborn infant. New England J. Med. 262: 787, 1960.

MEYER, R. Teratogenic effects of sulfony-lura derivatives 2-deoxy glucosa and sodium fluro-acetate in rats. Fourth Congress of the International Diabetes Federation, Geneva, Switzerland, july 10-14. 401, 1961.

GARCIA, R. E., FIEDMAN, W. F., KABA-CHA, M. M. and ROWE, R. A. Idiopatic hypercalcemia and supravalvular aortic stenosis. Documentation of a new Syndrome. New England J. Méd. 271: 117, 1964.

RODRIGUEZ, S. U., LEIKIN, S. L. and HILLER, M. C. Neonatal thrombocytopenia associated with ante-partum administration of thiazide drugs. New England J. Med. 270: 881, 1964.

GRAY, M. J. Uso y abuso de las tiazidas en la qestación. Clínicas Obstét. y Ginecol. 568, 1968.

LAYTON, W. M. and HALLESY, D. W. Deformity of forlimb in rats: association with high doses of acetazolamide. Science 149: 306, 1965.

ESBANSHADE, J. H. Jr. and SMITH, R. J. Thiazides and pregnancy: a study of carbohydrate tolerance. Amer. J. Obstet. Gynec. 92: 270, 1965.

GOODLIN, R. C. and KAISER, I. The effect of amonium chloride induced maternal acidosis on the human fetus at term. Ann. J. M. J. C. 233: 662, 1957, and 235: 555, 1958.

MINKOWITZ, S., SOLOWAY, H. B., HALL, J. E. and YERMAKOV, V. Fatal hemorrhagic pancreatitis following chlorotiazide administration in pregnancy. Obstet. and Gynec. 24: 337, 1964.

KRAUS, C. W., MARCHESE, J. R. and YEN, S. S. C. Prophylactic use of hydrochlpro thiazide in pregnancy. J.A.M.A. 198: 1150, 1966.

SCHNIDER, S. M. Foetal and neonatal effects of drugs in obstetrics. Anesth. Analg. 45: 372, 1966.

APGAR, V. Perinatal sequelae of drugs and anesthetic agents. Harper Hostp. Bull. 24: 135, 1966.

GARNET, J. D. Placental transfer of chlorothiazide. Obstet. and Gynec. 21: 123, 1963.

BATTAGLIA, F., PRYSTOWSKY, H„ SMIS-SON, C, HELLEGERS, A. and BRUNS, P. Fetal blood studies. XIII. The effect of the administration of fluids intravenously to mothers upon the concentrations of water and electrolytes in plasma of human fetuses. Pediatrics. 25: 2, 1960.

SCHIFRIN, B. S., SPELLACY, W. N. and LITTLE, W. A. Maternal death associated with excesive ingestion of a chlorothiazide diuretic. Obstet. and Gynec. 34: 215, 1969.

BOLLETTI, M. e CROATTO, L. Sulla surdi-tá da passagio transplacentare di streptomicina. Acta Pediat. Lat. Reggio. 11: 1, 1958.

SWALLOW, J. N. Discoluoration of primary dentition after maternal tetracycline ingestion during pregnancy. Lancet. 2: 611, 1964.

RENDLE-SHORT, T. J. Tetracycline in teeth and bones. Lancet 1: 1 188, 1962.


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