Efectos de la heroína, marihuana, LSD y metadona sobre la reproducción


  • G. Pardo lnstituto Iberoamericano de Cooperación
  • J. Remohi Facultad de Medicina de Valencia
  • A. Pellicer Facultad de Medicina de Valencia
  • F. Bonilla-Musoles Facultad de Medicina de Valencia




El uso de los estupefacientes es tan viejo como la propia humanidad .Una descripción del cultivo y preparación del opio no muy diferentes de los métodos modernos han sido hallados en las tablillas asirias que datan del 7000 antes de C. (64). 

Referencias bibliográficas

ACKER D; SACHS BP; TRACEY K; WISE E (1983): Abruptio placentaeassociated with cocaine use. A.J. Obstet. Gynecol 146: 220-221.

ALARCON, C. (1978). Aspectos farmacológicos de las sustancias capaces de producir dependencia y adicción. JANO 309: 21-34.

ALHUJAJ, M. y SCHONTHAL, H. (1972). H.A.A. in drug addicts. Lancet 1: 205-205.

ALLOZA J.L.; Síndrome de abstinencia, por narcóticos en recién nacidos. JANG, 561,44-45, 1983.

AMOROSE A.P., y NORUSIS M.J.: Cytogenetics of methadone-managed and heroin-additecd pregnant women and their newborn infants. Am. J. Obstet. Gynecol. 124,635-640, 1976.

ANNUNZIATO D. Neonatal addiction to methadone. Pediatric 47, 787-790, 1971.

ASCH RH, SMITH CG: Effects of Marihuana on reproduction. Contemporary Obs/Gyn. 1983, 22, 217-225.

AUERBACH; y RUGOWSKI J.A.: Lysergic acid diethylamide: effect on embryos. Science 157: 1325-1326, 1967.

BAI, J.: GREENWALD, E.: CATER IN I, H. y KAMINETZKY, H. (1974). Drug Related Menstrual Aberration. Obstet. Gynecol. 44: 713-719.

BERLIN C.M., JACOBSON C.B.: Psychodelic drugs a threat to reproduction? Pediatric Res. 4: 377, 1970.

BLINICK G, WALLACH R., y JEREZ E.: Pregnancy in narcotic addicts treated by medical withdrawal. Am. J. Obstet. Gynec. 105, 997-1003, 1969.

BLINICK G.: Fertility of narcotic addicts and effects of addiction on the offspring. Social Biol. 18, 345-351, 1971.

BLINICK, G.; TAVOLGA, W. y ANTOPOL, W. (1971). Variations in birth cries of newborn infants from narcotic-addicted and normal mothers. Am. J. Obstet. Gynecol. 110: 948-956.

BLINICK G: INTURRISI C.E.; JEREZ E.; WALLACH R. Methadone assays in pregnant women and progeny. Am. J. Obstet. Gynecol. 121.617-621, 1975.

BLINICK, G.; WALLACH, R.; JEREZ E. y ACKERMAN, B.D. (1976). Drug addiction in pregnancy and the neonate. Am. J. Obstet. Gynecol. 125: 135-142.

BOLTON P.F: Drugs of abuse. En Hawkins D: Drugs and Pregnancy. Pag. 128-154. Edit: Churchill Livingstone; Londres.

CLAMAN, A. y STRANG, R. (1962). Obstetric and ginecologic aspects of heroin addiction. Am. J. Obstet. Gynecol. 183: 252-257.

COBRINIK, R.W.; HOOD, R.T. y CHUSID, E. (1959). The effect of maternal narcotic addiction in newborn infant. Review of the literature and report of 22 cases. Pediatrics 24: 288-292.

COHEN M.M., MARINELLO M.J. y BACK N.: Chromosomal damage in human leukocytes induced by lisergic acid diethylamide. Science 155: 1417-1419, 1967.

COHEN M.M., HIRSCHHORN K., y FROSCHWA: In vivo and in vitro chromosomal damage induced by LDS— 25. New Eng. J. Med. 277: 1043-1099. 1967.

COHEN M.M., y MUKHERJEE AB.: Meiotic chromosome damage induce by LSD-25. Nature 219: 1072-1074. 1968.

CONNAUGHTON, J.F.; REESER, D.; SCHUT, J. y FINNEGAN, L. (1977). Perinatal addiction: outcome and management. Am. J. Obstet. Gynecol. 129: 679-686.

DESMOND, M.; FRANKLIN, R.; BLAT-TNER, R. y HILL, R. (1961). The relation of maternal disease to fetal and neonatal morbility and mortality. Pediatric clinics North Amer. 8: 421 -429.

DELTERIO S, FUAUD B, BARTKE A. MAYFIED D.: Cannabinoids in male mice: effects on fertility and spermatogenesis. Science 1982, 216, 315-316.

DIXIT VP, SHARMA VN, LOHIYA NK,: The effect of chronically administered cannabis extract on the testicular function of mice. Europ. Phamacol. 1974, 26, 111-114.

DUMAS K.W.: Parenteral drug usage: effect upon chromosomes of progeny. Pediatrics 47: 1037-1041. 1971.

ECHEVARRIA, J.; CALLEN, M.; ALUSTIZA' E.; ORUETA, Y.; TRABA, L. y PAISAN, L. (1983). Hallazgos neonatales en hijos de drogadictas. An. Esp. Pediatr. 19: 439-443.

EGOZCUE J., IRWIN S., MARUFFO CA: Chromosomal damage in LSD users. Jama 204: 214-218. 1968.

FABRE R, TRUAUT R.: Cañamo Indiano. Tratado de Toxicología Editorial Paraninfo, Madrid, 1977. Pgs. 157-161.

FINNEGAN L,P; CONNAUGHTON J, F; EMICH J, P. y WELAND W, F: Comprehensive drug problems. 1: 795, 1972.

FREIXA F.: Alucinógeno. En: Freixa F. y Soler Insa PA: Toxicomanías un enfoque multidisciplinario pág. 233-245 (Ed: Fontanela Barcelona. 1980).

GAULDEN, E.; LITTLEFIEL, D.; PU-TOFF, O. y SIEVERT, A. (1964). Menstrual abnormalities associated with heroin addiction. Am. J. Obstet. Gynecol. 90: 155-160.

GEBER W.F.: Congenital malformations induced by mescaline, lysergic acid diethylamide and bromolysergic acid in the hamster. Science 158: 265-266. 1967.

GISBERT, J.A. (1977). Intoxicaciones por sustancias psicoactivas. En Medicina Legal y Toxicología, Ed. Fundación García-Muñoz. Sección Saber. Valencia, pp. 152-161.

GLASS, L.; RAJEGOWDA, B.K. y EVANS, H.E. (1971). Absence of respiratory distress syndrome in premature infants of heroin addicted mothers. Lancet 2: 685-686.

GOODFRIEND, M.I.; SHEY, I. y KLEIN M. (1956). The effects of maternal narcotic addiction on the newborn. Am. J. Obstet. Gynecol. 71: 29-36.

HARRISON R, MANTILLA B.: Prenatal toxicity maternal distribution and placental transfer of Tetrahydrocannabinol. J. Pharmacol. 1972. 180, 446-453.

HECH F, BEALS RK, LEES MH, JOLLY H, ROBERTS P.: Lysergic-acid-diethila-mide and cannabis as possible teratogens in man. Lancet II. 1968, 1.087.

HEMBREE WC,: Long-term marihuana use: can it reduce fertility? Contemporary Obs/Gyn. 1984. 23, 67-72.

HILL, R.M.y DESMOND, MH. (1963). Management of narcotic withdrawal syndrome. Pediat. Clin. North. Amer. 10: 67-72.

HUGUET, E. (1980). Estat actual de l'acció de certes toxicomanies maternes sobre linfant gestat sota llurs influencies Annals de Medicina 62: 655-662.

IRWIN S, y EGOZCUE J: Chromosomal abnormalities in leucocytes from LSD-25 users. Science, 157, 313-314. 1967.

JACOBSON CB. y BERLIN CM: Possible reproductive detriment in LSD users. Jama: 222, 1367-1373, 1972.

JAFFE J,H; MARTIN W,R; ANALGESICOS y antagonistas opiáceos. En GOODMAN A; GOODMANL; GILMAN A: Las bases farmacológicas de la terapeútica. pág. 516-532. Ed.: Panamericana, Buenos Aires.

JAGIELLO G. y POLANI PE: Mouse germ cells and LSD-25. CYTOGENETICS 8: 136-147. 1969.

JARVIK LF. y KATO T: Is Lysergide a teratogen? Lancet i: 250 1968.

KAHN, E.; NEUMANN, M. y POZK, G. (1969). The course of the heroin withdrawal syndrome in newborn infants treated with phenobarbital or chlorpro-mazine. J. Pediatrics. 75: 495-501.

KARAKUSHANSKY G, NEW RF, GARDNER LJ.: Lysergide and cannabis as possible teratogens in man. Lancet II. 1969. 150-151.

KOLODNY R. C. MASTERS WH, KO-LODNER AB. Depresión of plasma testosterone levels after chronic intensive marihuana use N. England J Med. 1974 290: 872-876.

KUNSTANTER, R.H.; KLEIN, R.I.; LUNDEEN, E.C.; WITZ, W. y MORRISON, M. (1958). Narcotic withdrawal symptoms in newborn infants. JAMA 268: 1.008-1.010.

LAPORTE J.: Las drogas: aspectos farmacológicos y epidemiológicos. Perspectivas terapéuticas con su fundamento farmacológico. Vol. V. Sistema Nervioso Central. Fundación García Muñoz Valencia, 1981. Pgs. 492-496.

LEMBERGER L, SILVERSTEIN SD, AXELROD J. KOPIN IJ.: Marihuana studies on the disposition and metabolism of delta-9-tetrahidrocannabinol in man. Science 1970. 170,1.320-1.322.

LITT, I.F. y COHNE, M.l. (1970). The drug-using adolescent as pediatric patient. Pediatric. 77: 195-202.

LONG SY: Does LSD induce chromosomal damage and malformations? A review of the literature. Teratology 6: 75-90. 1972.

LOURIA, D.; HENSLE, T. y ROSE, I. (1967). The major complications of heroin addiction. Am. Intern. Med. 67: 1-10.

MAHENDER, A.; HARPER, R.G, y STERN, G. (1971). Observations on heroin and methadone withdrawal in the newborn. Pediatrics. 48: 353-358.

MANN L, I; BHAKTHAVATHSALAN A; LIU M. MAKOWSKI P: The effect of methadone on fetal brain function. Am. J. Obstet. Gynecol 124: 699-704, 1976.

MARTIN PA.: Cannabis and chromosomes. Lancet I, 1969. Pág. 370.

MAURER, D.W. y VOGEL, V.H. (1954). Narcotics y narcotic addiction. Spring-field, III. Charles C. Thomas, Publisher.

McGLOTHLIN WH, SPARKES RS. y ARNOLD DO: Effect of LSD on human pregnancy. Jama 212: 1483-1487. 1970.

MENDELSON JG, KUEHLE J, ELLIG-BOE J. Plasma testosterone level before, during and after chronic marihuana smoking. N. England. J. Medicin. 291, 1051-1054. 1974.

MERIGGI E. y MANSUETO A: Tossico-dipendenza in campo ostetrico e ginecológico. MINERVA GINECOL 32: 143-156. 1980.

MIDWIDSKY A, JOUNES MA, BESCH NF, et al: The effect of tetrahidrocanna-binol on the cytosol and microsomal fractions of the term human placenta. Pharmacologist 1979, 21: 320.

MILKOVICH, L. y VAN DEN BERG, B.J. (1977). Effects of antenatal exposure to narcotics drugs. Am. J. Obstet. Gynecol. 129: 637-642.

MIRKIN BL; Drug distribution in pregnancy. En HAWKINS DF: Drugs and pregnancy, pág. 1-26 (Ed): CHURCHILL LIVINGSTONE. Londres. 1983.

NAEYE, R.L.; BLANC, W.; LEBLANC, W. y KHATAMEE, M.A. (1973). Fetal complications of maternal heroin addiction: Abnormal growth, infections, and episodes of stress. J. Pediatr. 83: 1.055-1.061.

NAHAS G, Marihuana-deceptive weed; Raven Press. New York. 1973.

NAHAS G, Aspectos biomédicos del consumo del cannabis. Avances en terapéutica, 10, 183-199, 1980.

NEUBERG, R. (1970). Drug addiction in pregnancy: A review of the problems and their management. J. Obstet. Gynec. Brit. Comm. 77: 1.117-1.122.

NEWMAN R.G; BASHKON S; y CALKO D: Results of 313 consecutive live births of infants delivered to patients in the New York City. -Methadone maintenance treatment program. Am. J. Obstet. Gynecol. 15: 233-237: 1975.

OSTREA, E.M.; CHAVEZ, C.J. y STRAUSS, M.E. (1976). A study of factors that influence severity of neonatal narcotic withdrawal. J. Pediatr. 88: 642-645.

OSTREA, E.M. y CHAVEZ, C.J. (1979). Perinatal problems (excluinding neonatal withdrawal) in maternal drug addiction. A study of 830 cases. J. Pediatr. 94: 292-295.

PELOSI, M.A.; FRATTAROLA, M.; APUZZIO, J.; LANGER, A.; HUNG, C.T.; OLESKE, J.M.; BAI, J. y HARRI-GAN, J.T. (1975). Pregnancy complicated by heroin addiction. Obstet. Gynecol. 45: 512-515.

PERLMUTTER, J.F. (1967). Drug addiction in pregnant women. Am. J. Obstet. Gynecol. 99: 569-572.

PERLMUTTER, J.F. (1974). Heroin addiction and pregnancy. Obstet. Gynecol. Surv. 29: 439-446.

PERSAUD I, ELLINGTON A.: Cannabis in early pregnancy. Lancet. II. 1.036. 1967.

PERSAUD I, ELLINGTON A, Teratogenic activity of cannabis resin. Lancet II. 1968, 406-407.

PRITCHARD J.A., MASON R., CORLEY M„ and PRITCHARD S.: Genesis of severe placental abruptio. Am. J. Obstet Gynecol. 108: 22, 1970.

RAJEGOWA, B.K.; GLASS, L; EVANS, H.E.; SWARTZ, D.P. y LEBLANC. W. (1972). Methadone withdrawal in newborn infants. J. Pediatr. 81: 532-534.

RAMIREZ RUIZ, Editorial ABC Madrid. Domingo 11-XI-1984.

REDDY A, M; HARPER RG y STERN G: Observations on heroin and methadone withdrawal in the newborn. Pediatric 48: 353-358, 1971.

REMENTERIA, J.L. (1977). Drug abuse in pregnancy and neonatal effect. The C.V. Mosby company St. Louis.

REMOHI J., PARDO G.; LEGUA V., BONILLA-MUSOLES F.: Revisión de conjunto: LSD. Metadona y Reproducción. Acta Ginecológica 42: 450-459. 1985.

RITCHIE JM; GREENE N. (1981): Anestésicos locales. En: GOODMAN A; GOODMAN L; GILMAN: Las bases farmacológicas de la terapéutica, pp. 306-320. Ed. Panamericana. Buenos Aires.

ROSEN, M. (1972). Use of diazepam in neonatal narcotic withdrawal syndrome. Pediatric. 49,314-317.

SCHNECK, H. (1958). Narcotic withdrawal symptoms in the newborn infant resulting from maternal addiction. J. Pediatric. 52: 584-587.

SCHWARTZ S, HARCLERODE J, NY-QUIST SE: Effects of delta-9-tetrahidro-cannabinol administration on marker proteins of rat testicular cells. Life Sci. 1978, 22. 7.

SHUTE, E. y DAVIS. M. (1933). Effect on infant of morphine administered in labor. Surg. Gynec. Obst. 57; 727-736.

SOLER, P.A. (1981). Opiáceos. En Toxicomanías. Un enfoque multidisciplinario. Ed. Fontanella. Barcelona, pp. 247-255.

SOLER, P.A. y SOLE, J.R. (1981). Clínica de los opiáceos. En Toxicomanías. Un enfoque multidisciplinario. Ed. Fontanella. Barcelona, pp. 339-352.

SOLER INSA PA: Problemática y aspectos del tratamiento de los heroinómanos. En FREIXA F y SOLER INSA PA: Toxicomanía un enfoque multidisciplinario: pág. 493-524. Barcelona.

SOLER, P.A. (1984). Síndrome de abstinencia de opiáceos: patogenia, clínica y tratamiento. Sandorama III; 5-11.

STATER, D.E. y WARDELL, J.N. (1972). Heroin addiction during pregnancy. Am. J. Obstet. Gynecol. 113: 273-280.

STEG, N. (1957). Narcotic withdrawal reactions on the newborn. A.M.A. Am. J. Dis. Child. 94: 286-288.

STEGER RW; SILVERMANN AY; JOHNS A; ASCH R. (1981): Interactions of cocaine and Tetrahydrocannabinol with the hypothalamic—hypophysial axis of the female rat. Fértil Steril 35: 567-572.

STEINBERGER E, DIXEM WJ,: Some observations on the effects of heat on the testicular germinal epithelium. Fértil Sterl. 10, 578-594,1959.

STERN, R. (1966). The pregnant addict. Am. J. Obstet. Gynecol. 94: 253-267.

STOFFER, S. (1968). A ginecologic study of drug addicts. Am. J. Obstet. Gynecol. 101: 779-786.

STOFFER, S.; TWEEDDALE, D.N. y SAPIRA, J.D. (1968). Secondary amenorrhea persisting after cessation of narcotic addiction. Obstet. Gynecol. 101: 779-783.

STONE, M.L.; SALERNO, L.J.; GREEN, M. y ZELSON, C. (1971). Narcotic addiction in pregnancy. Am. J. Obstet. Gynecol. 109 (s): 716-723.

STRAUSS, M.E.; ANDRESKO, M.; STRYKER, J.C.; WARDELL, J.N. y DUNKEL, L.D. (1974). Methadone maintenance during pregnancy: Pregnancy, birth, and neonate characteristics. Am. J. Obstet. Gynecol. 120: 895-900.

SUSSMAN, S. (1963). Narcotic and methamphetamine use during pregnancy: Effect on newborn infants. Am. J. Dis. Child. 106: 325-332.

SKAKKEBACK NE, PHILIP J. y RAFE LSEN OJ: LSD in mice: Abnormalities in meiotic chromosomes. SCIENCE 160: 1246-1248. 1968.

TITUS RJ; Lysergic acid diethyamide. Its effects on human chromosomes and human organism in útero a review of current findings. Intern Addict 7: 701-704. 1972.

TJIO JH: LSD and chromosomes. JAMA 210: 849-856. 1969.

TRICOMI, V. (1976). Annual obstetrical reports. Dept, of Obstetrics and Gynecology, Brooklyn. Cumberland Medical Center Brooklyn N.Y.

UGALDE, F.J.; APESTEGUI, A.; DE ARRIBA, A.; RIVERO, B.; GOROSTIA-GA, J. y LARRAZ, J.J. (1983). Problemas obstétricos de ia gestante drogadicta. Rev. Esp. Obst. y Gin. 42: 405-410.

VAN BLERK GA; MAJERUS TC; y MYERS RAM: Teratogenic potential of some psychopharmacologic drugs. A. brief review. Inter. J. Gynaecol. Obstet. 17: 399-402, 1980.

WALLACH RC; JEREZ E; y BLINICK G: Pregnancy and menstrual function in narcotics addicts treated with methadone. Am. J. Obstet. Gynecol. 105: 1.226-1.229, de 1969.

WARKANY J, TAKACS E: Lysergic acid diethilamide (LSD): No teratogenicity in rats. Science 159: 731-732. 1968. WOLFE BH. The Hippies. New American Library, New York. 1968. ZELLWEGER H, McDONALD JS, y ABBO G.-. Is Lysergic Acid Diethilamide a teratogen? Lancet 2, 1066 -1067.1967.

WERNER, A. (1969). Near-fatal hyperacute reaction to intravenously administered heroin. Jama 207: 2.277-2.278.

ZANOIO, L.; ZACCHE, G.; PEZZINI, M.B. y MARTINELLI, A. (1981). Consequenze ginecologiche ed ostetriche dell' uso di eroina. Minerva Ginecológica. 33: 257-262.

ZELZON, C.; RUBIO, E. y WASSER-MAN, E. (1971). Neonatal narcotic addiction: 10 year observation. Pediatrics 48: 178-183.

ZELLWEGER H, McDONALD JS, ABBO, J.: Cannabis as possible teratogens in man. Lancet II, 1967: 1.066.

ZUCKERMAN B, ALPERT JJ, DOO-LING E, et al: Substance abuse during pregnancy and newborn size. Pediatr. Res. 1980. 15:4.

ZUSPAN FP; GUMPEZ JA; MEJIA-ZELAYZ A; MADDEN J. y DAVIS R; Fetal stress from methadone withdrawal. Am. J. Obstet. Gyneco. 122: 43-46, 1975.

Cómo citar

Pardo G, Remohi J, Pellicer A, Bonilla-Musoles F. Efectos de la heroína, marihuana, LSD y metadona sobre la reproducción. Rev. Colomb. Obstet. Ginecol. [Internet]. 27 de junio de 1986 [citado 3 de octubre de 2022];37(3):165-82. Disponible en: https://revista.fecolsog.org/index.php/rcog/article/view/1901


Los datos de descargas todavía no están disponibles.






Artículos sin sección